Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke

Running enhances neurogenesis, learning, and long-term potentiation in mice

van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904

NITRIC OXIDE: A Physiologic Messenger Molecule

Bredt, D. S., & Snyder, S. H. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.001135 · Cited by 2,315

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

Gerber, H. P., McMurtrey, A. E., Kowalski, J., Yan, M., Keyt, B. A., Dixit, V. M., & Ferrara, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30336 · Cited by 2,007

Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats

Chen, J., Li, Y., Wang, L., Zhang, Z., Lu, D., Lü, M., & Chopp, M. (2001) · Stroke · doi:10.1161/01.str.32.4.1005 · Cited by 1,770

Structural mechanism for statin inhibition of HMG-CoA reductase

Istvan, E. S., & Deisenhofer, J. (2001) · Science · doi:10.1126/science.1059344 · Cited by 1,644

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

Kureishi, Y., Luo, Z., Shiojima, I., Bialik, A., Fulton, D. J., Lefer, D. J., Sessa, W. C., & Walsh, K. X. (2000) · Nature Medicine · doi:10.1038/79510 · Cited by 1,438

Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.

Gage, F. H., Coates, P. W., Palmer, T. D., Kuhn, H. G., Fisher, L. J., Suhonen, J., Peterson, D. A., Suhr, S. T., & Ray, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11879 · Cited by 1,024

Human marrow stromal cell therapy for stroke in rat

Li, Y., Chen, J., Chen, X. G., Wang, L., Gautam, S. C., Xu, Y. X., Katakowski, M., Zhang, L. J., Lü, M., Janakiraman, N., et al. (2002) · Neurology · doi:10.1212/wnl.59.4.514 · Cited by 867

Statins Have Biphasic Effects on Angiogenesis

Weis, M., Heeschen, C., Glassford, A. J., & Cooke, J. P. (2002) · Circulation · doi:10.1161/hc0602.103393 · Cited by 677

Vascular Endothelial Growth Factor Signals Endothelial Cell Production of Nitric Oxide and Prostacyclin through Flk-1/KDR Activation of c-Src

He, H., Venema, V. J., Gu, X., Venema, R. C., Marrero, M. B., & Caldwell, R. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.25130 · Cited by 490

Evidence for stroke-induced neurogenesis in the human brain

Jin, K., Wang, X., Xie, L., Mao, X. O., Zhu, W. P., Wang, Y., Shen, J., Mao, Y. Q., Banwait, S., & Greenberg, D. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603512103 · Cited by 644

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

Zhang, Z. G., & Chopp, M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70061-4 · Cited by 596

Atorvastatin Induction of VEGF and BDNF Promotes Brain Plasticity after Stroke in Mice

Chen, J., Zhang, C., Jiang, H., Li, Y., Zhang, L., Robin, A. M., Katakowski, M., Lü, M., & Chopp, M. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600034 · Cited by 451

Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APP Sw,Ind ) mice

Jin, K., Galván, V., Xie, L., Mao, X. O., Gorostiza, O. F., Bredesen, D. E., & Greenberg, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403678101 · Cited by 444

Effects of Acute Treatment With Pravastatin on Cerebral Vasospasm, Autoregulation, and Delayed Ischemic Deficits After Aneurysmal Subarachnoid Hemorrhage

Tseng, M.-Y., Czosnyka, M., Richards, H. K., Pickard, J. D., & Kirkpatrick, P. J. (2005) · Stroke · doi:10.1161/01.str.0000176743.67564.5d · Cited by 412

Angiogenesis after cerebral ischemia

Beck, H., & Plate, K. H. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0483-6 · Cited by 383

Mechanisms of neural plasticity following brain injury

Wieloch, T. W., & Nikolich, K. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.05.011 · Cited by 352

Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials

Kim, J. H., Jenrow, K. A., & Brown, S. L. (2014) · Radiation Oncology Journal · doi:10.3857/roj.2014.32.3.103 · Cited by 361

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

Hermann, D. M., & Chopp, M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70039-x · Cited by 333

Cholesterol in Alzheimer's disease

Shobab, L. A., Hsiung, G. R., & Feldman, H. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70248-9 · Cited by 350

Simvastatin-Mediated Upregulation of VEGF and BDNF, Activation of the PI3K/Akt Pathway, and Increase of Neurogenesis Are Associated with Therapeutic Improvement after Traumatic Brain Injury

Wu, H., Lu, D., Jiang, H., Xiong, Y., Qu, C., Li, B., Mahmood, A., Zhou, D., & Chopp, M. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2007.0369 · Cited by 304

Angiogenesis, neurogenesis and brain recovery of function following injury.

