Cited by 193Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

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Effect of lifestyle activities on alzheimer disease biomarkers and cognition

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Vemuri, Prashanthi, Lesnick, Timothy G., Przybelski, Scott A., Knopman, David S., Roberts, Rosebud O., Lowe, Val J., Kantarci, Kejal, Senjem, Mathew L., Gunter, Jeffrey L., Boeve, Bradley F., Petersen, Ronald C., Jack, Clifford R.·2012·Annals of Neurology

DOI 10.1002/ana.23665PMC PMC3539211

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Abstract

Objective: A study was undertaken to investigate the association of intellectual and physical activity with biomarkers of Alzheimer disease (AD) pathophysiology and cognition in a nondemented elderly population. The biomarkers evaluated were brain Aβ load via Pittsburgh compound B (PiB)‐positron emission tomography (PET), neuronal dysfunction via 18 F‐fluorodeoxyglucose (FDG)‐PET, and neurodegeneration via structural magnetic resonance imaging (MRI). Methods: We studied 515 nondemented (428 cognitively normal and 87 mild cognitive impairment) participants in the population‐based Mayo Clinic Study of Aging who completed a 3T MRI, PET scans, and APOE genotype, and had lifestyle activity measures and cognition data available. The imaging measures computed were global PiB‐PET uptake, and global FDG‐PET and MRI based hippocampal volume. We consolidated activity variables into lifetime intellectual, current intellectual, and current physical activities. We used a global cognitive z score as a measure of cognition. We applied 2 independent methods—partial correlation analysis adjusted for age and gender and path analysis using structural equations—to evaluate the associations between lifestyle activities, imaging biomarkers, and global cognition. Results: None of the lifestyle variables were correlated with the biomarkers, and the path associations between lifestyle variables and biomarkers were not significant (p > 0.05). Conversely, all the biomarkers were correlated with global cognitive z score (p < 0.05), and the path associations between (lifetime and current) intellectual activities and global z score were significant (p < 0.01). Interpretation: Intellectual and physical activity lifestyle factors were not associated with AD biomarkers, but intellectual lifestyle factors explained variability in the cognitive performance in this nondemented population. This study provides evidence that lifestyle activities may delay the onset of dementia but do not significantly influence the expression of AD pathophysiology. ANN NEUROL 2012;72:730–738

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Society Interacting with Brain, Cognition, and Health in Late Life
Chey, J. (2023) · Cambridge University Press eBooks · doi:10.1017/9781108974325.008
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dos Santos, G. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.100.2023.tde-07122023-084641
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Additional file 1 of Associations of healthy lifestyles with cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact older adults: the CABLE study
Hou, X.-H., Xu, W., Bi, Y.-L., Shen, X.-N., Ma, Y.-H., Dong, Q., Tan, L., & Yu, J. (2021) · Figshare · doi:10.6084/m9.figshare.14450743
Additional file 8 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
Grasset, L., Proust-Lima, C., Mangin, J.-F., Habert, M.-O., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793151
Additional file 3 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
Grasset, L., Proust-Lima, C., Mangin, J.-F., Habert, M.-O., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793133
Additional file 2 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
Grasset, L., Proust-Lima, C., Mangin, J.-F., Habert, M.-O., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793130
Additional file 6 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
Grasset, L., Proust-Lima, C., Mangin, J.-F., Habert, M.-O., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793145
Additional file 5 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
Grasset, L., Proust-Lima, C., Mangin, J.-F., Habert, M.-O., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793139
Additional file 4 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
Grasset, L., Proust-Lima, C., Mangin, J.-F., Habert, M.-O., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793136
Additional file 1 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
Grasset, L., Proust-Lima, C., Mangin, J.-F., Habert, M.-O., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793127
Additional file 9 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
Grasset, L., Proust-Lima, C., Mangin, J.-F., Habert, M.-O., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793154
Additional file 7 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
Grasset, L., Proust-Lima, C., Mangin, J.-F., Habert, M.-O., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793148
Investigating the effects of post-exercise serum treatments on APP processing in iPSC-derived neurons and astrocytes
Elsworthy, R. J., Spencer, F. S. E., Allen, S., Dunleavy, C., Whitham, M., Lucas, S. J. E., Hill, E. J., & Aldred, S. (2026) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2026.106920
Language and color perception : the case of the Italian and French blue semantics : a contrastive analysis of linguistic categorizations and cognitive functions in monolingual and bilingual speakers
Simoncelli, C. (2022) · theses.fr (ABES) · doi:10.70675/4ec327fbz873ez48c1z9dc9z3faada1a9694
Multidimensional Analysis of Physical, Psychosocial, and Cognitive Impairment in People with Chronic Neck Pain
Güven, Z., Arsava, E. Y., Işıkay, A. İ., Akyay, A., Karabulut, E., & Uysal, S. A. (2026) · Medicina · doi:10.3390/medicina62050956
Brain structure in the cingulate cortex and locus coeruleus in late life is associated with engagement in complex mental activities across the life span
Crawford, J. L., Chen, H.-Y., Adornato, A. A., Matulonis, J., Hooker, J. M., Jacobs, H. I. L., & Berry, A. S. (2026) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2026.06.012

Authors: Vemuri, P., Lesnick, T. G., Przybelski, S. A., Knopman, D. S., Roberts, R. O., Lowe, V. J., Kantarci, K., Senjem, M. L., Gunter, J. L., Boeve, B. F., Petersen, R. C., & Jack, C. R.
Affiliations: Mayo Clinic (US)
Corresponding author: Vemuri, Prashanthi
ORCID: Vemuri, Prashanthi
Lesnick, Timothy G.
Przybelski, Scott A.
Knopman, David S.
Lowe, Val J.
Kantarci, Kejal
Gunter, Jeffrey L.
Boeve, Bradley F.
Petersen, Ronald C.
Jack, Clifford R.
Venue: Annals of Neurology
Publisher: Wiley
Published: 2012-11
Volume: 72
Issue: 5
Pages: 730-738
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.23665
PMC: PMC3539211
OpenAlex: W1974934145
Cited by: 193
References: 42
Citations by year: 2026: 3 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 26 · 2021: 11 · 2020: 11 · 2019: 21 · 2018: 14 · 2017: 16 · 2016: 16 · 2015: 22 · 2014: 21 · 2013: 5
FWCI: 10.97
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 56 d)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG11378, P50‐AG16574, U01AG06786, K99 AG37573, U01AG006786, K99AG037573, R01AG011378, R01AG041851, P50AG016574)
National Center for Research Resources (C06RR018898)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords: Alzheimer's disease, lifestyle habits, intellectual activity, physical activity, cognitive function, amyloid-beta, Pittsburgh compound B PET, FDG-PET, hippocampal volume, neurodegeneration, mild cognitive impairment, non-demented elderly, APOE genotype, Mayo Clinic Study of Aging
MeSH terms: Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cognition Disorders, Female, Humans, Life Style, Magnetic Resonance Imaging, Male, Models, Biological, Motor Activity, Neuropsychological Tests, Surveys and Questionnaires, Sex Factors, Statistics as Topic, Amyloid beta-Peptides, Principal Component Analysis, Positron-Emission Tomography

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