Much of late life cognitive decline is not due to common neurodegenerative pathologies
Open accessAbstract
Objective: The pathologic indices of Alzheimer disease, cerebrovascular disease, and Lewy body disease accumulate in the brains of older persons with and without dementia, but the extent to which they account for late life cognitive decline remains unknown. We tested the hypothesis that these pathologic indices account for the majority of late life cognitive decline. Methods: A total of 856 deceased participants from 2 longitudinal clinical–pathologic studies, Rush Memory and Aging Project and Religious Orders Study, completed a mean of 7.5 annual evaluations, including 17 cognitive tests. Neuropathologic examinations provided quantitative measures of global Alzheimer pathology, amyloid load, tangle density, macroscopic infarcts, microinfarcts, and neocortical Lewy bodies. Random coefficient models were used to examine the linear relation of pathologic indices with global cognitive decline. In subsequent analyses, random change point models were used to examine the relation of the pathologic indices with the onset of terminal decline and rates of preterminal and terminal decline (ie, nonlinear decline). Results: Cognition declined a mean of about 0.11U per year (estimate = −0.109, standard error [SE] = 0.004, p < 0.001), with significant individual differences in rates of decline; the variance estimate for the individual slopes was 0.013 (SE = 0.112, p < 0.001). In separate analyses, global Alzheimer pathology, amyloid, tangles, macroscopic infarcts, and neocortical Lewy bodies were associated with faster rates of decline and explained 22%, 6%, 34%, 2%, and 8% of the variation in decline, respectively. When analyzed simultaneously, the pathologic indices accounted for a total of 41% of the variation in decline, and the majority remained unexplained. Furthermore, in random change point models examining the influence of the pathologic indices on the onset of terminal decline and the preterminal and terminal components of the cognitive trajectory, the common pathologic indices accounted for less than a third of the variation in the onset of terminal decline and rates of preterminal and terminal decline. Interpretation: The pathologic indices of the common causes of dementia are important determinants of cognitive decline in old age and account for a large proportion of the variation in late life cognitive decline. Surprisingly, however, much of the variation in cognitive decline remains unexplained, suggesting that other important determinants of cognitive decline remain to be identified. Identification of the mechanisms that contribute to the large unexplained proportion of cognitive decline is urgently needed to prevent late life cognitive decline. Ann Neurol 2013;74:478–489
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pathologies such as β-amyloid plaques, neurofibrillary tangles, microinfarct, macroinfarct, and Lewy bodies together capture only about 41% of the variance in cognitive trajectory, leaving 59% unexplained.
“However, pathologies such as β-amyloid plaques, neurofibrillary tangles, microinfarct, macroinfarct, and Lewy bodies together capture only about 41% of the variance in cognitive trajectory, leaving 59% unexplained5,7.”
From Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age (2019) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Gelman, A., Carlin, J. B., Stern, H. S., Dunson, D. B., Vehtari, A., & Rubin, D. B. (2013) · doi:10.1201/b16018 · Cited by 27,276 · see citing works
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923 · see citing works
WinBUGS - A Bayesian modelling framework: Concepts, structure, and extensibility
Lunn, D. J., Thomas, A., Best, N., & Spiegelhalter, D. J. (2000) · Statistics and Computing · doi:10.1023/a:1008929526011 · Cited by 5,372 · see citing works
What is cognitive reserve? Theory and research application of the reserve concept
STERN, Y. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813248 · Cited by 3,951 · see citing works
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
Schneider, J. A., Arvanitakis, Z., Bang, W., & Bennett, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000271090.28148.24 · Cited by 1,992 · see citing works
Self-citationAging Gracefully: Compensatory Brain Activity in High-Performing Older Adults
Cabeza, R., Anderson, N. D., Locantore, J. K., & McIntosh, A. R. (2002) · NeuroImage · doi:10.1006/nimg.2002.1280 · Cited by 1,964 · see citing works
Loneliness and Risk of Alzheimer Disease
Wilson, R. S., Krueger, K. R., Arnold, S. E., Schneider, J. A., Kelly, J. F., Barnes, L. L., Tang, Y., & Bennett, D. A. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.234 · Cited by 1,363 · see citing works
Self-citationNeuropathology of older persons without cognitive impairment from two community-based studies
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C., & Wilson, R. S. (2006) · Neurology · doi:10.1212/01.wnl.0000219668.47116.e6 · Cited by 1,336 · see citing works
Self-citationFearn, T., Gelman, A., Carlin, J., Stern, H., & Rubin, D. B. (1996) · Biometrics · doi:10.2307/2533081 · Cited by 1,322 · see citing works
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
Individual differences in rates of change in cognitive abilities of older persons.
