Much of late life cognitive decline is not due to common neurodegenerative pathologies

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Items 101–200 of 322

1. Perspective Insights into Disease Progression, Diagnostics, and Therapeutic Approaches in Alzheimer's Disease: A Judicious Update
   Arif Tasleem Jan, Mudsser Azam, Safikur Rahman, Angham M. S. Almigeiti, Duk Hwan Choi, Eun Ju Lee, Qazi Mohd Rizwanul Haq, Inho Choi · 2017 · Frontiers in Aging Neuroscience
2. Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample
   Alfredo Ramos‐Miguel, Christa Hercher, Clare L. Beasley, Alasdair M. Barr, Thomas A. Bayer, Peter Falkai, Sue E. Leurgans, Julie A. Schneider, David Alan Bennett, William G. Honer · 2015 · Molecular Neurodegeneration
3. Mixed neuropathologies and associations with domain-specific cognitive decline
   Willa D. Brenowitz, Rebecca A. Hubbard, Christopher Dirk Keene, Stephen E. Hawes, W. T. Longstreth, Randy L Woltjer, Walter A. Kukull · 2017 · Neurology
4. The aging immune system in Alzheimer’s and Parkinson’s diseases
   Kelsey S. Heavener, Elizabeth M. Bradshaw · 2022 · Seminars in Immunopathology
5. Deconstructing and targeting the genomic architecture of human neurodegeneration
   Philip L. De Jager, Hyun‐Sik Yang, David Alan Bennett · 2018 · Nature Neuroscience
6. LDL cholesterol is associated with higher AD neuropathology burden independent of APOE
   Aliza P. Wingo, Selina Vattathil, Jiaqi Liu, Wen Fan, David J. Cutler, Allan I. Levey, Julie A. Schneider, David Alan Bennett, Thomas S. Wingo · 2022 · Journal of Neurology Neurosurgery & Psychiatry
7. Severe hyposmia distinguishes neuropathologically confirmed dementia with Lewy bodies from Alzheimer’s disease dementia
   Thomas G. Beach, Charles H. Adler, Nan Zhang, Geidy E. Serrano, Lucia I. Sue, Erika D. Driver‐Dunckley, Shyamal H. Mehta, E Zamrini, Marwan Noel Sabbagh, Holly A. Shill et al. · 2020 · PLoS ONE
8. Hippocampal Neurodegenerative Pathology in Post-stroke Dementia Compared to Other Dementias and Aging Controls
   Rufus Akinyemi, Louise M. Allan, Arthur Ernest Oakley, Raj N. Kalaria · 2017 · Frontiers in Neuroscience
9. Age and the association of dementia-related pathology with trajectories of cognitive decline
   Willemijn J. Jansen, Robert S. Wilson, Pieter Jelle Visser, Sukriti Nag, Julie A. Schneider, Bryan David James, Sue E. Leurgans, Ana Werneck Capuano, David Alan Bennett, Patricia A. Boyle · 2017 · Neurobiology of Aging
10. Risk of incident clinical diagnosis of Alzheimer's disease–type dementia attributable to pathology‐confirmed vascular disease
    Hiroko Hayama Dodge, Jian Ying Zhu, Randy L Woltjer, Peter T. Nelson, David Alan Bennett, Nigel J. Cairns, David W. Fardo, Jeffrey Alan Kaye, Deniz Erten‐Lyons, Nora Mattek et al. · 2016 · Alzheimer s & Dementia
11. Multi-cellular communities are perturbed in the aging human brain and Alzheimer’s disease
    Cain, Anael, Taga, Mariko, McCabe, Cristin, Green, Gilad, Hekselman, Idan, White, Charles C., Lee, Dylan I., Gaur, Pallavi, Rozenblatt-Rosen, Orit, Zhang, Feng et al. · 2020
12. Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer’s disease
    Alfredo Ramos‐Miguel, Ken Sawada, Andrea A. Jones, Allen E. Thornton, Alasdair M. Barr, Sue E. Leurgans, Julie A. Schneider, David Alan Bennett, William G. Honer · 2016 · Acta Neuropathologica
13. MRI assessment of whole-brain structural changes in aging
    Guo, Hui, Siu, William, D’Arcy, Ryan, Black, Sandra, Grajauskas, Lukas, Singh, Sonia, Zhang, Yunting, Rockwood, Kenneth, Song, Xiaowei · 2017 · Clinical Interventions in Aging
14. Cognitively stimulating environments and cognitive reserve: the case of personal social networks
    Siyun Peng, Adam R. Roth, Liana G. Apostolova, Andrew J. Saykin, Brea Louise Perry · 2022 · Neurobiology of Aging
