The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Apolipoprotein E–dependent accumulation of Alzheimer disease–related lesions begins in middle age
Abstract
Objective: To study the prevalence and age dependency of senile plaques (SP) and neurofibrillary tangles (NFT), the brain changes characteristic of Alzheimer disease (AD), and their association with apolipoprotein E (APOE) genotypes in a community‐dwelling normal population. Methods: This neuropathological study used both silver staining and Aβ immunohistochemistry in brain tissue microarrays, including SP coverage and NFT counts from frontal cortex and hippocampus, and APOE genotyping, and was performed on a consecutive prospective series of 603 subjects (aged between 0 and 97 years) of an unselected population living outside of institutions. Cases were subjected to autopsy following sudden or unexpected out‐of‐hospital death, covering 22.1% of the mortality of Tampere, Finland and its surroundings. None died of AD, although 22 (3.7%) were demented and 10 (1.7%) had memory problems. Results: Of the series, 30.8% had SP, and 42.1% had NFT; these occurred more commonly among females and showed a strong relationship with age. Both changes had already appeared at around 30 years of age, reaching an occurrence of almost 100% in the oldest. SP were more frequent in APOE ϵ4‐carriers compared with noncarriers in every age group except the oldest (>90 years). The difference was most evident during the ages 50 to 59 years, where 40.7% of ϵ4‐carriers had SP, compared with 8.2% in noncarriers (odds ratio, 8.39; 95% confidence interval, 2.55–27.62). The difference in NFT prevalence between APOE genotypes was not statistically significant in any age group. Interpretation: The brain changes associated with AD may already begin developing early in middle age, especially among APOE ϵ4 carriers. Ann Neurol 2009;65:650–657
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There is strong experimental evidence that the APOE isoforms are major determinants of the amount and quality of amyloid-β peptide (Aβ) and amyloid burden in the brain that develops during aging.15–17”
From AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease (2018) · cites this paper as [17]
In the citing paper
“In AD, its specific role in promoting β-amyloid (Aβ) plaque pathology is, however, well established (Fleisher et al, 2013; Kok et al, 2009; Murphy et al, 2013; Schmechel et al, 1993).”
From APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia (2024) · cites this paper as Kok et al, 2009
In the citing paper
“In AD patients, APOE4 enhances Aβ deposition, where 40.7% of middle-aged APOE ε4 carriers featured senile plaques, compared to 8.2% non-carriers identified with senile plaques [459].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [459]
Citations
Cites
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Tissue microarrays for high-throughput molecular profiling of tumor specimens
Kononen, J., Bubendorf, L., Kallionimeni, A., Barlund, M. T., Schraml, P., Leighton, S. B., Torhorst, J. K. H., Mihatsch, M. J., Sauter, G., & Kallionimeni, O.-P. (1998) · Nature Medicine · doi:10.1038/nm0798-844 · Cited by 4,101
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920
Apolipoprotein E: Far More Than a Lipid Transport Protein
Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836
Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories
Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656
(2001) · The Lancet · doi:10.1016/s0140-6736(00)03589-3 · Cited by 1,338
Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E.-L., Tuomilehto, J., Soininen, H., & Nissinen, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1556 · Cited by 1,291
Braak, F., Braak, H., & Mandelkow, E. (1994) · Acta Neuropathologica · doi:10.1007/bf00293315 · Cited by 769
Research works printed but not linked: 1
- O'Brien J, 2000, Dementia
Cited by
Sorted by citations
Items 101–200 of 299
[Metabolic difference between visceral fat and subcutaneous abdominal fat].
