Plasma p‐tau181, p‐tau217, and other blood‐based Alzheimer's disease biomarkers in a multi‐ethnic, community study
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Abstract
Introduction: Blood‐based Alzheimer's disease (AD) biomarkers provide opportunities for community studies and across ethnic groups. We investigated blood biomarker concentrations in the Washington Heights‐Inwood Columbia Aging Project (WHICAP), a multi‐ethnic community study of aging and dementia. Methods: We measured plasma amyloid beta (Aβ)40, Aβ42, total tau (t‐tau), phosphorylated tau (p‐tau)181, and p‐tau217, and neurofilament light chain (NfL) in 113 autopsied participants (29% with high AD neuropathological changes) and in 300 clinically evaluated individuals (42% with clinical AD). Receiver operating characteristics were used to evaluate each biomarker. We also investigated biomarkers as predictors of incident clinical AD. Results: P‐tau181, p‐tau217, and NfL concentrations were elevated in pathologically and clinically diagnosed AD. Decreased Aβ42/Aβ40 ratio and increased p‐tau217 and p‐tau181 were associated with subsequent AD diagnosis. Discussion: Blood‐based AD biomarker concentrations are associated with pathological and clinical diagnoses and can predict future development of clinical AD, providing evidence that they can be incorporated into multi‐ethnic, community‐based studies.
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Previous studies have provided evidence that p-tau217 has excellent performance in different racial and ethnic groups.
“While p-tau217 was not available in some cohorts, previous studies have provided evidence that this biomarker also has excellent performance in different racial and ethnic groups54,55.”
From Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability (2024) · cites this paper as [54]
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- Authors
- Brickman, A. M., Manly, J. J., Honig, L. S., Sanchez, D., Reyes‐Dumeyer, D., Lantigua, R. A., Lao, P. J., Stern, Y., Vonsattel, J. P., Teich, A. F., Airey, D. C., Proctor, N. K., Dage, J. L., & Mayeux, R.
- Affiliations
- NewYork–Presbyterian Hospital (US)
- Columbia University (US)
- Eli Lilly (United States) (US)
- Corresponding author
- Mayeux, Richard
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2021-02-13
- Volume
- 17
- Issue
- 8
- Pages
- 1353-1364
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC8451860
- OpenAlex
- W3126187484
- Cited by
- 387
- References
- 9
- Citations by year
- 2026: 59 · 2025: 98 · 2024: 81 · 2023: 69 · 2022: 58 · 2021: 21
- FWCI
- 41.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion, cc-by-nc-nd)
- medRxiv (acceptedVersion)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- IUScholarWorks (Indiana University) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute on Aging (RF1AG066107, R56AG034189, R01AG037212, P01AG007232, RF1AG054023, R01AG054520, R01AG034189, P01AG07232, P30AG066462, R01AG072474)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, blood-based biomarkers
- MeSH terms
- Aged, 80 and over, Alzheimer Disease, Autopsy, Ethnicity, Female, Humans, Male, New York City, Phosphorylation, Biomarkers, Amyloid beta-Peptides, tau Proteins, Neurofilament Proteins, Positron-Emission Tomography
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