Cited by 340Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsPhysical Activity and Health

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Exercise and Alzheimer’s disease biomarkers in cognitively normal older adults

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Liang, Kelvin Y., Mintun, Mark A., Fagan, Anne M., Goate, Alison M., Bugg, Julie M., Holtzman, David M., Morris, John C., Head, Denise·2010·Annals of Neurology

DOI 10.1002/ana.22096PMC PMC2936720

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Abstract

Objective: In addition to the increasingly recognized role of physical exercise in maintaining cognition, exercise may influence Alzheimer's disease (AD) pathology, as transgenic mouse studies show lowered levels of AD pathology in exercise groups. The objective of this study was to elucidate the association between exercise and AD pathology in humans using Pittsburgh compound‐B (PIB), amyloid‐β (Aβ) 42 , tau, and phosphorylated tau (ptau) 181 biomarkers. Methods: Sixty‐nine older adults (17 males, 52 females) aged 55 to 88 years, were recruited and confirmed to be cognitively normal. A questionnaire on physical exercise levels over the past decade was administered to all. Cerebrospinal fluid samples were collected from 56 participants, and amyloid imaging with PIB was performed on 54 participants. Results: Participants were classified based on biomarker levels. Those with elevated PIB ( p = 0.030), tau ( p = 0.040), and ptau 181 ( p = 0.044) had significantly lower exercise, with a nonsignificant trend for lower Aβ 42 ( p = 0.135) to be associated with less exercise. Results were similar for PIB after controlling for covariates; tau ( p = 0.115) and ptau 181 ( p = 0.123) differences were reduced to nonsignificant trends. Additional analyses also demonstrated that active individuals who met the exercise guidelines set by the American Heart Association had significantly lower PIB binding and higher Aβ 42 levels with and without controlling for covariates (PIB: p = 0.006 and p = 0.001; Aβ 42 : p = 0.042 and p = 0.046). Last, the associations between exercise engagement and PIB levels were more prominent in APOE epsilon 4 noncarriers. Interpretation: Collectively, these results are supportive of an association between exercise engagement and AD biomarkers in cognitively normal older adults. Ann Neurol 2010;68:311–318

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Authors: Liang, K. Y., Mintun, M. A., Fagan, A. M., Goate, A. M., Bugg, J. M., Holtzman, D. M., Morris, J. C., & Head, D.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Head, Denise
ORCID: Fagan, Anne M.
Goate, Alison M.
Bugg, Julie M.
Holtzman, David M.
Morris, John C.
Head, Denise
Venue: Annals of Neurology
Publisher: Wiley
Published: 2010-08-31
Volume: 68
Issue: 3
Pages: 311-318
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.22096
PMC: PMC2936720
OpenAlex: W2170891630
Cited by: 340
References: 46
Citations by year: 2026: 11 · 2025: 18 · 2024: 20 · 2023: 24 · 2022: 17 · 2021: 20 · 2020: 23 · 2019: 22 · 2018: 20 · 2017: 34 · 2016: 13 · 2015: 31 · 2014: 28 · 2013: 17 · 2012: 22
FWCI: 12.90
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH grants (P50 AG05861, P01 AG03991, P01 AG026276)
National Institute on Aging (5T32AG00030)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords: physical activity, Alzheimer's disease, Alzheimer's disease biomarkers, Pittsburgh compound B, amyloid-beta 42, tau protein, phosphorylated tau, cerebrospinal fluid, amyloid imaging, cognitively normal older adults, APOE ε4, exercise recommendations, neurodegeneration
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Aniline Compounds, Apolipoproteins E, Female, Humans, Male, Middle Aged, Peptide Fragments, Psychiatric Status Rating Scales, Risk Factors, Thiazoles, Exercise, Geriatric Assessment, Amyloid beta-Peptides, tau Proteins, Positron-Emission Tomography

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Exercise and Alzheimer’s disease biomarkers in cognitively normal older adults

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