Cited by 596Stroke Rehabilitation and RecoveryNeurogenesis and neuroplasticity mechanismsAcute Ischemic Stroke Management

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

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Zhang, Zheng Gang, Chopp, Michael·2009·The Lancet Neurology

Abstract

Restorative cell-based and pharmacological therapies for experimental stroke substantially improve functional outcome. These therapies target several types of parenchymal cells (including neural stem cells, cerebral endothelial cells, astrocytes, oligodendrocytes, and neurons), leading to enhancement of endogenous neurogenesis, angiogenesis, axonal sprouting, and synaptogenesis in the ischaemic brain. Interaction between these restorative events probably underpins the improvement in functional outcome. This Review provides examples of cell-based and pharmacological restorative treatments for stroke that stimulate brain plasticity and functional recovery. The molecular pathways activated by these therapies, which induce remodelling of the injured brain via angiogenesis, neurogenesis, and axonal and dendritic plasticity, are discussed. The ease of treating intact brain tissue to stimulate functional benefit in restorative therapy compared with treating injured brain tissue in neuroprotective therapy might more readily help with translation of restorative therapy from the laboratory to the clinic.

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  1. [129]Ding G Jiang Q Li L Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats J Cereb Blood Flow Metab 2008 28 1440 48 18418368 PMC2575653

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Authors
Zhang, Z. G., & Chopp, M.
Affiliations
  • Henry Ford Health (US)
  • Oakland University (US)
Corresponding author
Chopp, Michael
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2009-05
Volume
8
Issue
5
Pages
491-500
ISSN
1474-4422 (ISSN-L)
OpenAlex
W2121567769
Cited by
596
References
152
Citations by year
2026: 8 · 2025: 16 · 2024: 19 · 2023: 26 · 2022: 20 · 2021: 26 · 2020: 35 · 2019: 32 · 2018: 43 · 2017: 34 · 2016: 41 · 2015: 49 · 2014: 50 · 2013: 63 · 2012: 53
FWCI
5.86
Type
journal article
Language
en
Open access
Locations
  • The Lancet Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL064766, R01HL64766)
  • National Institute of Neurological Disorders and Stroke (P01 NS23392, P01NS42345, P50NS023393, P01NS042345)
Topics
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
stroke, cell therapy, pharmacotherapy, neurogenesis, angiogenesis, axonal sprouting, synaptogenesis, neuroplasticity, functional recovery, neural stem cells, brain endothelial cells, astrocytes, oligodendrocytes, neuroprotection
MeSH terms
Animals, Astrocytes, Axons, Brain, Clinical Trials as Topic, Humans, Neuronal Plasticity, Oligodendroglia, Neuroprotective Agents, Neovascularization, Physiologic, Recovery of Function, Stroke, Neurogenesis

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