Xiong, Y., Mahmood, A., & Chopp, M. (2010) · PubMed · Cited by 297

Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice

Chen, J., Zacharek, A., Zhang, C., Jiang, H., Li, Y., Roberts, C., Lu, M., Kapke, A., & Chopp, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5071-04.2005 · Cited by 287

Defective Adult Neurogenesis in CB1 Cannabinoid Receptor Knockout Mice

Jin, K., Xie, L., Kim, S. H., Parmentier‐Batteur, S., Sun, Y., Mao, X. O., Childs, J., & Greenberg, D. A. (2004) · Molecular Pharmacology · doi:10.1124/mol.66.2.204 · Cited by 271

Statins: Mechanisms of neuroprotection

van der Most, P. J., Dolga, A. M., Nijholt, I. M., Luiten, P. G. M., & Eisel, U. L. M. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.02.002 · Cited by 268

Role of nitric oxide after brain ischaemia

Moro, M. Á., Cardenas, A. J., Hurtado, O., Leza, J. C., & Lizasoaín, I. (2004) · Cell Calcium · doi:10.1016/j.ceca.2004.02.011 · Cited by 265

Statins Increase Neurogenesis in the Dentate Gyrus, Reduce Delayed Neuronal Death in the Hippocampal CA3 Region, and Improve Spatial Learning in Rat after Traumatic Brain Injury

Lu, D., Qu, C., Goussev, A. V., Jiang, H., Lu, C., Schallert, T. J., Mahmood, A., Chen, J., Li, Y., & Chopp, M. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2007.0288 · Cited by 264

Simvastatin in aneurysmal subarachnoid haemorrhage (STASH): a multicentre randomised phase 3 trial

Kirkpatrick, P. J., Turner, C. L., Smith, C., Hutchinson, P. J., & Murray, G. D. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70084-5 · Cited by 253

Neurogenesis following Stroke Affecting the Adult BrainPreprint

Lindvall, O., & Kokaia, Z. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019034 · Cited by 242

Anti-inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury

Xu, X. J., Gao, W., Cheng, S., Yin, D., Li, F., Wu, Y., Sun, D., Zhou, S., Wang, D., Zhang, Y., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0934-2 · Cited by 238

Statin Therapy and Outcome After Ischemic Stroke

Chróinín, D. N., Asplund, K., Åsberg, S., Callaly, E. L., Cuadrado‐Godia, E., Díez‐Tejedor, E., Napoli, M. D., Engelter, S. T., Furie, K. L., Giannopoulos, S., et al. (2013) · Stroke · doi:10.1161/strokeaha.112.668277 · Cited by 235

Emerging treatments for traumatic brain injury

Xiong, Y., Mahmood, A., & Chopp, M. (2009) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210902769601 · Cited by 231

Exosomes in stroke pathogenesis and therapy

Zhang, Z. G., & Chopp, M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81133 · Cited by 228

Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics.

Candelario‐Jalil, E. (2009) · PubMed · Cited by 219

Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke

Chopp, M., Zhang, Z. G., & Jiang, Q. (2007) · Stroke · doi:10.1161/01.str.0000250235.80253.e9 · Cited by 203

Chronic Administration of Statins Alters Multiple Gene Expression Patterns in Mouse Cerebral Cortex

Johnson‐Anuna, L. N., Eckert, G. P., Keller, J. H., Igbavboa, U., Franke, C., Fechner, T., Schubert‐Zsilavecz, M., Karas, M., Müller, W. E., & Wood, W. G. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.075028 · Cited by 199