Wilson, R. S., Beckett, L. A., Barnes, L. L., Schneider, J. A., Bach, J., Evans, D. A., & Bennett, D. A. (2002) · Psychology and Aging · doi:10.1037/0882-7974.17.2.179 · Cited by 842 · see citing works
Self-citationOverview and Findings from the Rush Memory and Aging Project
Bennett, D. A., Schneider, J. A., Buchman, A. S., Barnes, L. L., Boyle, P. A., & Wilson, R. S. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322663 · Cited by 837 · see citing works
Self-citationSynaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
Scheff, S. W., Price, D. A., Schmitt, F. A., DeKosky, S. T., & Mufson, E. J. (2007) · Neurology · doi:10.1212/01.wnl.0000260698.46517.8f · Cited by 824 · see citing works
Neuropathology of Cognitively Normal Elderly
Knopman, D. S., Parisi, J. E., Salviati, A., Floriach-Robert, M., Boeve, B. F., Ivnik, R. J., Smith, G. E., Dickson, D. W., Johnson, K. A., Petersen, L. E., et al. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.11.1087 · Cited by 674 · see citing works
Overview and Findings from the Religious Orders Study
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., & Wilson, R. S. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322573 · Cited by 647 · see citing works
Self-citationCrystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Masdeu, J., Kawas, C., Aronson, M., & Wolfson, L. (1988) · Neurology · doi:10.1212/wnl.38.11.1682 · Cited by 586 · see citing works
Pathological correlates of dementia in a longitudinal, population‐based sample of aging
Sonnen, J. A., Larson, E. B., Crane, P. K., Haneuse, S., Li, G., Schellenberg, G. D., Craft, S., Leverenz, J. B., & Montine, T. J. (2007) · Annals of Neurology · doi:10.1002/ana.21208 · Cited by 432 · see citing works
Microinfarct Pathology, Dementia, and Cognitive Systems
Arvanitakis, Z., Leurgans, S. E., Barnes, L. L., Bennett, D. A., & Schneider, J. A. (2011) · Stroke · doi:10.1161/strokeaha.110.595082 · Cited by 404 · see citing works
Self-citationRiley, K. P., Snowdon, D. A., & Markesbery, W. R. (2002) · Annals of Neurology · doi:10.1002/ana.10161 · Cited by 392 · see citing works
Neural reserve, neuronal density in the locus ceruleus, and cognitive decline
Wilson, R. S., Nag, S., Boyle, P. A., Hizel, L. P., Yu, L., Buchman, A. S., Schneider, J. A., & Bennett, D. A. (2013) · Neurology · doi:10.1212/wnl.0b013e3182897103 · Cited by 275 · see citing works
Self-citationCognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies
Schneider, J. A., Arvanitakis, Z., Yu, L., Boyle, P. A., Leurgans, S. E., & Bennett, D. A. (2012) · Brain · doi:10.1093/brain/aws234 · Cited by 273 · see citing works
Self-citationNeurodegenerative basis of age-related cognitive decline
Wilson, R. S., Leurgans, S. E., Boyle, P. A., Schneider, J. A., & Bennett, D. A. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f39adc · Cited by 234 · see citing works
Self-citationBoyle, P., Buchman, A., Wilson, R. S., Yu, L., Schneider, J., & Bennett, D. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1487 · Cited by 233 · see citing works
Relation of neuropathology to cognition in persons without cognitive impairment
Bennett, D. A., Wilson, R. S., Boyle, P. A., Buchman, A. S., & Schneider, J. A. (2012) · Annals of Neurology · doi:10.1002/ana.23654 · Cited by 220 · see citing works
Self-citationBoyle, P. A., Yu, L., Wilson, R. S., Gamble, K. J., Buchman, A. S., & Bennett, D. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043647 · Cited by 215 · see citing works
Self-citationCognitive decline in the elderly: an analysis of population heterogeneity
Hayden, K. M., Reed, B., Manly, J. J., Tommet, D., Pietrzak, R. H., Chelune, G. J., Yang, F. M., Revell, A. J., Bennett, D. A., & Jones, R. N. (2011) · Age and Ageing · doi:10.1093/ageing/afr101 · Cited by 169 · see citing works
Self-citationGreen, M. S., Kaye, J. A., & Ball, M. J. (2000) · Neurology · doi:10.1212/wnl.54.1.105 · Cited by 153 · see citing works
Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly
Driscoll, I., Resnick, S. M., Troncoso, J. C., An, Y., O'Brien, R., & Zonderman, A. B. (2006) · Annals of Neurology · doi:10.1002/ana.21031 · Cited by 132 · see citing works