Björntorp, P. A. (2000) · PubMed · Cited by 60
The spectrum of preclinical Alzheimer's disease pathology and its modulation by ApoE genotype
Pletniková, O., Kageyama, Y., Rudow, G. L., LaClair, K. D., Albert, M., Crain, B. J., Tian, J., Fowler, D. R., & Troncoso, J. C. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.07.007 · Cited by 57
Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions
Jin, M., & Cai, S. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00969-9 · Cited by 61
Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer’s Disease
Sternberg, Z., Hu, Z., Sternberg, D. S., Waseh, S., Quinn, J. F., Wild, K., Kaye, J. A., Zhao, L., & Garrick, M. D. (2017) · Aging and Disease · doi:10.14336/ad.2016.0811 · Cited by 57
Seizure in Alzheimer’s Disease: An Underestimated Phenomenon
Asadollahi, M., Atazadeh, M., & Noroozıan, M. (2018) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317518813551 · Cited by 56
Longitudinal relationships among biomarkers for Alzheimer disease in the Adult Children Study
Xiong, C., Jasielec, M. S., Weng, H., Fagan, A. M., Benzinger, T. L. S., Head, D., Hassenstab, J., Grant, E., Sutphen, C. L., Buckles, V., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002593 · Cited by 54
Interactions of metals and Apolipoprotein E in Alzheimer’s disease
Xu, H. J., Finkelstein, D. I., & Adlard, P. A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00121 · Cited by 56
Jiang, Y., Zhou, X., Wong, H. Y., Ouyang, L., Ip, F. C. F., Chau, V. M. N., Lau, S., Wu, W., Wong, D. Y. K., Seo, H., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00241-9 · Cited by 56
Mahley, R. W., & Huang, Y. (2009) · Annals of Neurology · doi:10.1002/ana.21736 · Cited by 53
Bangen, K. J., Initiative, F. T. A. D. N., Clark, A. L., Werhane, M., Edmonds, E. C., Nation, D. A., Evangelista, N., Libon, D. J., Bondi, M. W., & Delano-Wood, L. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-150900 · Cited by 51
The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample
Postupna, N. O., Rose, S. E., Gibbons, L. E., Coleman, N., Hellstern, L. L., Ritchie, K., Wilson, A. M., Cudaback, E., Li, X., Melief, E. J., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.624696 · Cited by 51
Initiative, A. D. N., Liu, Y., Tan, L., Wang, H.-F., Liu, Y., Hao, X., Tan, C., Jiang, T., Liu, B., Zhang, D., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9388-7 · Cited by 54
Leoni, V., & Caccia, C. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.03.015 · Cited by 48
Alzheimer's Disease: Another Target for Heparin Therapy
Bergamaschini, L. C., Rossi, E., Vergani, C., & Simoni, M. G. D. (2009) · The Scientific World JOURNAL · doi:10.1100/tsw.2009.100 · Cited by 46
Increased florbetapir binding in the temporal neocortex from age 20 to 60 years
Gonneaud, J., Arenaza‐Urquijo, E. M., Mézenge, F., Landeau, B., Gaubert, M., Bejanin, A., de Florès, R., Wirth, M., Tomadesso, C., Poisnel, G., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004733 · Cited by 49
Lewczuk, P., Popp, J., Lelental, N., Kölsch, H., Maier, W., Kornhuber, J., & Jessen, F. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-110857 · Cited by 44
Common Genetic Variants Associated with Sudden Cardiac Death: The FinSCDgen Study
Lahtinen, A. M., Noseworthy, P. A., Havulinna, A. S., Jula, A., Karhunen, P. J., Kettunen, J., Perola, M., KONTULA, K. K., Newton‐Cheh, C., & Salomaa, V. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041675 · Cited by 44
Self-citationDong, Q., Zhang, W., Wu, J., Li, B., Schron, E. H., McMahon, T., Shi, J., Gutman, B. A., Chen, K., Baxter, L. C., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101744 · Cited by 44
Schmitz, T. W., Soreq, H., Poirier, J., & Spreng, R. N. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1184-19.2019 · Cited by 47
Mormino, E. C. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9267-4 · Cited by 44
Nielsen, H. M., Chen, K., Lee, W., Chen, Y., Bauer, R. J., III, Reiman, E. M., Caselli, R. J., & Bu, G. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-016-0231-9 · Cited by 44
Toxoplasma gondii: A possible etiologic agent for Alzheimer's disease
Nayeri, T., Sarvi, S., Sharif, M., & Daryani, A. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07151 · Cited by 46
Cholesterol Dysmetabolism in Alzheimer’s Disease: A Starring Role for Astrocytes?