Statins and Stroke

Endres, M. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600116 · Cited by 205

Atorvastatin Reduces Neurological Deficit and Increases Synaptogenesis, Angiogenesis, and Neuronal Survival in Rats Subjected to Traumatic Brain Injury

Lu, D., Goussev, A. V., Chen, J., Pannu, P., Li, Y., Mahmood, A., & Chopp, M. (2004) · Journal of Neurotrauma · doi:10.1089/089771504772695913 · Cited by 198

Proliferation in the human ipsilateral subventricular zone after ischemic stroke

Martí‐Fábregas, J., Romaguera-Ros, M., Gómez‐Pinedo, U., Martínez‐Ramírez, S., Jiménez‐Xarrié, E., Marín, R., Martí‐Fábregas, J., & García‐Verdugo, J. M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181cbccec · Cited by 201

Favorable Outcome of Ischemic Stroke in Patients Pretreated with Statins

Martí-Fàbregas, J., Gomis, M., Arboix, A., Aleu, A., Pagonabarraga, J., Belvís, R., Cocho, D., Roquer, J., Rodríguez, A., García, M. D., et al. (2004) · Stroke · doi:10.1161/01.str.0000125863.93921.3f · Cited by 192

HMG-CoA Reductase Inhibitor, Atorvastatin, Promotes Sensorimotor Recovery, Suppressing Acute Inflammatory Reaction After Experimental Intracerebral Hemorrhage

Jung, K., Chu, K., Jeong, S., Han, S.-Y., Lee, S., Kim, J., Kim, M., & Roh, J. (2004) · Stroke · doi:10.1161/01.str.0000131270.45822.85 · Cited by 191

Angiogenesis and Blood-Brain Barrier Permeability in Vascular Remodeling after Stroke

Yang, Y. R., & Torbey, M. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200720173316 · Cited by 182

Neurorestorative treatment of stroke: Cell and pharmacological approaches

Chen, J., & Chopp, M. (2006) · NeuroRx · doi:10.1016/j.nurx.2006.07.007 · Cited by 169

Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model

Yoo, S., Kim, S., Lee, S., Lee, H.-S., Kim, H.-S., Lee, Y., & Suh‐Kim, H. (2008) · Experimental & Molecular Medicine · doi:10.3858/emm.2008.40.4.387 · Cited by 167

Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke

Bonaventura, A., Liberale, L., Vecchié, A., Casula, M., Carbone, F., Dallegri, F., & Montecucco, F. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17121967 · Cited by 170

Perihematomal Edema After Intracerebral Hemorrhage: An Update on Pathogenesis, Risk Factors, and Therapeutic Advances

Chen, Y., Chen, S., Chang, J., Wei, J., Feng, M., & Wang, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.740632 · Cited by 165

Effects of AMP-Activated Protein Kinase in Cerebral Ischemia

Li, J., & McCullough, L. D. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.255 · Cited by 165

Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension

Taraseviciene‐Stewart, L., Scerbavicius, R., Choe, K., Cool, C. D., Wood, K., Tuder, R. M., Burns, N., Kasper, M. E., & Voelkel, N. F. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00491.2005 · Cited by 161

Multifunctional Drugs for Head Injury

Vink, R., & Nimmo, A. J. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.10.036 · Cited by 163

Ischemic stroke and neurogenesis in the subventricular zone

Zhang, R. L., Zhang, Z. G., & Chopp, M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.027 · Cited by 166

Neurogenesis in the Adult Ischemic Brain: Generation, Migration, Survival, and Restorative Therapy

Zhang, R. L., Zhang, Z. G., & Chopp, M. (2005) · The Neuroscientist · doi:10.1177/1073858405278865 · Cited by 160

Renal Vascular Structure and Rarefaction

Chade, A. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120012 · Cited by 157

Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity

Reitmeir, R., Kilic, E., Kilic, Ü., Bacigaluppi, M., ElAli, A., Salani, G., Pluchino, S., Gassmann, M., & Hermann, D. M. (2011) · Brain · doi:10.1093/brain/awq344 · Cited by 156

