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Exercise and Alzheimer’s disease biomarkers in cognitively normal older adults
Open accessAbstract
Objective: In addition to the increasingly recognized role of physical exercise in maintaining cognition, exercise may influence Alzheimer's disease (AD) pathology, as transgenic mouse studies show lowered levels of AD pathology in exercise groups. The objective of this study was to elucidate the association between exercise and AD pathology in humans using Pittsburgh compound‐B (PIB), amyloid‐β (Aβ) 42 , tau, and phosphorylated tau (ptau) 181 biomarkers. Methods: Sixty‐nine older adults (17 males, 52 females) aged 55 to 88 years, were recruited and confirmed to be cognitively normal. A questionnaire on physical exercise levels over the past decade was administered to all. Cerebrospinal fluid samples were collected from 56 participants, and amyloid imaging with PIB was performed on 54 participants. Results: Participants were classified based on biomarker levels. Those with elevated PIB ( p = 0.030), tau ( p = 0.040), and ptau 181 ( p = 0.044) had significantly lower exercise, with a nonsignificant trend for lower Aβ 42 ( p = 0.135) to be associated with less exercise. Results were similar for PIB after controlling for covariates; tau ( p = 0.115) and ptau 181 ( p = 0.123) differences were reduced to nonsignificant trends. Additional analyses also demonstrated that active individuals who met the exercise guidelines set by the American Heart Association had significantly lower PIB binding and higher Aβ 42 levels with and without controlling for covariates (PIB: p = 0.006 and p = 0.001; Aβ 42 : p = 0.042 and p = 0.046). Last, the associations between exercise engagement and PIB levels were more prominent in APOE epsilon 4 noncarriers. Interpretation: Collectively, these results are supportive of an association between exercise engagement and AD biomarkers in cognitively normal older adults. Ann Neurol 2010;68:311–318
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“whereas amyloid accumulation is reduced in patients who exercise regularly (Liang et al., 2010).”
From The Pathobiology of Vascular Dementia (2013) · cites this paper as Liang et al., 2010
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Cites
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882
Self-citationCompendium of physical activities: an update of activity codes and MET intensities
AINSWORTH, B. E., HASKELL, W. L., WHITT, M. C., IRWIN, M. L., SWARTZ, A. M., STRATH, S. J., O???BRIEN, W. L., BASSETT, D. R., SCHMITZ, K. H., EMPLAINCOURT, P. O., et al. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200009001-00009 · Cited by 8,497
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496
Be smart, exercise your heart: Exercise effects on brain and cognition
Hillman, C. H., Erickson, K. I., & Kramer, A. F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2298 · Cited by 3,563
Physical Activity and Public Health in Older Adults
Nelson, M. E., Rejeski, W. J., Blair, S. N., Duncan, P. W., Judge, J. O., King, A. C., Macera, C. A., & Castaneda‐Sceppa, C. (2007) · Circulation · doi:10.1161/circulationaha.107.185650 · Cited by 3,057
Aerobic Exercise Training Increases Brain Volume in Aging Humans
Colcombe, S. J., Erickson, K. I., Scalf, P. E., Kim, J. S., Prakash, R., McAuley, E., Elavsky, S., Marquez, D. X., Hu, L., & Kramer, A. F. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.11.1166 · Cited by 2,134
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ 42 in humans
Fagan, A. M., Mintun, M. A., Mach, R. H., Lee, S., Dence, C. S., Shah, A. R., LaRossa, G. N., Spinner, M. L., Klunk, W. E., Mathis, C. A., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20730 · Cited by 1,246
Self-citationLeisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease
Rovio, S., Kåreholt, I., Helkala, E.-L., Viitanen, M., Winblad, B., Tuomilehto, J., Soininen, H., Nissinen, A., & Kivipelto, M. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70198-8 · Cited by 1,054
[ 11 C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease
Mintun, M. A., LaRossa, G. N., Sheline, Y. I., Dence, C. S., Lee, S. Y., Mach, R. H., Klunk, W. E., Mathis, C. A., DeKosky, S. T., & Morris, J. C. (2006) · Neurology · doi:10.1212/01.wnl.0000228230.26044.a4 · Cited by 1,036
Self-citationFagan, A. M., Roe, C. M., Xiong, C., Mintun, M. A., Morris, J. C., & Holtzman, D. M. (2007) · Archives of Neurology · doi:10.1001/archneur.64.3.noc60123 · Cited by 897