15. How Does Psychosocial Behavior Contribute to Cognitive Health in Old Age?
    Robert Wilson, David Alan Bennett · 2017 · Brain Sciences
16. The Vascular-Immune Hypothesis of Alzheimer’s Disease
    Rashi I. Mehta, Rupal I. Mehta · 2023 · Biomedicines
17. Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease
    Robert A. Sweet, Matthew L. MacDonald, Caitlin M. Kirkwood, Ying Ding, Tadhg A. Schempf, Jackie Jones-Laughner, Julia Kofler, Miloš D. Ikonomović, Oscar L. López, Megan E. Garver et al. · 2016 · Molecular & Cellular Proteomics
18. Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age
    Alfredo Ramos‐Miguel, Andrea A. Jones, Ken Sawada, Alasdair M. Barr, Thomas A. Bayer, Peter Falkai, Sue E. Leurgans, Julie A. Schneider, David Alan Bennett, William G. Honer · 2018 · Neurobiology of Disease
19. Longitudinal Associations Between Loneliness and Cognitive Ability in the Lothian Birth Cohort 1936
    Okely, Judith A, Deary, Ian J · 2019 · The Journals of Gerontology: Series B
20. Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies
    Jingyun Yang, Lei Yu, Chris Gaiteri, Gyan Prakash Srivastava, Lori Beth Chibnik, Sue E. Leurgans, Julie A. Schneider, Alexander Meissner, Philip L. De Jager, David Alan Bennett · 2015 · The International Journal of Biochemistry & Cell Biology
21. Multi-omic integration via similarity network fusion to detect molecular subtypes of ageing
    Yang, Mu, Matan-Lithwick, Stuart, Wang, Yanling, De Jager, Philip L, Bennett, David A, Felsky, Daniel · 2023 · Brain Communications
22. Brain pathology is related to total daily physical activity in older adults
    Aron S. Buchman, Robert J. Dawe, Lei Yu, Andrew S. P. Lim, Robert S. Wilson, Julie A. Schneider, David Alan Bennett · 2018 · Neurology
23. Contributions of loneliness to cognitive impairment and dementia in older adults are independent of other risk factors and Alzheimer’s pathology: a narrative review
    Barry Oken, Josh Kaplan, Daniel Klee, Autumn M. Gallegos · 2024 · Frontiers in Human Neuroscience
24. Person-Specific Contributions of Brain Pathologies to Progressive Parkinsonism in Older Adults
    Aron S. Buchman, Lei Yu, Shahram Oveisgharan, José M. Farfel, Julie A. Schneider, David Alan Bennett · 2020 · The Journals of Gerontology Series A
25. A History of Senile Plaques: From Alzheimer to Amyloid Imaging
    Thomas G. Beach · 2022 · Journal of Neuropathology & Experimental Neurology
26. Association between liver fibrosis and incident dementia in the UK Biobank study
    Neal S. Parikh, Hooman Kamel, Cenai Zhang, Sonal Rajesh Kumar, Russell Evan Rosenblatt, Pascal Spincemaille, Ajay Kumar Gupta, David E. Cohen, Mony J. de Leon, Rebecca F. Gottesman et al. · 2022 · European Journal of Neurology
27. Controversial Past, Splendid Present, Unpredictable Future: A Brief Review of Alzheimer Disease History
    Félix Bermejo‐Pareja, Teodoro del Ser · 2024 · Journal of Clinical Medicine
28. Temporal course of neurodegenerative effects on cognition in old age.
    Robert S. Wilson, Ana Werneck Capuano, David Bennett, Julie A. Schneider, Patricia A. Boyle · 2016 · Neuropsychology
