Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
Abstract
A crucial question in the study of immunological reactions in the central nervous system (CNS) concerns the identity of the parenchymal cells that function as the antigen-presenting cells in that organ. Rat bone marrow chimeras and encephalitogenic, major histocompatability-restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived. In addition, these perivascular cells are fully competent to present antigen to lymphocytes in an appropriately restricted manner. These findings are important for bone marrow transplantation and for neuroimmunological diseases such as multiple sclerosis.
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The positive results of HSC transplantation into cALD patients indicated a role for brain microglia because microglia were thought to originate in bone marrow at that time.
“The positive results of HSC transplantation into cALD patients [24,356] indicated a role for brain microglia because microglia were thought to originate in bone marrow at that time [357].”
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Peripheral macrophages in the CNS of healthy mice show an activated CD45hi MHC class IIhi phenotype.
“Peripheral macrophages in the CNS of healthy mice showed an activated CD45hiMHC class IIhi phenotype, which was consistent with previous studies25.”
From MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway (2011) · cites this paper as [25]
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- Authors
- Hickey, W. F., & Kimura, H.
- Affiliations
- University of Pennsylvania (US)
- ORCID
- Hickey, William F.
- Venue
- Science
- Published
- 1988-01-15
- Volume
- 239
- Issue
- 4837
- Pages
- 290-292
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076407459
- Cited by
- 1,466
- References
- 32
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 21 · 2023: 13 · 2022: 26 · 2021: 15 · 2020: 19 · 2019: 30 · 2018: 26 · 2017: 33 · 2016: 30 · 2015: 34 · 2014: 32 · 2013: 34 · 2012: 48
- FWCI
- 37.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (KO7-NS0087)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- antigen presentation, bone marrow chimeras, bone marrow-derived cells, encephalitogenic T cells, multiple sclerosis, neuroimmunology, bone marrow transplantation
- MeSH terms
- Animals, Antigen-Presenting Cells, Astrocytes, Bone Marrow, Central Nervous System, Chimera, Encephalomyelitis, Autoimmune, Experimental, Endothelium, Graft vs Host Disease, Histocompatibility Antigens, Immunohistochemistry, Multiple Sclerosis, Neuroglia, Rats, Inbred Lew, T-Lymphocytes, Bone Marrow Transplantation, Rats
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