The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Contribution of the ipsilateral motor cortex to recovery after chronic stroke
Abstract
It has been proposed that the intact (ipsilateral) motor cortex play a significant role mediating recovery of motor function in the paretic hand of chronic stroke patients, but this hypothesis has not been tested experimentally. Here, we evaluated the effects of transcranial magnetic stimulation (TMS) on motor performance of the paretic hand of chronic stroke patients and healthy controls. We hypothesized that, if activity in the intact hemisphere contributes to functional recovery, TMS should result in abnormal motor behavior in the paretic hand. We found that stimulation of the intact hemisphere resulted in delayed simple reaction times (RTs) in the contralateral healthy but not in the ipsilateral paretic hand, whereas stimulation of the lesioned hemisphere led to a marked delay in RT in the contralateral paretic hand but not in the ipsilateral healthy hand. RT delays in the paretic hand correlated well with functional recovery. Finger tapping in the paretic hand was affected by TMS of the lesioned but not the intact hemisphere. These results are consistent with the idea that recovered motor function in the paretic hand of chronic stroke patients relies predominantly on reorganized activity within motor areas of the affected hemisphere.
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Cites
Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation
Chen, R., Classen, J., Gerloff, C., Celnik, P., Wassermann, E. M., Hallett, M., & Cohen, L. G. (1997) · Neurology · doi:10.1212/wnl.48.5.1398 · Cited by 2,128 · cited 2×
“Second, application of 1Hz TMS for 30 minutes at 50% above rMT, as implemented in experiment 3, leads to transient and reversible downregulation of cortical activity in the underlying cortical structures that outlasts the stimulation period for several minutes.(11) We took advantage of this property of the TMS paradig…”
BackgroundMethodSelf-citationNudo, R. J., Wise, B. M., SiFuentes, F., & Milliken, G. W. (1996) · Science · doi:10.1126/science.272.5269.1791 · Cited by 1,911
Rapid plasticity of human cortical movement representation induced by practice
Classen, J., Liepert, J., Wise, S. P., Hallett, M., & Cohen, L. G. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.2.1117 · Cited by 1,156
Self-citationPascual-Leone, A. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00081-7 · Cited by 923
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Cited by
The plastic human brain cortex
Pascual-Leone, A., Amedi, A., Fregni, F., & Merabet, L. B. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144216 · Cited by 1,929
Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery
Cramer, S. C. (2008) · Annals of Neurology · doi:10.1002/ana.21393 · Cited by 875
Cellular and molecular mechanisms of neural repair after stroke: making waves
Carmichael, S. T. (2006) · Annals of Neurology · doi:10.1002/ana.20845 · Cited by 595
Gerloff, C., Bushara, K., Sailer, A., Wassermann, E. M., Chen, R., Matsuoka, T., Waldvogel, D., Wittenberg, G. F., Ishii, K., Cohen, L. G., et al. (2006) · Brain · doi:10.1093/brain/awh713 · Cited by 452
Self-citationBrown, C. E., Li, P., Boyd, J. D., Delaney, K. R., & Murphy, T. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4295-06.2007 · Cited by 377
Metadata
- Authors
- Werhahn, K. J., Conforto, A. B., Kadom, N., Hallett, M., & Cohen, L. G.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2003-08-11
- Volume
- 54
- Issue
- 4
- Pages
- 464-472
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2059331478
- Cited by
- 266
- References
- 5
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Werhahn, K. J., Conforto, A. B., Kadom, N., Hallett, M., & Cohen, L. G. (2003). Contribution of the ipsilateral motor cortex to recovery after chronic stroke. Annals of Neurology. https://doi.org/10.1002/ana.10686
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