Marchant, N. L., Reed, B., Sanossian, N., Madison, C. M., Kriger, S., Dhada, R., Mack, W. J., DeCarli, C. S., Weiner, M. W., Mungas, D., et al. (2013) · JAMA Neurology · doi:10.1001/2013.jamaneurol.405 · Cited by 123 · see citing works
Hippocampal Sclerosis Contributes to Dementia in the Elderly
Corey‐Bloom, J., Sabbagh, M. N., Bondi, M. W., Hansen, L., Alford, M. F., Masliah, E., & Thal, L. J. (1997) · Neurology · doi:10.1212/wnl.48.1.154 · Cited by 110 · see citing works
Cognitive reserve, presynaptic proteins, and dementia in the elderly
Honer, W. G., Barr, A. M., Sawada, K., Thornton, A. E., Morris, M. C., Leurgans, S. E., Schneider, J. A., & Bennett, D. A. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.38 · Cited by 100 · see citing works
Self-citationBalasubramanian, A. B., Kawas, C. H., Peltz, C. B., Brookmeyer, R., & Corrada, M. M. (2012) · Neurology · doi:10.1212/wnl.0b013e318266fc77 · Cited by 99 · see citing works
Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people
Bennett, D. A. (2005) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.054445 · Cited by 99 · see citing works
Self-citationTremblay, C., St‐Amour, I., Schneider, J. A., Bennett, D. A., & Calon, F. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31822c62cf · Cited by 93 · see citing works
Self-citationCognitive decline in old age: Separating retest effects from the effects of growing older.
Wilson, R. S., Li, Y., Bienias, L., & Bennett, D. A. (2006) · Psychology and Aging · doi:10.1037/0882-7974.21.4.774 · Cited by 77 · see citing works
Self-citationTerminal decline and practice effects in older adults without dementia
Dodge, H. H., Wang, C.-N., Chang, C.-C. H., & Ganguli, M. (2011) · Neurology · doi:10.1212/wnl.0b013e31822b0068 · Cited by 64 · see citing works
Inaba, M., White, L. R., Bell, C., Chen, R., Petrovitch, H., Launer, L. J., Abbott, R. D., Ross, G. W., & Masaki, K. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03490.x · Cited by 52 · see citing works
Predictors of Preclinical Alzheimer Disease and Dementia: A Clinicopathologic Study
Galvin, J. E., Powlishta, K. K., Wilkins, K., McKeel, D. W., Xiong, C., Grant, E., Storandt, M., & Morris, J. C. (2005) · Archives of Neurology · doi:10.1001/archneur.62.5.758 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [29]Schneider JA Arvanitakis Z Bang W Bennett DA Mixed brain pathologic indices account for most dementia cases in community-dwelling older persons. Neurology 2007 69 24 2197 204 17568013
Cited by
Sorted by citations
Scheltens, P., Blennow, K., Breteler, M. M. B., de Strooper, B., Frisoni, G. B., Salloway, S., & Van der Flier, W. M. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01124-1 · Cited by 3,125 · see citing works
Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., Rademakers, R., Alafuzoff, I., Attems, J., Brayne, C., et al. (2019) · Brain · doi:10.1093/brain/awz099 · Cited by 1,547 · see citing works
Self-citationThe Impact of Age on Cognition
Murman, D. (2015) · Seminars in Hearing · doi:10.1055/s-0035-1555115 · Cited by 1,619 · see citing works
Religious Orders Study and Rush Memory and Aging Project
Bennett, D. A., Buchman, A. S., Boyle, P. A., Barnes, L. L., Wilson, R. S., & Schneider, J. A. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179939 · Cited by 1,260 · see citing works
Self-citationHow Does it STAC Up? Revisiting the Scaffolding Theory of Aging and Cognition
Reuter‐Lorenz, P. A., & Park, D. C. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9270-9 · Cited by 955 · see citing works
Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve
Barulli, D., & Stern, Y. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.012 · Cited by 924 · see citing works
The overlap between vascular disease and Alzheimer’s disease - lessons from pathology
Attems, J., & Jellinger, K. A. (2014) · BMC Medicine · doi:10.1186/s12916-014-0206-2 · Cited by 739 · see citing works
“However, much of the variation in cognitive decline remains unexplained, suggesting that other important determinants of cognitive decline remain to be identified [156].”