Staurenghi, E., Giannelli, S., Testa, G., Sottero, B., Leonarduzzi, G., & Gamba, P. (2021) · Antioxidants · doi:10.3390/antiox10121890 · Cited by 44
Kim, S. E., Kim, H. J., Jang, H., Weiner, M. W., DeCarli, C. S., Na, D. L., & Seo, S. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810490 · Cited by 42
An olfactory ‘stress test’ may detect preclinical Alzheimer’s disease
Schofield, P. W., Ebrahimi, H., Jones, A. L., Bateman, G. A., & Murray, S. R. (2012) · BMC Neurology · doi:10.1186/1471-2377-12-24 · Cited by 43
HSV presence in brains of individuals without dementia: the TASTY brain series
Olsson, J., Lövheim, H., Honkala, E., Karhunen, P. J., Elgh, F., & Kok, E. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.026674 · Cited by 43
Self-citationAssessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer’s disease
Patra, K., Soosaipillai, A. R., Sando, S. B., Lauridsen, C., Berge, G., Møller, I., Grøntvedt, G. R., Bråthen, G., Begcevic, I., Moussaud, S., et al. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0336-4 · Cited by 45
McMillan, I. O., Li, J., & Wang, L. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00247.2022 · Cited by 49
Neuronal ApoE4 in Alzheimer’s disease and potential therapeutic targets
Zhang, L., Xia, Y., & Gui, Y. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1199434 · Cited by 41
The pleiotropic vasoprotective functions of high density lipoproteins (HDL)
Boyce, G. K., Button, E. B., Sonja, S. V., & Wellington, C. L. (2017) · Journal of Biomedical Research · doi:10.7555/jbr.31.20160103 · Cited by 41
The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older
Izaks, G. J., Gansevoort, R. T., van der Knaap, A. M., Navis, G. J., Dullaart, R. P. F., & Slaets, J. P. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027415 · Cited by 42
Neuroinflammation in Alzheimer’s Disease: Microglia, Molecular Participants and Therapeutic Choices
Wang, H., Shen, Y., Chuang, H.-Y., Chiu, C., Ye, Y., & Zhao, L. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190503151648 · Cited by 43
Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice
Giannisis, A., Patra, K., Edlund, A. K., Nieto, L. A., Benedicto-Gras, J., Moussaud, S., de la Rosa, A., Twohig, D., Bengtsson, T., Fu, Y., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01548-0 · Cited by 40
Recent Aspects of Periodontitis and Alzheimer’s Disease—A Narrative Review
Cichońska, D., Mazuś, M., & Kusiak, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052612 · Cited by 47
Sugarman, M. A., Woodard, J. L., Nielson, K. A., Seidenberg, M., Smith, J. C., Durgerian, S., & Rao, S. M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.09.016 · Cited by 41
Longitudinal validity of PET‐based staging of regional amyloid deposition
Jelistratova, I., Teipel, S. J., & Grothe, M. J. (2020) · Human Brain Mapping · doi:10.1002/hbm.25121 · Cited by 39
Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms
Jung, M., & Metzger, D. (2010) · Molecules · doi:10.3390/molecules15074984 · Cited by 47
Prasanth, M. I., Malar, D. S., Tencomnao, T., & Brimson, J. M. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1939681 · Cited by 40
Stephan, B. C. M., Matthews, F. E., Ma, B., Terrera, G. M., Hunter, S., Davis, D. H. J., McKeith, I. G., Foster, G., Ince, P. G., & Brayne, C. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110518 · Cited by 40
Immunotherapeutic approaches for Alzheimer’s disease in transgenic mouse models
Wısnıewskı, T., & Boutajangout, A. (2009) · Brain Structure and Function · doi:10.1007/s00429-009-0236-2 · Cited by 39
Pilotto, F., Schmitz, A., Maharjan, N., Diab, R., Odriozola, A., Tripathi, P., Yamoah, A., Scheidegger, O., Oestmann, A., Dennys, C. N., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02494-5 · Cited by 36
Methylglyoxal in the Brain: From Glycolytic Metabolite to Signalling Molecule
Yang, Z., Zhang, W., Han, L., & Cai, S. (2022) · Molecules · doi:10.3390/molecules27227905 · Cited by 36
APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus
Pyykkö, O. T., Helisalmi, S., Koivisto, A. M., Mölsä, J. A. A., Rummukainen, J. K., Nerg, O., Alafuzoff, I. I., Savolainen, S., Soininen, H. S., Jääskeläinen, J. E., et al. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-303849 · Cited by 38