29. Exercise improves cognitive function in aging patients.
    Jianping Hu, Yan-Hua Guo, Feng Wang, Xinping C. Zhao, Quanhai Zhang, Qing-Hua Song · 2014 · PubMed Central
30. Coupled changes in hippocampal structure and cognitive ability in later life
    Devasuda Anblagan, María Valdés Hernández, Stuart James Ritchie, Benjamin S. Aribisala, Natalie A. Royle, Iona F. Hamilton, Simon R. Cox, Alan J. Gow, Alison Pattie, Janie Corley et al. · 2018 · Brain and Behavior
31. Frailty and neuropathology in relation to dementia status: the Cambridge City over-75s Cohort study
    Lindsay M. K. Wallace, Sally Hunter, Olga Theou, Jane Fleming, Kenneth J. Rockwood, Carol Brayne · 2021 · International Psychogeriatrics
32. Three midlife strategies to prevent cognitive impairment due to Alzheimer's disease
    Victor W. Henderson · 2014 · Climacteric
33. Evaluating Alzheimer's disease biomarkers as mediators of age-related cognitive decline
    Timothy J. Hohman, Douglas Tommet, Shawn M. Marks, Joey Annette Contreras, Richard Norman Jones, Dan Mungas · 2017 · Neurobiology of Aging
34. Particulate Matter in Human Elderly: Higher Susceptibility to Cognitive Decline and Age-Related Diseases
    Caridad López-Granero, Leona Polyanskaya, Diego Ruiz‐Sobremazas, Ángel Barrasa, Michael Aschner, Matilde Alique · 2023 · Biomolecules
35. A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies
    Patrick, Ellis, Olah, Marta, Taga, Mariko, Klein, Hans-Ulrich, Xu, Jishu, White, Charles C., Felsky, Daniel, Agrawal, Sonal, Gaiteri, Chris, Chibnik, Lori B. et al. · 2021 · Translational Psychiatry
36. Psychological and neurobiological mechanisms involved in the relationship between loneliness and cognitive decline in older adults
    Sanaz Dabiri, Denée T. Mwendwa, Alfonso L. Campbell · 2023 · Brain Behavior and Immunity
37. Neuropathologic features of TOMM40 '523 variant on late‐life cognitive decline
    Lei Yu, Michael William Lutz, José M. Farfel, Robert Smith Wilson, Daniel K. Burns, Ann M. Saunders, Philip L. De Jager, Lisa Laverne Barnes, Julie A. Schneider, David Alan Bennett · 2017 · Alzheimer s & Dementia
38. Predictive blood biomarkers and brain changes associated with age-related cognitive decline
    Tyler Seyhan Saunders, Francesca E Pozzolo, Amanda Heslegrave, Declan King, Robert I. McGeachan, Maxwell P Spires-Jones, Sarah E. Harris, Craig William Ritchie, Graciela Muniz Terrera, Ian J. Deary et al. · 2023 · Brain Communications
39. Interactive Effect of APOE Genotype and Blood Pressure on Cognitive Decline: The PATH Through Life Study
    Shea J. Andrews, Debjani Das, Kaarin Jane Anstey, Simon Easteal · 2015 · Journal of Alzheimer s Disease
40. Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline
    Lei Yu, Robert J. Dawe, Patricia A. Boyle, Chris Gaiteri, Jingyun Yang, Aron S. Buchman, Julie A. Schneider, Konstantinos Arfanakis, Philip L. De Jager, David Alan Bennett · 2017 · JAMA Neurology
41. The structural–functional-connectivity coupling of the aging brain
    Hui Zhang, Peng Cao, Henry Ka‐Fung Mak, Edward Sai Kam Hui · 2024 · GeroScience
42. Brain microRNAs are associated with variation in cognitive trajectory in advanced age
    Aliza P. Wingo, Mengli Wang, Jiaqi Liu, Michael S. Breen, Hyun‐Sik Yang, Beisha Tang, Julie A. Schneider, Nicholas T. Seyfried, James J. Lah, Allan I. Levey et al. · 2022 · Translational Psychiatry
43. Lack of Benefit With Idalopirdine for Alzheimer Disease
    David Alan Bennett · 2018 · JAMA
44. Insights into the pathological basis of dementia from population‐based neuropathology studies
    Stephen B. Wharton, Julie E. Simpson, Paul G. Ince, Connor Duncan Richardson, Richard L. Merrick, Fiona E. Matthews, Carol Brayne, CFAS · 2023 · Neuropathology and Applied Neurobiology
45. The interplay between age at menopause and synaptic integrity on Alzheimer’s disease risk in women
