Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke
Abstract
This article analyzes the mechanisms underlying the potentiation of functional recovery poststroke by cell-based and pharmacologic agents, which amplify endogenous neurogenesis in the subventricular zone and angiogenesis in the border of the ischemic lesion in the animal. Discussion of the interaction between angiogenesis and neurogenesis is provided and data are described demonstrating a role for matrix metalloproteinases expressed in periinfarct vasculature as chemotactic for neuroblasts migrating from the subventricular zone. Monitoring angiogenesis and structural changes in the ischemic brain associated with functional recovery by means of MRI is described. We demonstrate that injured brain can be stimulated to promote angiogenesis and neurogenesis, which are coupled restorative processes that contribute to functional recovery from stroke and that MRI indices of these neurorestorative events are highly correlative with neurologic function and may be used in real-time monitoring of recovery from stroke.
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In peri-infarct tissue, newly formed vessels create a milieu for migration, homing, and neuronal differentiation of neuroblasts via release of SDF1, VEGF, and MMP2/9, which attract neuroblasts.
“In the peri-infarct tissue, newly formed vessels create a milieu for the migration, homing, and neuronal differentiation of neuroblasts via release of stromal derived factor 1, VEGF, and matrix metalloproteinases 2 and 9, which attract neuroblasts.58,59”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [59]
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Self-citation
- Authors
- Chopp, M., Zhang, Z. G., & Jiang, Q.
- Affiliations
- Henry Ford Health (US)
- Venue
- Stroke
- Published
- 2007-02
- Volume
- 38
- Issue
- 2
- Pages
- 827-831
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2047647123
- Cited by
- 203
- References
- 82
- Citations by year
- 2026: 1 · 2025: 5 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 10 · 2019: 14 · 2018: 8 · 2017: 12 · 2016: 14 · 2015: 9 · 2014: 19 · 2013: 16 · 2012: 26
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Stroke
- Funders
- National Heart, Lung, and Blood Institute (R01HL064766, R01HL64766)
- National Institute of Neurological Disorders and Stroke (P01NS23393, P01NS023393, R01NS043324, P01NS042345, R01 NS 43324)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- functional recovery, neurogenesis, angiogenesis, subventricular zone, matrix metalloproteinases, neuroblast migration, ischemic lesions, neurorestoration, cell therapy, pharmacologic agents, recovery monitoring
- MeSH terms
- Animals, Humans, Magnetic Resonance Imaging, Neovascularization, Pathologic, Recovery of Function, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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