BackgroundNguyen, P. H., Ramamoorthy, A., Sahoo, B. R., Zheng, J., Faller, P., Straub, J. E., Domı́nguez, L., Shea, J., Dokholyan, N. V., Simone, A. D., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01122 · Cited by 676 · see citing works
β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation
Mander, B. A., Marks, S. M., Vogel, J. W., Rao, V. R., Lu, B. S., Saletin, J., Ancoli‐Israel, S., Jagust, W. J., & Walker, M. P. (2015) · Nature Neuroscience · doi:10.1038/nn.4035 · Cited by 546 · see citing works
Mostafavi, S., Gaiteri, C., Sullivan, S. E., White, C. C., Tasaki, S., Xu, J., Taga, M., Klein, H.-U., Patrick, E., Komashko, V., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0154-9 · Cited by 509 · see citing works
Self-citationPerson-specific contribution of neuropathologies to cognitive loss in old age
Boyle, P. A., Yu, L., Wilson, R. S., Leurgans, S. E., Schneider, J. A., & Bennett, D. A. (2018) · Annals of Neurology · doi:10.1002/ana.25123 · Cited by 508 · see citing works
Self-citationClifford, A., Lang, L., Chen, R., Anstey, K. J., & Seaton, A. (2016) · Environmental Research · doi:10.1016/j.envres.2016.01.018 · Cited by 496 · see citing works
Levine, M. E., Lu, A. T., Bennett, D. A., & Horvath, S. (2015) · Aging · doi:10.18632/aging.100864 · Cited by 455 · see citing works
Self-citationTDP-43 stage, mixed pathologies, and clinical Alzheimer’s-type dementia
James, B. D., Wilson, R. S., Boyle, P. A., Trojanowski, J. Q., Bennett, D. A., & Schneider, J. A. (2016) · Brain · doi:10.1093/brain/aww224 · Cited by 407 · see citing works
Self-citationCerebral amyloid angiopathy and cognitive outcomes in community-based older persons
Boyle, P. A., Yu, L., Nag, S., Leurgans, S., Wilson, R. S., Bennett, D. A., & Schneider, J. A. (2015) · Neurology · doi:10.1212/wnl.0000000000002175 · Cited by 423 · see citing works
Self-citationDefining Cognitive Reserve and Implications for Cognitive Aging
Pettigrew, C. A., & Soldan, A. (2019) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-019-0917-z · Cited by 437 · see citing works
A major role for cardiovascular burden in age-related cognitive decline
Qiu, C., & Fratiglioni, L. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.223 · Cited by 401 · see citing works
Prevalence of mixed pathologies in the aging brain
Rahimi, J., & Kovács, G. G. (2014) · Alzheimer s Research & Therapy · doi:10.1186/s13195-014-0082-1 · Cited by 365 · see citing works
B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke
Doyle, K. P., Quach, L. N., Solé, M., Axtell, R. C., Nguyen, T. V., Soler-Llavina, G. J., Jurado, S., Han, J., Steinman, L., Longo, F. M., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4098-14.2015 · Cited by 338 · see citing works
Self-citationAttributable risk of Alzheimer's dementia attributed to age-related neuropathologies
Boyle, P. A., Yu, L., Leurgans, S. E., Wilson, R. S., Brookmeyer, R., Schneider, J. A., & Bennett, D. A. (2019) · Annals of Neurology · doi:10.1002/ana.25380 · Cited by 318 · see citing works
Self-citationEntorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging
Maaß, A., Lockhart, S. N., Harrison, T. M., Bell, R. K., Mellinger, T. J., Swinnerton, K. N., Baker, S. L., Rabinovici, G. D., & Jagust, W. J. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2028-17.2017 · Cited by 288 · see citing works
Davis, D. H. J., Muniz-Terrera, G., Keage, H. A. D., Stephan, B. C. M., Fleming, J., Ince, P. G., Matthews, F. E., Cunningham, C., Ely, E. W., MacLullich, A. M. J., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.3423 · Cited by 252 · see citing works