Self-citationEnvironmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
Lazarov, O., Robinson, J., Tang, Y.-P., Hairston, I. S., Korade-Mirnics, Z., Lee, V. M.-Y., Hersh, L. B., Sapolsky, R. M., Mirnics, K., & Sisodia, S. S. (2005) · Cell · doi:10.1016/j.cell.2005.01.015 · Cited by 885
APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging
Morris, J. C., Roe, C. M., Xiong, C., Fagan, A. M., Goate, A. M., Holtzman, D. M., & Mintun, M. A. (2010) · Annals of Neurology · doi:10.1002/ana.21843 · Cited by 830
Self-citationVoluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease
Adlard, P. A., Perreau, V. M., Pop, V., & Cotman, C. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0496-05.2005 · Cited by 829
Reiman, E. M., Chen, K., Liu, X., Bandy, D., Yu, M., Lee, W., Ayutyanont, N., Keppler, J., Reeder, S. A., Langbaum, J. B. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900345106 · Cited by 785
Podewils, L. J. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi092 · Cited by 675
Core candidate neurochemical and imaging biomarkers of Alzheimer's disease
Hampel, H. J., Bürger, K., Teipel, S. J., Bokde, A. L. W., Zetterberg, H., & Blennow, K. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.08.006 · Cited by 552
Morris, J. C., & Price, J. L. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:101 · Cited by 513
Self-citationOlsson, A., Vanderstichele, H., Andreasen, N., Meyer, G. D., Wallin, A., Holmberg, B., Rosengren, L., Vanmechelen, E., & Blennow, K. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2004.039347 · Cited by 431
Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.
Burns, J. M., Cronk, B. B., Anderson, H. S., Donnelly, J. E., Thomas, G. P., Harsha, A., Brooks, W. M., & Swerdlow, R. H. (2008) · Neurology · doi:10.1212/01.wnl.0000317094.86209.cb · Cited by 363
Decreased cerebrospinal fluid Aβ 42 correlates with brain atrophy in cognitively normal elderly
Fagan, A. M., Head, D., Shah, A. R., Marcus, D., Mintun, M., Morris, J. C., & Holtzman, D. M. (2009) · Annals of Neurology · doi:10.1002/ana.21559 · Cited by 327
Self-citationHULETTE, C. M., WELSH-BOHMER, K. A., MURRAY, M. G., SAUNDERS, A. M., MASH, D. C., & MCINTYRE, L. M. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199812000-00009 · Cited by 311
Storandt, M., Mintun, M. A., Head, D. M., & Morris, J. C. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.272 · Cited by 309
Self-citationWolf, S. A., Kronenberg, G., Lehmann, K., Blankenship, A., Overall, R., Staufenbiel, M., & Kempermann, G. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.004 · Cited by 288
A decade of modeling Alzheimer's disease in transgenic mice
MCGOWAN, E., ERIKSEN, J., & HUTTON, M. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.03.007 · Cited by 287
Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI
Storandt, M., Grant, E., Miller, J. P., & Morris, J. C. (2006) · Neurology · doi:10.1212/01.wnl.0000228231.26111.6e · Cited by 286
Self-citationExercise moderates age-related atrophy of the medial temporal lobe
Bugg, J. M., & Head, D. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.008 · Cited by 248
Self-citationJankowsky, J. L., Xu, G. M., Fromholt, D., Gonzales, V., & Borchelt, D. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.12.1220 · Cited by 238
Arendash, G. W., Garcia, M. F., Costa, D. A., Cracchiolo, J. R., Wefes, I., & Potter, H. (2004) · Neuroreport · doi:10.1097/01.wnr.0000137183.68847.4e · Cited by 237
Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms
Costa, D. A., Cracchiolo, J. R., Bachstetter, A. D., Hughes, T. F., Bales, K. R., Paul, S. M., Mervis, R. F., Arendash, G. W., & Potter, H. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.04.009 · Cited by 226
Cardiorespiratory Fitness and Preserved Medial Temporal Lobe Volume in Alzheimer Disease
Honea, R. A., Thomas, G., Harsha, A., Anderson, H. S., Donnelly, J. E., Brooks, W. M., & Burns, J. M. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31819cb8a2 · Cited by 217
Exercise improves cognition and hippocampal plasticity in APOE ɛ4 mice
Nichol, K., Deeny, S. P., Seif, J., Camaclang, K., & Cotman, C. W. (2009) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2009.02.006 · Cited by 213
Cho, Y. (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000052 · Cited by 198
Cracchiolo, J. R., Mori, T., Nazian, S., Tan, J., Potter, H., & Arendash, G. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.07.007 · Cited by 161
Drug development for Alzheimer's disease: where are we now and where are we headed?
