The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Induction of MHC Class I Genes in Neurons
Abstract
Whether neurons express major histocompatibility complex (MHC) class I genes has not been firmly established. The techniques of confocal laser microscopy, patch clamp electrophysiology, and reverse transcriptase-polymerase chain reaction were combined here to directly examine the inducibility of MHC class I genes in individual cultured rat hippocampal neurons. Transcription of MHC class I genes was very rare in neurons with spontaneous action potentials. In electrically silent neurons, transcription was noted, with expression of β 2 -microglobulin under tighter control than in class I heavy chain molecules. Surface expression of class I molecules occurred only in electrically silent neurons treated with interferon γ. Immunosurveillance by cytotoxic T cells may be focused on functionally impaired neurons.
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Rat hippocampal neurons in dispersed cell culture.
Banker, G. A., & Cowan, W. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90594-7 · Cited by 1,110
Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H., & Lindholm, D. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07564.x · Cited by 897
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Gultekin, S. H. (2000) · Brain · doi:10.1093/brain/123.7.1481 · Cited by 1,123
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
Feng, J., Zhou, Y., Campbell, S. L., Le, T., Li, E., Sweatt, J. D., Silva, A. J., & Fan, G. (2010) · Nature Neuroscience · doi:10.1038/nn.2514 · Cited by 1,019
NF-kB: a crucial transcription factor for glial and neuronal cell function
O'Neill, L. A. J., & Kaltschmidt, C. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01035-1 · Cited by 1,013
Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity
Xanthos, D. N., & Sandkühler, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3617 · Cited by 580
New concepts in the immunopathogenesis of multiple sclerosis
Hemmer, B., Archelos, J. J., & Hartung, H.-P. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn784 · Cited by 580
Metadata
- Authors
- Neumann, H., Cavalié, A., Jenne, D. E., & Wekerle, H.
- Venue
- Science
- Published
- 1995-07-28
- Volume
- 269
- Issue
- 5223
- Pages
- 549-552
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010003461
- Cited by
- 449
- References
- 4
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Neumann, H., Cavalié, A., Jenne, D. E., & Wekerle, H. (1995). Induction of MHC Class I Genes in Neurons. Science. https://doi.org/10.1126/science.7624779
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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