TDP-43 Pathology, Cognitive Decline, and Dementia in Old Age
Wilson, R. S., Yu, L., Trojanowski, J. Q., Chen, E., Boyle, P. A., Bennett, D. A., & Schneider, J. A. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.3961 · Cited by 248 · see citing works
Self-citationGarwood, C. J., Ratcliffe, L. E., Simpson, J. E., Heath, P. R., Ince, P. G., & Wharton, S. B. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12338 · Cited by 233 · see citing works
Dietary fat composition and dementia risk
Morris, M. C., & Tangney, C. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.038 · Cited by 222 · see citing works
To what degree is late life cognitive decline driven by age-related neuropathologies?
Boyle, P. A., Wang, T., Yu, L., Wilson, R. S., Dawe, R. J., Arfanakis, K., Schneider, J. A., & Bennett, D. A. (2021) · Brain · doi:10.1093/brain/awab092 · Cited by 215 · see citing works
Self-citationCombined neuropathological pathways account for age‐related risk of dementia
Power, M. C., Mormino, E. C., Soldan, A., James, B. D., Yu, L., Armstrong, N. M., Bangen, K. J., Delano‐Wood, L., Lamar, M., Lim, Y. Y., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25246 · Cited by 215 · see citing works
Self-citationMorris, G. P., Clark, I. A., & Vissel, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1918-8 · Cited by 212 · see citing works
Wingo, A. P., Dammer, E. B., Breen, M. S., Logsdon, B. A., Duong, D. M., Troncosco, J. C., Thambisetty, M., Beach, T. G., Serrano, G. E., Reiman, E. M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09613-z · Cited by 211 · see citing works
Causes and Patterns of Dementia: An Update in the Era of Redefining Alzheimer's Disease
James, B. D., & Bennett, D. A. (2019) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040218-043758 · Cited by 200 · see citing works
Self-citationCoupled cognitive changes in adulthood: A meta-analysis.
Tucker–Drob, E. M., Brandmaier, A. M., & Lindenberger, U. (2019) · Psychological Bulletin · doi:10.1037/bul0000179 · Cited by 197 · see citing works
Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease
Nelson, P. T., Smith, C. D., Abner, E. L., Wilfred, B. R., Wang, W., Neltner, J. H., Baker, M., Fardo, D. W., Kryscio, R. J., Scheff, S. W., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1154-1 · Cited by 196 · see citing works
Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample
Brenowitz, W. D., Hubbard, R. A., Keene, C. D., Hawes, S. E., Longstreth, W. T., Woltjer, R. L., & Kukull, W. A. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.09.015 · Cited by 188 · see citing works
Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies
White, L. R., Edland, S. D., Hemmy, L. S., Montine, K. S., Zarow, C., Sonnen, J. A., Uyehara‐Lock, J. H., Gelber, R. P., Ross, G. W., Petrovitch, H., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002480 · Cited by 171 · see citing works
Odor identification and Alzheimer disease biomarkers in clinically normal elderly
Growdon, M. E., Schultz, A. P., Dagley, A. S., Amariglio, R. E., Hedden, T., Rentz, D. M., Johnson, K. A., Sperling, R. A., Albers, M. W., & Marshall, G. A. (2015) · Neurology · doi:10.1212/wnl.0000000000001614 · Cited by 159 · see citing works
Predictors of ageing-related decline across multiple cognitive functions
Ritchie, S. J., Tucker-Drob, E. M., Cox, S. R., Corley, J., Dykiert, D., Redmond, P., Pattie, A., Taylor, A. M., Sibbett, R., Starr, J. M., et al. (2016) · Intelligence · doi:10.1016/j.intell.2016.08.007 · Cited by 147 · see citing works