Sabbagh, M. N. (2009) · The American journal of geriatric pharmacotherapy · doi:10.1016/j.amjopharm.2009.06.003 · Cited by 147
Physical activity and the maintenance of cognitive function
Rockwood, K. J., & Middleton, L. E. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.01.003 · Cited by 135
Mitchell, A. J. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.167791 · Cited by 124
Cognitive Performance in Older Women Relative to ApoE-ε4 Genotype and Aerobic Fitness
ETNIER, J. L., CASELLI, R. J., REIMAN, E. M., ALEXANDER, G. E., SIBLEY, B. A., TESSIER, D., & MCLEMORE, E. C. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000239399.85955.5e · Cited by 124
Berardi, N., Braschi, C., Capsoni, S., Cattaneo, A., & Maffei, L. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11312 · Cited by 110
Leem, Y., Lim, H., Shim, S., Cho, J., Kim, B., & Han, P. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22075 · Cited by 108
Wheel-running in a transgenic mouse model of Alzheimer's disease: Protection or symptom?
Richter, H., Ambrée, O., Lewejohann, L., Herring, A., Keyvani, K., Paulus, W., Palme, R., Touma, C., Schäbitz, W., & Sachser, N. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.005 · Cited by 107
Deeny, S. P., Poeppel, D., Zimmerman, J. B., Roth, S. M., Brandauer, J., Witkowski, S., Hearn, J. W., Ludlow, A. T., Contreras-Vidal, J. L., Brandt, J., et al. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.02.007 · Cited by 107
The impact of voluntary exercise on mental health in rodents: A neuroplasticity perspective
Pietropaolo, S., Sun, Y., Li, R., Brana, C., Feldon, J., & Yee, B. K. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.014 · Cited by 101
Construct Validity of Self-reported Historical Physical Activity
Bowles, H. R. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh209 · Cited by 100
Use of cerebrospinal fluid biomarkers in diagnosis of dementia across Europe
Hort, J., Bartoš, A., Pirttilä, T., & Scheltens, P. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02753.x · Cited by 73
Small, G. W., Siddarth, P., Burggren, A. C., Kepe, V., Ercoli, L. M., Miller, K. J., Lavretsky, H., Thompson, P. M., Cole, G. M., Huang, S. C., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.516 · Cited by 58
Research works printed but not linked: 1
- 2008, Guideline for Alzheimer's disease management
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Dubois, B., Hampel, H., Feldman, H. H., Scheltens, P., Aisen, P., Andrieu, S., Bakardjian, H., Benali, H., Bertram, L., Blennow, K., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.002 · Cited by 1,925
Self-citationThe Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857
Alzheimer’s Disease: The Challenge of the Second Century
Holtzman, D. M., Morris, J. C., & Goate, A. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002369 · Cited by 1,424
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Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030
Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging
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Metadata
- Authors
- Liang, K. Y., Mintun, M. A., Fagan, A. M., Goate, A. M., Bugg, J. M., Holtzman, D. M., Morris, J. C., & Head, D.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Head, Denise
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2010-08-31
- Volume
- 68
- Issue
- 3
- Pages
- 311-318
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC2936720
- OpenAlex
- W2170891630
- Cited by
- 340
- References
- 46
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 20 · 2023: 24 · 2022: 17 · 2021: 20 · 2020: 23 · 2019: 22 · 2018: 20 · 2017: 34 · 2016: 13 · 2015: 31 · 2014: 28 · 2013: 17 · 2012: 22
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH grants (P50 AG05861, P01 AG03991, P01 AG026276)
- National Institute on Aging (5T32AG00030)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- physical activity, Alzheimer's disease, Alzheimer's disease biomarkers, Pittsburgh compound B, amyloid-beta 42, tau protein, phosphorylated tau, cerebrospinal fluid, amyloid imaging, cognitively normal older adults, APOE ε4, exercise recommendations, neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Aniline Compounds, Apolipoproteins E, Female, Humans, Male, Middle Aged, Peptide Fragments, Psychiatric Status Rating Scales, Risk Factors, Thiazoles, Exercise, Geriatric Assessment, Amyloid beta-Peptides, tau Proteins, Positron-Emission Tomography
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