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Cited by 754

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

The blood–brain barrier in health and disease

Daneman, Richard·2012·Annals of Neurology
DOI 10.1002/ana.23648
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Abstract

The blood–brain barrier (BBB) is a term used to describe a series of properties possessed by the vasculature of the central nervous system (CNS) that tightly regulate the movement of ions, molecules, and cells between the blood and the CNS. This barrier is crucial to provide the appropriate environment to allow for proper neural function, as well as protect the CNS from injury and disease. In this review, I discuss the cellular and molecular composition of the BBB and how the development and function of the BBB is regulated by interactions with the CNS microenvironment. I further discuss what is known about BBB dysfunction during CNS injury and disease, as well as methodology used to deliver drugs across the BBB to the CNS. ANN NEUROL 2012;72:648–672

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Metadata

Authors
Daneman, R.
Venue
Annals of Neurology
Publisher
Wiley
Published
2012-11
Volume
72
Issue
5
Pages
648-672
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.23648
OpenAlex
W2167739272
Cited by
754
References
40
FWCI
14.78
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The blood–brain barrier in health and disease. https://app.cochat.ai/papers/10.1002/ana.23648
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Daneman, R. (2012). The blood–brain barrier in health and disease. Annals of Neurology. https://doi.org/10.1002/ana.23648

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.