The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Modulation of use‐dependent plasticity by d‐amphetamine
Abstract
Use‐dependent plasticity, thought to contribute to functional recovery after brain injury, is elicited by motor training. The purpose of this study was to determine if administration of d‐amphetamine facilitates the effects of motor training on use‐dependent plasticity. Healthy human volunteers underwent a training period of voluntary thumb movements under the effects of placebo or d‐amphetamine in different sessions in a randomized double‐blind, counterbalanced design. Previous work in a drug‐naive condition showed that such training causes changes in the direction of thumb movements evoked by transcranial magnetic stimulation and in transcranial magnetic stimulation‐evoked electromyographic responses. The endpoint measure of the study was the magnitude of training‐induced changes in transcranial magnetic stimulation‐evoked kinematic and electromyographic responses in the d‐amphetamine and in the placebo conditions. Motor training resulted in increased magnitude, faster development and longer lasting duration of use‐dependent plasticity under d‐amphetamine compared to the placebo session. These results document a facilitatory effect of d‐amphetamine on use‐dependent plasticity, a possible mechanism mediating the beneficial effect of this drug on functional recovery after cortical lesions.
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“Interestingly, this use-dependent plasticity rests on neuromodulatory transmitter function (Bütefisch et al. 2002) of the sort that may encode precision (Friston 2008).”
From Action and behavior: a free-energy formulation (2010) · cites this paper as Bütefisch et al. 2002
Citations
Cites
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Sorted by citations
Computerized training of working memory in children with ADHD – a randomized, controlled trial
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“Use-dependent plasticity can be facilitated or inhibited by externally induced excitability changes: Excitability-enhancing pharmacological agents like amphetamine improve it (Bütefisch et al., 2002), whereas excitability reductions induced by GABA agonists diminish it (Blin et al.”
BackgroundResultInfluentialAction and behavior: a free-energy formulation
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Self-citation
Metadata
- Authors
- Bütefisch, C. M., Davis, B. C., Sawaki, L., Waldvogel, D., Classen, J., Kopylev, L., & Cohen, L. G.
- Affiliations
- National Institutes of Health (US)
- University of Rostock (DE)
- Corresponding author
- Cohen, Leonardo G.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2001-12-03
- Volume
- 51
- Issue
- 1
- Pages
- 59-68
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2085716451
- Cited by
- 182
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 4 · 2012: 5
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- OAM-NIH
- Humboldt Foundation
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- use-dependent plasticity, d-amphetamine, motor training, functional recovery after brain injury, cortical lesions, transcranial magnetic stimulation, electromyographic response, kinematic response, thumb movement
- MeSH terms
- Adult, Central Nervous System Stimulants, Brain Injuries, Conditioning, Psychological, Dextroamphetamine, Double-Blind Method, Electric Stimulation, Female, Humans, Magnetics, Male, Movement, Neuronal Plasticity, Thumb, Evoked Potentials, Motor
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