Brain and blood metabolome for Alzheimer's dementia: findings from a targeted metabolomics analysis
Huo, Z., Yu, L., Yang, J., Zhu, Y., Bennett, D. A., & Zhao, J. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.014 · Cited by 154 · see citing works
Self-citationKarr, J. E., Graham, R., Hofer, S. M., & Terrera, G. M. (2018) · Psychology and Aging · doi:10.1037/pag0000236 · Cited by 147 · see citing works
Multicellular communities are perturbed in the aging human brain and Alzheimer’s disease
Cain, A., Taga, M., McCabe, C., Green, G. S., Hekselman, I., White, C. C., Lee, D. I., Gaur, P., Rozenblatt-Rosen, O., Zhang, F., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01356-x · Cited by 142 · see citing works
Self-citationChallenges of multimorbidity of the aging brain: a critical update
Jellinger, K. A., & Attems, J. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-014-1288-x · Cited by 154 · see citing works
Brain Renin–Angiotensin System at the Intersect of Physical and Cognitive Frailty
Cosarderelioglu, C., Nidadavolu, L. S., George, C. J., Oh, E. S., Bennett, D. A., Walston, J. D., & Abadir, P. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.586314 · Cited by 134 · see citing works
Self-citationVaried effects of age-related neuropathologies on the trajectory of late life cognitive decline
Boyle, P. A., Yang, J., Yu, L., Leurgans, S. E., Capuano, A. W., Schneider, J. A., Wilson, R. S., & Bennett, D. A. (2016) · Brain · doi:10.1093/brain/aww341 · Cited by 129 · see citing works
Self-citationCortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons
Yu, L., Tasaki, S., Schneider, J. A., Arfanakis, K., Duong, D. M., Wingo, A. P., Wingo, T. S., Kearns, N., Thatcher, G. R. J., Seyfried, N. T., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.1807 · Cited by 127 · see citing works
Self-citationEpigenomics of Alzheimer's disease
Bennett, D. A., Yu, L., Yang, J., Srivastava, G. P., Aubin, C., & Jager, P. L. D. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.006 · Cited by 124 · see citing works
Self-citationClinical and imaging features of mixed Alzheimer and vascular pathologies
Chui, H. C., & Ramirez-Gomez, L. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0104-7 · Cited by 124 · see citing works
Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia
Yu, L., Petyuk, V. A., Gaiteri, C., Mostafavi, S., Young‐Pearse, T., Shah, R. C., Buchman, A. S., Schneider, J. A., Piehowski, P. D., Sontag, R. L., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25266 · Cited by 124 · see citing works
Self-citationMeasuring cognition and function in the preclinical stage of Alzheimer's disease
Weintraub, S., Carrillo, M., Farias, S., Goldberg, T., Hendrix, J. A., Jaeger, J., Knopman, D., Langbaum, J., Park, D. C., Ropacki, M., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.trci.2018.01.003 · Cited by 120 · see citing works
Leveraging preclinical models for the development of Alzheimer disease therapeutics
Scearce-Levie, K. A., Sanchez, P. E., & Lewcock, J. W. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0065-9 · Cited by 118 · see citing works
APP/Aβ structural diversity and Alzheimer's disease pathogenesis
Roher, A. E., Kokjohn, T. A., Clarke, S. G., Sierks, M. R., Maarouf, C. L., Serrano, G. E., Sabbagh, M., & Beach, T. G. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.08.007 · Cited by 121 · see citing works
Stern, Y., & Barulli, D. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00011-x · Cited by 114 · see citing works