    Madeline Wood Alexander, William G. Honer, Rowan Saloner, Liisa A.M. Galea, David Alan Bennett, Jennifer S. Rabin, Kaitlin Blackstone Casaletto · 2025 · Science Advances
46. Postmortem MRI: a novel window into the neurobiology of late life cognitive decline
    Robert J. Dawe, Lei Yu, Sue E. Leurgans, Julie A. Schneider, Aron S. Buchman, Konstantinos Arfanakis, David Alan Bennett, Patricia A. Boyle · 2016 · Neurobiology of Aging
47. Common age‐related neuropathologies and yearly variability in cognition
    Lei Yu, Tianhao Wang, Robert Smith Wilson, Sue E. Leurgans, Julie A. Schneider, David Alan Bennett, Patricia A. Boyle · 2019 · Annals of Clinical and Translational Neurology
48. Beneficial association of angiotensin-converting enzyme inhibitors and statins on the occurrence of possible Alzheimer’s disease after traumatic brain injury
    Mingfei Li, Joel I. Reisman, Benjamin Morris-Eppolito, Shirley X. Qian, Lewis E. Kazis, Benjamin L. Wolozin, Lee E. Goldstein, Weiming Xia · 2020 · Alzheimer s Research & Therapy
49. Trends in the public health significance, definitions of disease, and implications for prevention of Alzheimer’s disease
    Carol A. Derby · 2020 · Current Epidemiology Reports
50. Novel Biomarkers of Alzheimer's Disease: Based Upon N-methyl-D-aspartate Receptor Hypoactivation and Oxidative Stress
    Ting-I Chiang, Yi‐Hsiang Yu, Chieh‐Hsin Lin, Hsien‐Yuan Lane · 2021 · Clinical Psychopharmacology and Neuroscience
51. Multi-omic Directed Networks Describe Features of Gene Regulation in Aged Brains and Expand the Set of Genes Driving Cognitive Decline
    Shinya Tasaki, Chris Gaiteri, Sara Mostafavi, Lei Yu, Yanling Wang, Philip L. De Jager, David Alan Bennett · 2018 · Frontiers in Genetics
52. The synaptic pathology of cognitive life
    William G. Honer, Alfredo Ramos‐Miguel, Jehan Alamri, Ken Sawada, Alasdair M. Barr, Julie A. Schneider, David Alan Bennett · 2019 · Dialogues in Clinical Neuroscience
53. Association between liver fibrosis and cognition in a nationally representative sample of older adults
    Neal S. Parikh, Sonal Rajesh Kumar, Russell Evan Rosenblatt, Chen Zhao, David E. Cohen, Costantino Iadecola, Hooman Kamel · 2020 · European Journal of Neurology
54. Quantifying cognitive resilience in Alzheimer’s Disease: The Alzheimer’s Disease Cognitive Resilience Score
    Tianyi Yao, Elizabeth M. Sweeney, John Nagorski, Joshua M Shulman, Genevera I. Allen · 2020 · PLoS ONE
55. Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample
    Alfredo Ramos‐Miguel, Jesús A. Garcı́a-Sevilla, Alasdair M. Barr, Thomas A. Bayer, Peter Falkai, Sue E. Leurgans, Julie A. Schneider, David Alan Bennett, William G. Honer, María Julia García-Fuster · 2017 · Molecular Neurodegeneration
56. Late Onset Alzheimer’s Disease Risk Variants in Cognitive Decline: The PATH Through Life Study
    Shea J. Andrews, Debjani Das, Kaarin Jane Anstey, Simon Easteal · 2017 · Journal of Alzheimer s Disease
57. Hospitalization, Alzheimer's Disease and Related Neuropathologies, and Cognitive Decline
    Bryan David James, Robert S. Wilson, Ana Werneck Capuano, Patricia A. Boyle, Raj C. Shah, Melissa Lamar, Eugene Wesley Ely, David Alan Bennett, Julie A. Schneider · 2019 · Annals of Neurology
58. The “cognitive clock”: A novel indicator of brain health
    Patricia A. Boyle, Tianhao Wang, Lei Yu, Robert Smith Wilson, Robert J. Dawe, Konstantinos Arfanakis, Julie A. Schneider, Todd L. Beck, Kumar Bharat Rajan, Denis A. Evans et al. · 2021 · Alzheimer s & Dementia
59. Genetic risk for Alzheimer’s dementia predicts motor deficits through multi-omic systems in older adults
    Shinya Tasaki, Chris Gaiteri, Vladislav Petyuk, Katherine D. Blizinsky, Philip L. De Jager, Aron S. Buchman, David Alan Bennett · 2019 · Translational Psychiatry
60. Proportion of cognitive loss attributable to terminal decline
    Robert S. Wilson, Lei Yu, Sue E. Leurgans, David Alan Bennett, Patricia A. Boyle · 2019 · Neurology