Simvastatin enhances learning and memory independent of amyloid load in mice

Li, L., Cao, D., Kim, H., Lester, R. A. J., & Fukuchi, K. (2006) · Annals of Neurology · doi:10.1002/ana.21053 · Cited by 156

Statins in Acute Ischemic Stroke: A Systematic Review

Hong, K., & Lee, J. S. (2015) · Journal of Stroke · doi:10.5853/jos.2015.17.3.282 · Cited by 150

Current and Emerging Uses of Statins in Clinical Therapeutics: A Review

Davies, J. T., Delfino, S., Feinberg, C. E., Johnson, M. F., Nappi, V. L., Olinger, J. T., Schwab, A., & Swanson, H. I. (2016) · Lipid Insights · doi:10.4137/lpi.s37450 · Cited by 156

Simvastatin enhances VEGF production and ameliorates impaired wound healing in experimental diabetes

Bitto, A., Minutoli, L., Altavilla, D., Polito, F., Fiumara, T., Marini, H. R., Galeano, M., Calò, M., Cascio, P. L., & Bonaiuto, M. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.01.005 · Cited by 148

Mechanisms of radiation-induced brain toxicity and implications for future clinical trials

Kim, J. H., Brown, S. L., Jenrow, K. A., & Ryu, S. (2008) · Journal of Neuro-Oncology · doi:10.1007/s11060-008-9520-x · Cited by 144

Cardiovascular effects of statins, beyond lipid-lowering properties

Mihos, C. G., Pineda, A. M., & Santana, O. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.02.009 · Cited by 148

Neurogenesis After Stroke: A Therapeutic Perspective

Rahman, A. A., Amruta, N., Pinteaux, E., & Bix, G. J. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00841-w · Cited by 147

Normal tissue protection for improving radiotherapy: Where are the Gaps?

Prasanna, P. G. S., Stone, H. B., Wong, R. S. L., Capala, J., Bernhard, E. J., Vikram, B., & Coleman, C. N. (2012) · PubMed · Cited by 137

Statin Treatment and Stroke Outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial

Goldstein, L. B., Amarenco, P., Zivin, J. A., Messig, M., Altafullah, I., Callahan, A. S., III, Hennerici, M. G., MacLeod, M. J., Sillesen, H. H., Zweifler, R. M., et al. (2009) · Stroke · doi:10.1161/strokeaha.109.557330 · Cited by 137

Nitric Oxide: Considerations for the Treatment of Ischemic Stroke

Terpolilli, N. A., Moskowitz, M. A., & Plesnila, N. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.12 · Cited by 139

Post‐ischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarction and improves neurological outcome in a rat model of focal cerebral ischemia

Wang, Y., Zhang, Z. G., Rhodes, K. J., Renzi, M. J., Zhang, R. L., Kapke, A., Lu, M., Pool, C., Heavner, G. A., & Chopp, M. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707285 · Cited by 135

Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis

Chen, J., Li, Y., Zhang, R., Katakowski, M., Gautam, S. C., Xu, Y., Lü, M., Zhang, Z., & Chopp, M. (2004) · Brain Research · doi:10.1016/j.brainres.2003.11.080 · Cited by 134

SIMVASTATIN ATTENUATES MICROGLIAL CELLS AND ASTROCYTE ACTIVATION AND DECREASES INTERLEUKIN-1B LEVEL AFTER TRAUMATIC BRAIN INJURY

Li, B., Mahmood, A., Lu, D., Wu, H., Xiong, Y., Qu, C., & Chopp, M. (2009) · Neurosurgery · doi:10.1227/01.neu.0000346272.76537.dc · Cited by 133

Statins and the endothelium

Ii, M., & Losordo, D. W. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2006.06.012 · Cited by 132

HMG-CoA Reductase Inhibitors Improve Acute Ischemic Stroke Outcome

Moonis, M., Kane, K., SCHWIDERSKI, U. E., Sandage, B. W., & Fisher, M. (2005) · Stroke · doi:10.1161/01.str.0000165920.67784.58 · Cited by 130

Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorrhage in rats

Seyfried, D. M., Han, Y., Lu, D., Chen, J., Bydon, A., & Chopp, M. (2004) · Journal of neurosurgery · doi:10.3171/jns.2004.101.1.0104 · Cited by 127

Neuroprotective and neuroproliferative activities of NeuroAid (MLC601, MLC901), a Chinese medicine, in vitro and in vivo

Heurteaux, C., Gandin, C., Borsotto, M., Widmann, C., Brau, F., Lhuillier, M., Onteniente, B., & Lazdunski, M. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.01.001 · Cited by 123

Angiogenesis and improved cerebral blood flow in the ischemic boundary area detected by MRI after administration of sildenafil to rats with embolic stroke

Li, L., Jiang, Q., Zhang, L., Ding, G., Zhang, Z. G., Li, Q., Ewing, J. R., Lü, M., Panda, S., Ledbetter, K. A., et al. (2007) · Brain Research · doi:10.1016/j.brainres.2006.10.098 · Cited by 119

Alzheimer's disease drugs promote neurogenesis

Jin, K., Xie, L., Mao, X. O., & Greenberg, D. A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.081 · Cited by 119

Association Between Acute Statin Therapy, Survival, and Improved Functional Outcome After Ischemic Stroke

Chróinín, D. N., Callaly, E. L., Duggan, J., Merwick, Á., Hannon, N., Sheehan, O. C., Marnane, M., Horgan, G., Williams, E. B., Harris, D., et al. (2011) · Stroke · doi:10.1161/strokeaha.110.596734 · Cited by 118

Simvastatin and Atorvastatin Improve Neurological Outcome After Experimental Intracerebral Hemorrhage

Karki, K., Knight, R. A., Han, Y., Yang, D., Zhang, J., Ledbetter, K. A., Chopp, M., & Seyfried, D. M. (2009) · Stroke · doi:10.1161/strokeaha.108.544395 · Cited by 118

Experimental treatments for acute ischaemic stroke

Sacco, R. L., Chong, J. Y., Prabhakaran, S., & Elkind, M. S. V. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60155-x · Cited by 116

Plasticity and remodeling of brain

Chopp, M., Li, Y., & Zhang, J. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.06.013 · Cited by 115

Statin treatment reduces the risk of poststroke seizures

Guo, J., Guo, J., Li, J., Zhou, M., Qin, F., Zhang, S., Wu, B., He, L., & Zhou, D. (2015) · Neurology · doi:10.1212/wnl.0000000000001814 · Cited by 114

Effects of atorvastatin on chronic subdural hematoma: A preliminary report from three medical centers

Wang, D., Li, T., Tian, Y., Wang, S., Jin, C., Wei, H., Quan, W., Wang, J., Chen, J., Dong, J., et al. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.11.005 · Cited by 114

Cholesterol and statins in Alzheimer’s disease: current controversies.

Fonseca, A. C. R. G., Resende, R., Oliveira, C. R., & Pereira, C. M. F. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.09.013 · Cited by 93

White Matter Damage and the Effect of Matrix Metalloproteinases in Type 2 Diabetic Mice After Stroke

Chen, J., Cui, X., Zacharek, A., Cui, Y., Roberts, C. J., & Chopp, M. (2010) · Stroke · doi:10.1161/strokeaha.110.596486 · Cited by 107

Atorvastatin reduction of intravascular thrombosis, increase in cerebral microvascular patency and integrity, and enhancement of spatial learning in rats subjected to traumatic brain injury

Lu, D., Mahmood, A., Goussev, A. V., Schallert, T. J., Qu, C., Zhang, Z. G., Li, Y., Lü, M., & Chopp, M. (2004) · Journal of neurosurgery · doi:10.3171/jns.2004.101.5.0813 · Cited by 107

Lipid-lowering agent use at ischemic stroke onset is associated with decreased mortality

Elkind, M. S. V., Flint, A. C., Sciacca, R. R., & Sacco, R. L. (2005) · Neurology · doi:10.1212/01.wnl.0000171746.63844.6a · Cited by 108