White, C. C., Yang, H., Yu, L., Chibnik, L. B., Dawe, R. J., Yang, J., Klein, H., Felsky, D., Ramos‐Miguel, A., Arfanakis, K., et al. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002287 · Cited by 108 · see citing works
Self-citationRelation of neuropathology with cognitive decline among older persons without dementia
Boyle, P. A., Yu, L., Wilson, R. S., Schneider, J. A., & Bennett, D. A. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00050 · Cited by 105 · see citing works
Self-citationCoupled Changes in Brain White Matter Microstructure and Fluid Intelligence in Later Life
Ritchie, S. J., Bastin, M. E., Tucker–Drob, E. M., Maniega, S. M., Engelhardt, L. E., Cox, S. R., Royle, N. A., Gow, A. J., Corley, J., Pattie, A., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0862-15.2015 · Cited by 98 · see citing works
Genetic variants in Alzheimer disease — molecular and brain network approaches
Gaiteri, C., Mostafavi, S., Honey, C. J., Jager, P. L. D., & Bennett, D. A. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.84 · Cited by 96 · see citing works
Self-citationNormative Cognitive Decline in Old Age
Wilson, R. S., Wang, T., Yu, L., Bennett, D. A., & Boyle, P. A. (2020) · Annals of Neurology · doi:10.1002/ana.25711 · Cited by 90 · see citing works
Self-citationNegative social interactions and risk of mild cognitive impairment in old age
Wilson, R. S., Boyle, P. A., James, B. D., Leurgans, S. E., Buchman, A. S., & Bennett, D. A. (2015) · Neuropsychology · doi:10.1037/neu0000154 · Cited by 87 · see citing works
Alzheimer’s Disease Neuropathological Comorbidities are Common in the Younger-Old
Beach, T. G., & Malek‐Ahmadi, M. H. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201213 · Cited by 84 · see citing works
The role of regulatory T cells in nervous system pathologies
Duffy, S. S., Keating, B. A., Perera, C. J., & Moalem‐Taylor, G. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24073 · Cited by 85 · see citing works
Mehta, R. I., & Schneider, J. A. (2021) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000912 · Cited by 84 · see citing works
Self-citationDawe, R. J., Yu, L., Arfanakis, K., Schneider, J. A., Bennett, D. A., & Boyle, P. A. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12009 · Cited by 79 · see citing works
Self-citationConscientiousness, dementia related pathology, and trajectories of cognitive aging.
Wilson, R. S., Boyle, P. A., Yu, L., Segawa, E., Sytsma, J., & Bennett, D. A. (2015) · Psychology and Aging · doi:10.1037/pag0000013 · Cited by 81 · see citing works
Self-citationCarmo, S. D., Hanzel, C. E., Jacobs, M. L., Machnes, Z. M., Iulita, M. F., Yang, J., Yu, L., Ducatenzeiler, A., Danik, M., Breuillaud, L., et al. (2016) · Scientific Reports · doi:10.1038/srep34051 · Cited by 79 · see citing works
Self-citationTOMM40 ′523 variant and cognitive decline in older persons with APOE ε3/3 genotype
Yu, L., Lutz, M. W., Wilson, R. S., Burns, D. K., Roses, A. D., Saunders, A. M., Gaiteri, C., Jager, P. L. D., Barnes, L. L., & Bennett, D. A. (2017) · Neurology · doi:10.1212/wnl.0000000000003614 · Cited by 78 · see citing works
Self-citationde Vries, L. E., Huitinga, I., Kessels, H. W. H. G., Swaab, D. F., & Verhaagen, J. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00719-7 · Cited by 82 · see citing works
Relation of genomic variants for Alzheimer disease dementia to common neuropathologies
Farfel, J. M., Yu, L., Buchman, A. S., Schneider, J. A., De Jager, P. L., & Bennett, D. A. (2016) · Neurology · doi:10.1212/wnl.0000000000002909 · Cited by 64 · see citing works
Self-citationResidual decline in cognition after adjustment for common neuropathologic conditions.