Nock, T. G., Chouinard‐Watkins, R., & Plourde, M. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.07.004 · Cited by 37
Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β
Chai, A. B., Lam, H. H. J., Kockx, M., & Gelissen, I. C. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158980 · Cited by 41
Zhang, W., Hu, C., Yang, Z., Zhou, Q., Peng, D., Yuan, X., Lv, Z., Pang, S., Jiang, W., Yang, C., et al. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.130117 · Cited by 36
Human Brain Reacts to Transcranial Extraocular Light
Sun, L., Peräkylä, J., Kovalainen, A., Ogawa, K. H., Karhunen, P. J., & Hartikainen, K. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149525 · Cited by 36
Self-citationLima, D., Hacke, A. C. M., Inaba, J., Pessôa, C. A., & Kerman, K. (2019) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2019.107447 · Cited by 37
Kagerer, S. M., Bergen, J. M. G. V., Li, X., Quevenco, F. C., Gietl, A. F., Studer, S. T., Treyer, V., Meyer, R., Kaufmann, P. A., Nitsch, R. M., et al. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12002 · Cited by 37
Jablonski, A. M., Warren, L., Usenovic, M., Zhou, H. H., Sugam, J. A., Parmentier‐Batteur, S., & Voleti, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-82901-1 · Cited by 38
Blackman, J., Love, S., Sinclair, L. I., Cain, R., & Coulthard, E. J. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-00992-y · Cited by 37
CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques
Kok, E., Luoto, T. M., Haikonen, S., Goebeler, S., Haapasalo, H. K., & Karhunen, P. J. (2011) · Alzheimer s Research & Therapy · doi:10.1186/alzrt71 · Cited by 36
Self-citationA History of Senile Plaques: From Alzheimer to Amyloid Imaging
Beach, T. G. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac030 · Cited by 37
Longitudinal change in working memory as a function of APOE genotype in midlife and old age
Greenwood, P. M., Espeseth, T., Lin, M., Reinvang, I., & Parasuraman, R. (2014) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12123 · Cited by 37
Preman, P., Moechars, D., Fertan, E., Wolfs, L., Serneels, L., Shah, D., Lamote, J., Poovathingal, S., Snellinx, A., Mancuso, R., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00162-7 · Cited by 32
Matura, S., Prvulovic, D., Butz, M., Hartmann, D., Sepanski, B., Linnemann, K., Oertel‐Knöchel, V., Karakaya, T., Fußer, F., Pantel, J., et al. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12659 · Cited by 32
Iacono, D., & Feltis, G. C. (2019) · Aging · doi:10.18632/aging.101757 · Cited by 36
Variability in objective sleep is associated with Alzheimer’s pathology and cognition
Fenton, L. E., Isenberg, A. L., Aslanyan, V., Albrecht, D., Contreras, J. A., Stradford, J., Monreal, T. K., & Pa, J. (2023) · Brain Communications · doi:10.1093/braincomms/fcad031 · Cited by 31
Kim, E., Lee, S. H., Lee, K. S., Cheong, H., Namkoong, K., Hong, C. H., & Oh, B. H. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.005 · Cited by 31
Alzheimer’s disease: diagnostics, prognostics and the road to prevention
Grossman, I., Lutz, M. W., Crenshaw, D. G., Saunders, A. M., Burns, D. K., & Roses, A. D. (2010) · EPMA Journal · doi:10.1007/s13167-010-0024-3 · Cited by 37
Wijesinghe, P., Shankar, S. K., Yasha, T. C., Gorrie, C. A., Amaratunga, D., Hulathduwa, S., Kumara, K. S., Samarasinghe, K., Suh, Y., Steinbusch, H. W. M., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160425 · Cited by 30
Popp, J., Lewczuk, P., Frommann, I., Kölsch, H., Kornhuber, J., Maier, W., & Jessen, F. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100561 · Cited by 36
Kok, E., Karppinen, T. T., Luoto, T. M., Alafuzoff, I. I., & Karhunen, P. J. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13102 · Cited by 27
Self-citationPlasma amyloid and tau as dementia biomarkers in Down syndrome: Systematic review and meta‐analyses
Alhajraf, F., Ness, D., Hye, A., & Strydom, A. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22715 · Cited by 27
Prospects of Saffron and its Derivatives in Alzheimer’s Disease
Zandi, N., Pazoki, B., Roudsari, N. M., Lashgari, N., Jamshidi, V., Momtaz, S., Abdolghaffari, A. H., & Akhondzadeh, S. (2021) · Archives of Iranian Medicine · doi:10.34172/aim.2021.35 · Cited by 25
Mountaki, C., Dafnis, I., Panagopoulou, E. A., Vasilakopoulou, P. B., Karvelas, M., Chiou, A., Karathanos, V. Τ., & Chroni, A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.022 · Cited by 28