61. Combination Therapy in Alzheimer’s Disease: Is It Time?
    Arash Salehipour, Motahareh Bagheri, Mohammadmahdi Sabahi, Mahsa Dolatshahi, Delphine Boche · 2022 · Journal of Alzheimer s Disease
62. Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation
    Anthony D. Ramnauth, Madhavi Tippani, Heena R. Divecha, Alexis R. Papariello, Ryan A. Miller, Erik D. Nelson, Jacqueline R. Thompson, Elizabeth A. Pattie, J. Kleinman, Kristen R. Maynard et al. · 2025 · Cell Reports
63. Early- vs late-onset subcortical vascular cognitive impairment
    Young Kyoung Jang, Hunki Kwon, Yeo Jin Kim, Na‐Yeon Jung, Jin San Lee, Juyoun Lee, Juhee Chin, Kiho Im, Seun Jeon, Jong Min Lee et al. · 2016 · Neurology
64. Cognitive aging and experience of playing a musical instrument.
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65. Neurocognitive sequela of burn injury in the elderly
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66. Apolipoprotein E, cognitive function, and cognitive decline among older Taiwanese adults
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67. Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer’s disease: a longitudinal cohort study
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68. Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline
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69. Framingham General Cardiovascular Risk Score and Cognitive Impairment
    Costantino Iadecola, Neal S. Parikh · 2020 · Journal of the American College of Cardiology
70. The Relationship between Amyloid Deposition, Neurodegeneration, and Cognitive Decline in Dementia
    Rik R. Vandenberghe · 2014 · Current Neurology and Neuroscience Reports
71. THE EFFECT OF VASCULAR NEUROPATHOLOGY ON LATE-LIFE COGNITION: RESULTS FROM THE SMART PROJECT
    Richard J. Kryscio, Erin L. Abner, Peter T. Nelson, David Alan Bennett, J. Schneider, Lei Yu, Laura S. Hemmy, Kelvin O. Lim, Kamal Masaki, Nigel J. Cairns et al. · 2016 · The Journal of Prevention of Alzheimer s Disease
72. Nanomedicine against Alzheimer’s and Parkinson’s Disease
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73. The Key Factors Predicting Dementia in Individuals With Alzheimer’s Disease-Type Pathology
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74. Toward MRI ‐based whole‐brain health assessment: The brain atrophy and lesion index ( BALI )
    Lukas A. Grajauskas, Hui Guo, Ryan C.N. D’Arcy, Xiaowei Song · 2018 · Aging Medicine
75. Postmortem brain MRI is related to cognitive decline, independent of cerebral vessel disease in older adults
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76. Association of chronic liver disease with cognition and brain volumes in two randomized controlled trial populations
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77. Associations of VGF with Neuropathologies and Cognitive Health in Older Adults
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78. Plasma proteomic associations with Alzheimer’s disease endophenotypes
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79. Explainable deep learning approach for extracting cognitive features from hand-drawn images of intersecting pentagons
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80. Interrogation of the human cortical peptidome uncovers cell-type specific signatures of cognitive resilience against Alzheimer’s disease
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81. Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults
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82. Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models
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83. Disturbed Sleep in Preclinical Cognitive Impairment: Cause and Effect?
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84. Cognitive Change at the End of Life in Nursing Home Residents: Differential Trajectories of Terminal Decline
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85. Exosomes in Age-Related Cognitive Decline: Mechanistic Insights and Improving Outcomes
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86. Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias
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87. Predictors of cognitive functioning trajectories among older Americans: A new investigation covering 20 years of age- and non-age-related cognitive change
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88. The influence of age and approaching death on the course of nondopaminergic symptoms in Parkinson's disease
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89. Prediction of neuropathologic lesions from clinical data
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90. Reduce vascular risk to prevent dementia?
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91. A Workshop on Cognitive Aging and Impairment in the 9/11-Exposed Population
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92. Associations Between Loneliness and Cognitive Resilience to Neuropathology in Older Adults
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93. Cerebrovascular markers of WMH and infarcts in ADNI: A historical perspective and future directions
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94. Blood DNA methylation signature for incident dementia: Evidence from longitudinal cohorts
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95. Longitudinal Modeling of Depressive Trajectories Among HIV-Infected Men Using Cocaine
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96. Genetic risk for Alzheimer’s disease influences neuropathology via multiple biological pathways
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97. Association of Stroke and Cerebrovascular Pathologies With Scam Susceptibility in Older Adults
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98. Inflammation and Cognition in Older Adults: Evidence from Taiwan
    Megan A. Todd · 2017 · Biodemography and Social Biology
99. Tripartite Relationship Among Synaptic, Amyloid, and Tau Proteins
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100. Physical activity, brain tissue microstructure, and cognition in older adults
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