Niaspan increases angiogenesis and improves functional recovery after stroke

Chen, J., Cui, X., Zacharek, A., Jiang, H., Roberts, C., Zhang, C., Lu, M., Kapke, A., Feldkamp, C. S., & Chopp, M. (2007) · Annals of Neurology · doi:10.1002/ana.21160 · Cited by 105

Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease–activated receptor 1

Thiyagarajan, M., Fernández, J. A., Lane, S. M., Griffin, J. H., & Zlokovic, B. V. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3485-08.2008 · Cited by 105

Cornel iridoid glycoside promotes neurogenesis and angiogenesis and improves neurological function after focal cerebral ischemia in rats

Yao, R., Zhang, L., Wang, W., & Li, L. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.12.010 · Cited by 103

3-Hydroxy-3-methylglutaryl–Coenzyme A Reductase Inhibitors in the Treatment of Central Nervous System Diseases

Willey, J. Z., & Elkind, M. S. V. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.199 · Cited by 102

Atorvastatin Prevents Hippocampal Cell Death due to Quinolinic Acid-Induced Seizures in Mice by Increasing Akt Phosphorylation and Glutamate Uptake

Piermartiri, T., Vandresen-Filho, S., Herculano, B., Martins, W. C., Dal’Agnolo, D., Stroeh, E., Carqueja, C. L., Boeck, C. R., & Tasca, C. I. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9057-6 · Cited by 100

Comparison of biochemical effects of statins and fish oil in brain: The battle of the titans

Farooqui, A. A., Ong, W., Horrocks, L. A., Chen, P., & Farooqui, T. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.09.004 · Cited by 100

Differential effect of endothelial nitric oxide synthase (NOS‐III) on the regulation of adult neurogenesis and behaviour

Reif, A., Schmitt, A. G., Fritzen, S., Chourbaji, S., Bartsch, C., Urani, A., Wycislo, M., Mößner, R., Sommer, C., Gass, P., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03559.x · Cited by 101

Brain repair: cell therapy in stroke

Kalladka, D., & Muir, K. W. (2014) · Stem Cells and Cloning Advances and Applications · doi:10.2147/sccaa.s38003 · Cited by 101

Cell-based and pharmacological neurorestorative therapies for ischemic stroke

Venkat, P., Shen, Y., Chopp, M., & Chen, J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.036 · Cited by 99

The role of angiogenesis in damage and recovery from ischemic stroke

Arenillas, J. F., Sobrino, T., Castillo, J., & Dávalos, A. (2007) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-007-0014-5 · Cited by 99

Effects of erythropoietin on reducing brain damage and improving functional outcome after traumatic brain injury in mice

Xiong, Y., Lu, D., Qu, C., Goussev, A. V., Schallert, T. J., Mahmood, A., & Chopp, M. (2008) · Journal of neurosurgery · doi:10.3171/jns/2008/109/9/0510 · Cited by 98

Statins — a cure-all for the brain?

Menge, T., Hartung, H.-P., & Stüve, O. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1652 · Cited by 98

Caspase-3 Modulates Regenerative Response After Stroke

Fan, W., Dai, Y., Xu, H., Zhu, X., Cai, P., Wang, L., Sun, C., Hu, C., Zheng, P., & Zhao, B. (2013) · Stem Cells · doi:10.1002/stem.1503 · Cited by 100

Chemokine, vascular and therapeutic effects of combination Simvastatin and BMSC treatment of stroke

Cui, X., Chopp, M., Zacharek, A., Roberts, C. J., Lü, M., Savant‐Bhonsale, S., & Chen, J. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.012 · Cited by 93

Gene expression changes after focal stroke, traumatic brain and spinal cord injuries

Carmichael, S. T. (2003) · Current Opinion in Neurology · doi:10.1097/00019052-200312000-00009 · Cited by 92

Thymosin β4 improves functional neurological outcome in a rat model of embolic stroke

Morris, D. C., Chopp, M., Zhang, L., Lü, M., & Zhang, Z. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.017 · Cited by 92

Iron, Atherosclerosis, and Neurodegeneration: A Key Role for Cholesterol in Promoting Iron‐Dependent Oxidative Damage?

