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Exercise and Alzheimer’s disease biomarkers in cognitively normal older adults
Open accessAbstract
Objective: In addition to the increasingly recognized role of physical exercise in maintaining cognition, exercise may influence Alzheimer's disease (AD) pathology, as transgenic mouse studies show lowered levels of AD pathology in exercise groups. The objective of this study was to elucidate the association between exercise and AD pathology in humans using Pittsburgh compound‐B (PIB), amyloid‐β (Aβ) 42 , tau, and phosphorylated tau (ptau) 181 biomarkers. Methods: Sixty‐nine older adults (17 males, 52 females) aged 55 to 88 years, were recruited and confirmed to be cognitively normal. A questionnaire on physical exercise levels over the past decade was administered to all. Cerebrospinal fluid samples were collected from 56 participants, and amyloid imaging with PIB was performed on 54 participants. Results: Participants were classified based on biomarker levels. Those with elevated PIB ( p = 0.030), tau ( p = 0.040), and ptau 181 ( p = 0.044) had significantly lower exercise, with a nonsignificant trend for lower Aβ 42 ( p = 0.135) to be associated with less exercise. Results were similar for PIB after controlling for covariates; tau ( p = 0.115) and ptau 181 ( p = 0.123) differences were reduced to nonsignificant trends. Additional analyses also demonstrated that active individuals who met the exercise guidelines set by the American Heart Association had significantly lower PIB binding and higher Aβ 42 levels with and without controlling for covariates (PIB: p = 0.006 and p = 0.001; Aβ 42 : p = 0.042 and p = 0.046). Last, the associations between exercise engagement and PIB levels were more prominent in APOE epsilon 4 noncarriers. Interpretation: Collectively, these results are supportive of an association between exercise engagement and AD biomarkers in cognitively normal older adults. Ann Neurol 2010;68:311–318
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“whereas amyloid accumulation is reduced in patients who exercise regularly (Liang et al., 2010).”
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Metadata
- Authors
- Liang, K. Y., Mintun, M. A., Fagan, A. M., Goate, A. M., Bugg, J. M., Holtzman, D. M., Morris, J. C., & Head, D.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Head, Denise
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2010-08-31
- Volume
- 68
- Issue
- 3
- Pages
- 311-318
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC2936720
- OpenAlex
- W2170891630
- Cited by
- 340
- References
- 46
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 20 · 2023: 24 · 2022: 17 · 2021: 20 · 2020: 23 · 2019: 22 · 2018: 20 · 2017: 34 · 2016: 13 · 2015: 31 · 2014: 28 · 2013: 17 · 2012: 22
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH grants (P50 AG05861, P01 AG03991, P01 AG026276)
- National Institute on Aging (5T32AG00030)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- physical activity, Alzheimer's disease, Alzheimer's disease biomarkers, Pittsburgh compound B, amyloid-beta 42, tau protein, phosphorylated tau, cerebrospinal fluid, amyloid imaging, cognitively normal older adults, APOE ε4, exercise recommendations, neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Aniline Compounds, Apolipoproteins E, Female, Humans, Male, Middle Aged, Peptide Fragments, Psychiatric Status Rating Scales, Risk Factors, Thiazoles, Exercise, Geriatric Assessment, Amyloid beta-Peptides, tau Proteins, Positron-Emission Tomography
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