Sutherland, G. T., Siebert, G. A., Kril, J. J., & Mellick, G. D. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110026 · Cited by 26
Appraisal of Cognition in Preclinical Alzheimer’s Disease: A Conceptual Review
Knopman, D. S., & Caselli, R. J. (2012) · Neurodegenerative Disease Management · doi:10.2217/nmt.12.5 · Cited by 29
Hunter, L. E., Freudenberg‐Hua, Y., Davies, P., Kim, M., Lipton, R. B., Stewart, W. F., Srinivasan, P., Hu, S., & Lipton, M. L. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2019.4828 · Cited by 26
Associations Between APOE Variants, Tau and α-Synuclein
Rodriguez‐Vieitez, E., & Nielsen, H. M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9358-8_15 · Cited by 24
The Use of Patient-Derived Induced Pluripotent Stem Cells for Alzheimer’s Disease Modeling
Lee, C., Willerth, S. M., & Nygaard, H. B. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101804 · Cited by 24
Bilingualism as a Contributor to Cognitive Reserve: What it Can do and What it Cannot do
Berkes, M., & Bialystok, E. (2022) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175221091417 · Cited by 26
Uchida, Y., Onda, K., Hou, Z., Troncoso, J. C., Mori, S., & Oishi, K. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230452 · Cited by 23
Affuso, F., Micillo, F., & Fazio, S. (2024) · Biomedicines · doi:10.3390/biomedicines12081888 · Cited by 25
Linking Diabetes to Alzheimer’s Disease: Potential Roles of Glucose Metabolism and Alpha-Glucosidase
Wee, A. S., Nhu, T. D., Khaw, K. Y., Tang, K. S., & Yeong, K. Y. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21999221111102343 · Cited by 24
den Heijer, T., van der Lijn, F., Ikram, M. A., Koudstaal, P. J., van der Lugt, A., Krestin, G. P., Vrooman, H. A., Albert Hofman, D., Niessen, W. J., & Breteler, M. M. B. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.07.005 · Cited by 22
Isotalo, K., Kok, E., Luoto, T., Haikonen, S., Haapasalo, H., Lehtimäki, T., & Karhunen, P. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2012.00586.x · Cited by 24
Self-citationLahtinen, A. M., Havulinna, A. S., Noseworthy, P. A., Jula, A., Karhunen, P. J., Perola, M., Newton‐Cheh, C., Salomaa, V. V., & KONTULA, K. K. (2013) · Annals of Medicine · doi:10.3109/07853890.2013.783995 · Cited by 21
Self-citationCognitively Normal APOE ε4 Carriers Have Specific Elevation of CSF SNAP-25
Butt, O. H., Long, J. M., Henson, R. L., Herries, E. M., Sutphen, C. L., Fagan, A. M., Cruchaga, C., Ladenson, J. H., Holtzman, D. M., Morris, J. C., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.02.008 · Cited by 21
Zhang, T., Wang, S., & Niu, Q. L. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-9995-6 · Cited by 20
Woodard, J. L., & Sugarman, M. A. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_159 · Cited by 20
Gläser, E., Kilimann, I., Platen, M., Hoffmann, W. U., Brosseron, F., Büerger, K., Coenjaerts, M., Düzel, E., Ewers, M., Fließbach, K., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01785-9 · Cited by 19
Llibre‐Guerra, J. J., Iaccarino, L., Coble, D., Edwards, L., Li, Y., McDade, E., Strom, A., Gordon, B. A., Mundada, N. S., Schindler, S. E., et al. (2023) · Brain Communications · doi:10.1093/braincomms/fcad280 · Cited by 21
APOE genotype and sex modulate Alzheimer’s disease pathology in aged EFAD transgenic mice
Balu, D., Valencia‐Olvera, A. C., Islam, Z., Mielczarek, C., Hansen, A. L., Ramos, T. M. P., York, J. M., LaDu, M. J., & Tai, L. M. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1279343 · Cited by 20
A cortical form of CADASIL with cerebral Aβ amyloidosis
Paquet, C., Jouvent, É., Miné, M., Vital, A., Hugon, J., Chabriat, H., & Gray, F. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0758-y · Cited by 19
Franco, R., Navarro, G., & Martínez‐Pinilla, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133297 · Cited by 17
Stonnington, C. M., Velgos, S. N., Chen, Y., Syed, S., Huentelman, M. J., Thiyyagura, P., Lee, W., Richholt, R., Caselli, R. J., Locke, D. E. C., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200132 · Cited by 18
APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid1
Berger, M., Cooter, M., Roesler, A. S., Chung, S., Park, J., Modliszeski, J. L., VanDusen, K. W., Thompson, J. W., Moseley, M. A., Devinney, M. J., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200747 · Cited by 15