Ong, W.-Y., & Halliwell, B. B. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.005 · Cited by 89

Statins in Traumatic Brain Injury

Wible, E. F., & Laskowitz, D. T. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2009.11.003 · Cited by 88

Simvastatin therapy prevents brain trauma‐induced increases in β‐amyloid peptide levels

Abrahamson, E. E., Ikonomović, M. D., Dixon, C. E., & DeKosky, S. T. (2009) · Annals of Neurology · doi:10.1002/ana.21731 · Cited by 89

Role of Histamine and Its Receptors in Cerebral Ischemia

Hu, W., & Chen, Z. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn200126p · Cited by 87

Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury

Wu, H., Lu, D., Jiang, H., Xiong, Y., Qu, C., Лі, Б., Mahmood, A., Zhou, D., & Chopp, M. (2008) · Journal of neurosurgery · doi:10.3171/jns/2008/109/10/0691 · Cited by 84

Neuronal Nitric Oxide Synthase and Ischemia-Induced Neurogenesis

Sun, Y., Jin, K., Childs, J., Xie, L., Mao, X. O., & Greenberg, D. A. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600049 · Cited by 84

Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment

Franke, C., Nöldner, M., Abdel-Kader, R. M., Johnson‐Anuna, L. N., Wood, W. G., Müller, W. E., & Eckert, G. P. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.10.004 · Cited by 83

CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke

Gutiérrez‐Fernández, M., Rodríguez‐Frutos, B., Fuentes, B., Vallejo‐Cremades, M. T., Álvarez-Grech, J., Expósito-Alcaide, M., & Díez‐Tejedor, E. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.12.015 · Cited by 80

Effects of intravenous administration of human bone marrow stromal cells after intracerebral hemorrhage in rats

Seyfried, D. M., Ding, J., Han, Y., Li, Y., Chen, J., & Chopp, M. (2006) · Journal of neurosurgery · doi:10.3171/jns.2006.104.2.313 · Cited by 79

New neurons in adult brain: distribution, molecular mechanisms and therapies

Pino, A., Fumagalli, G. F., Bifari, F., & Decimo, I. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.07.003 · Cited by 83

Atorvastatin and Myocardial Reperfusion Injury

Efthymiou, C. A., Mocanu, M. M., & Yellon, D. M. (2005) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000154376.82445.06 · Cited by 79

Delayed Thrombosis after Traumatic Brain Injury in Rats

Lu, D., Mahmood, A., Goussev, A. V., Qu, C., Zhang, Z. G., & Chopp, M. (2004) · Journal of Neurotrauma · doi:10.1089/0897715042664885 · Cited by 77

Delayed Statin Therapy following Experimental Stroke Induces Angiogenesis, Neurogenesis and Synaptogenesis and Promotes Functional Recovery

Connolly, E. S. (2003) · Neurosurgery · doi:10.1227/01.neu.0000309245.41236.e2

Atorvastatin Induction of VEGF and BDNF Promotes Brain Plasticity after Stroke in Mice

Chen, J., Zhang, C., Jiang, H., Li, Y., Zhang, L., Robin, A. M., Katakowski, M., Lü, M., & Chopp, M. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600034 · Cited by 451

HMG-CoA Reductase Inhibition Promotes Neurological Recovery, Peri-Lesional Tissue Remodeling, and Contralesional Pyramidal Tract Plasticity after Focal Cerebral Ischemia

Kılıç, E., Reitmeir, R., Kılıç, Ü., Çağlayan, A. B., Beker, M. Ç., Keleştemur, T., Ethemoğlu, S., Öztürk, G., & Hermann, D. M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00422 · Cited by 23

Efecto terapéutico de las estatinas en patología degenerativa del SNC: comentario sobre una publicación experimental reciente

Rommy von Bernhardi, M. (2003) · Revista chilena de neuro-psiquiatría · doi:10.4067/s0717-92272003000400005

Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorrhage in rats

Seyfried, D. M., Han, Y., Lu, D., Chen, J., Bydon, A., & Chopp, M. (2004) · Journal of neurosurgery · doi:10.3171/jns.2004.101.1.0104 · Cited by 127