The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Destruction of neurons by cytotoxic T cells: A new pathogenic mechanism in rasmussen's encephalitis
Abstract
Rasmussen's encephalitis is a progressive epileptic disorder characterized by unihemispheric lymphocytic infiltrates, microglial nodules, and neuronal loss leading to the destruction of the affected hemisphere. In this study, immunohistochemical evaluation of specimens from 11 patients revealed lymphocytic infiltrates that consisted mainly of CD3+CD8+ T cells. Of these cells, 7.0% lay in direct apposition to MHC class I+ neurons. Confocal laser microscopy revealed that these lymphocytes contained granzyme B in a polar orientation toward these perikarya. Single neurons underwent apoptosis. These findings indicate that a T‐cell–mediated cytotoxic reaction induces neuronal death in Rasmussen's encephalitis. This study directly shows, for what we believe is the first time, that a cytotoxic T‐cell mechanism contributes to loss of neurons in human brain disease.
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Cites
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Self-citationMultiple sclerosis: In situ evidence for antibody‐ and complement‐mediated demyelination
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Self-citationIn situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
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Cited by
The role of inflammation in epilepsy
Vezzani, A., French, J., Bartfai, T., & Baram, T. Z. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.178 · Cited by 1,876
Cortical demyelination and diffuse white matter injury in multiple sclerosis
Kutzelnigg, A., Lucchinetti, C. F., Stadelmann, C., Brück, W., Rauschka, H., Bergmann, M., Schmidbauer, M., Parisi, J. E., & Lassmann, H. (2005) · Brain · doi:10.1093/brain/awh641 · Cited by 1,836
Self-citationInflammation in Neurodegenerative Disease—A Double-Edged Sword
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The Immunopathology of Multiple Sclerosis: An Overview
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Self-citationImmunopathology of autoantibody-associated encephalitides: clues for pathogenesis
Bien, C. G., Vincent, A., Barnett, M. H., Becker, A. J., Blumcke, I., Graus, F., Jellinger, K. A., Reuss, D. E., Ribalta, T., Schlegel, J., et al. (2012) · Brain · doi:10.1093/brain/aws082 · Cited by 695
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Metadata
- Authors
- Bien, C. G., Bauer, J., Deckwerth, T. L., Wiendl, H., Deckert, M., Wiestler, O. D., Schramm, J., Elger, C. E., & Lassmann, H.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2002-02-28
- Volume
- 51
- Issue
- 3
- Pages
- 311-318
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2141120827
- Cited by
- 364
- References
- 29
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bien, C. G., Bauer, J., Deckwerth, T. L., Wiendl, H., Deckert, M., Wiestler, O. D., Schramm, J., Elger, C. E., & Lassmann, H. (2002). Destruction of neurons by cytotoxic T cells: A new pathogenic mechanism in rasmussen's encephalitis. Annals of Neurology. https://doi.org/10.1002/ana.10100
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