CRP gene variation affects early development of Alzheimer's disease-related plaques
Kok, E., Alanne-Kinnunen, M., Isotalo, K., Luoto, T., Haikonen, S., Goebeler, S., Perola, M., Hurme, M. A., Haapasalo, H., & Karhunen, P. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-96 · Cited by 16
Self-citationApolipoprotein E allelotype is associated with neuropathological findings in Alzheimer's disease
Kumar, N. T., Liestøl, K., Løberg, E. M., Reims, H. M., & Mæhlen, J. (2015) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-015-1772-1 · Cited by 16
Characterization of Amyloid-β Deposits in Bovine Brains
Costassa, E. V., Fiorini, M., Zanusso, G., Peletto, S., Acutis, P. L., Baioni, E., Maurella, C., Tagliavini, F., Catania, M., Gallo, M., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151007 · Cited by 16
Exacerbated CSF abnormalities in younger patients with Alzheimer's disease
Dumurgier, J., Gabelle, A., Vercruysse, O., Bombois, S., Laplanche, J., Peoc’h, K., Schraen‐Maschke, S., Sablonnière, B., Pasquier, F., Touchon, J., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.01.023 · Cited by 17
ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease
Vossel, K. A., Bien‐Ly, N., Bernardo, A., Rascovsky, K., Karydas, A., Rabinovici, G. D., Sidhu, M., Huang, E. J., Miller, B. L., Huang, Y., et al. (2012) · Neurocase · doi:10.1080/13554794.2012.667124 · Cited by 16
Noroozıan, M. (2015) · Neurologic Clinics · doi:10.1016/j.ncl.2015.08.005 · Cited by 18
The EMAS Study Group, Overman, M. J., Pendleton, N., O’Neill, T. W., Bártfai, G., Casanueva, F. F., Finn, J. D., Forti, G., Rastrelli, G., Giwercman, A., et al. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1247-4 · Cited by 16
CSF cutoffs for MCI due to AD depend on APOEε4 carrier status
Marizzoni, M., Ferrari, C., Babiloni, C., Albani, D., Barkhof, F., Cavaliere, L., Didic, M., Forloni, G., Fusco, F., Galluzzi, S., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.12.019 · Cited by 15
McLean, J. W., Bhattrai, A., Vitali, F., Raikes, A. C., Wiegand, J. L., & Brinton, R. D. (2022) · Learning & Memory · doi:10.1101/lm.053588.122 · Cited by 15
Common occurrence of atrophic gastritis in an ageing non-hospitalised population: an autopsy study
Karhunen, P. J., Tuomisto, S., Goebeler, S., Martiskainen, M., & Kok, E. (2025) · Age and Ageing · doi:10.1093/ageing/afaf047 · Cited by 14
Self-citationNetwork dysfunction in cognitively normal APOE ε4 carriers is related to subclinical tau
Butt, O. H., Meeker, K. L., Wisch, J. K., Schindler, S. E., Fagan, A. M., Benzinger, T. L. S., Cruchaga, C., Holtzman, D. M., Morris, J. C., & Ances, B. M. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12375 · Cited by 12
Wang, H.-Y., Trocmé, C., Stucky, A., Shah, S. M., Kvasic, J., Khan, A., Morain, P., Guignot, I., Bouguen, E., Deschet, K., et al. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0280-8 · Cited by 14
Retracted
Metadata
- Authors
- Kok, E., Haikonen, S., Luoto, T., Huhtala, H., Goebeler, S., Haapasalo, H., & Karhunen, P. J.
- Affiliations
- Tampere University (FI)
- Tampere University Hospital (FI)
- Corresponding author
- Kok, Eloise
- Haikonen, Satu
- Luoto, Teemu
- Huhtala, Heini
- Goebeler, Sirkka
- Haapasalo, Hannu
- Karhunen, Pekka J.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2009-06
- Volume
- 65
- Issue
- 6
- Pages
- 650-657
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2002776021
- Cited by
- 299
- References
- 39
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 9 · 2023: 17 · 2022: 21 · 2021: 20 · 2020: 16 · 2019: 25 · 2018: 15 · 2017: 13 · 2016: 22 · 2015: 13 · 2014: 21 · 2013: 16 · 2012: 22
- FWCI
- 15.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, apolipoprotein E, APOE ε4, amyloid plaques, neurofibrillary tangles, middle age (human life stage), age-related prevalence, frontal cortex, hippocampus, sex differences, community-dwelling population, autopsy
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Apolipoproteins E, Child, Child, Preschool, Female, Genetic Carrier Screening, Humans, Infant, Infant, Newborn, Male, Middle Aged, Prospective Studies, Cohort Studies, Apolipoprotein E4, Young Adult, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review