Yu, L., Boyle, P. A., Segawa, E., Leurgans, S. E., Schneider, J. A., Wilson, R. S., & Bennett, D. A. (2014) · Neuropsychology · doi:10.1037/neu0000159 · Cited by 71 · see citing works
Self-citationWingo, T. S., Yang, J., Fan, W., Canon, S. M., Gerasimov, E. S., Lori, A., Logsdon, B. A., Yao, B., Seyfried, N. T., Lah, J. J., et al. (2020) · npj Genomic Medicine · doi:10.1038/s41525-019-0113-8 · Cited by 70 · see citing works
Self-citationCognitive debt and Alzheimer’s disease
Marchant, N. L., & Howard, R. J. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-141515 · Cited by 68 · see citing works
Boyle, R. T., Knight, S. P., Looze, C. D., Carey, D., Scarlett, S., Stern, Y., Robertson, I. H., Kenny, R. A., & Whelan, R. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00870-z · Cited by 69 · see citing works
Representation of Older Latinxs in Cohort Studies at the Rush Alzheimer’s Disease Center
Márquez, D. X., Glover, C. M., Lamar, M., Leurgans, S. E., Shah, R. C., Barnes, L. L., Aggarwal, N. T., Buchman, A. S., & Bennett, D. A. (2020) · Neuroepidemiology · doi:10.1159/000509626 · Cited by 65 · see citing works
Self-citationBrain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline
Hüls, A., Robins, C., Conneely, K. N., Edgar, R. D., Jager, P. L. D., Bennett, D. A., Wingo, A. P., Epstein, M. P., & Wingo, T. S. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.01.015 · Cited by 63 · see citing works
Self-citation(ADNI), A. D. N. I., Kleineidam, L., Chouraki, V., Próchnicki, T., van der Lee, S. J., Madrid-Márquez, L., Wagner-Thelen, H., Karaca, I., Weinhold, L., Wolfsgruber, S., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02138-6 · Cited by 62 · see citing works
Associations Between Personality Traits and Cognitive Resilience in Older Adults
Graham, E. K., James, B. D., Jackson, K., Willroth, E. C., Boyle, P. A., Wilson, R., Bennett, D. A., & Mroczek, D. K. (2020) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbaa135 · Cited by 61 · see citing works
Self-citationBennett, D. A. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002256 · Cited by 61 · see citing works
Self-citationVascular and neurodegenerative pathways—will they meet?
Kalaria, R. N., & Ihara, M. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.164 · Cited by 60 · see citing works
The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia
Tasaki, S., Gaiteri, C., Mostafavi, S., Jager, P. L. D., & Bennett, D. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00699 · Cited by 58 · see citing works
Self-citationAssociation of genetic risk factors with cognitive decline: the PATH through life project
Andrews, S. J., Das, D., Cherbuin, N., Anstey, K. J., & Easteal, S. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.016 · Cited by 59 · see citing works
The prognosis of mild cognitive impairment: A systematic review and meta‐analysis
Salemme, S., Lombardo, F. L., Lacorte, E., Sciancalepore, F., Remoli, G., Bacigalupo, I., Piscopo, P., Zamboni, G., Rossini, P. M., Cappa, S. F., et al. (2025) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70074 · Cited by 58 · see citing works
Ramos‐Miguel, A., Beasley, C. L., Dwork, A. J., Mann, J. J., Rosoklija, G. B., Barr, A. M., & Honer, W. G. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.012 · Cited by 58 · see citing works
Self-citationPrediction of Long-term Cognitive Decline Following Postoperative Delirium in Older Adults
Devore, E. E., Fong, T. G., Marcantonio, E. R., Schmitt, E. M., Travison, T. G., Jones, R. N., & Inouye, S. K. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx030 · Cited by 58 · see citing works
Bennett, D. A., Yu, L., & Jager, P. L. D. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.037 · Cited by 53 · see citing works
Self-citationBeach, T., Malek-Ahmadi, M., ZAMRINI, E. Y., Adler, C. H., Sabbagh, M. N., Shill, H. A., Jacobson, S. A., Belden, C. M., Caselli, R. J., Woodruff, B. K., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217566 · Cited by 56 · see citing works
Late‐life physical activity relates to brain tissue synaptic integrity markers in older adults
Casaletto, K., Ramos‐Miguel, A., VandeBunte, A., Memel, M., Buchman, A., Bennett, D., & Honer, W. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12530 · Cited by 53 · see citing works
Self-citationCognitive Reserve as a Useful Concept for Early Intervention Research in Multiple Sclerosis
Sumowski, J. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00176 · Cited by 55 · see citing works
MRI-based evaluation of structural degeneration in the ageing brain: Pathophysiology and assessment
Grajauskas, L. A., Siu, W. W. Y., Medvedev, G., Guo, H., D’Arcy, R. C. N., & Song, X. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.11.004 · Cited by 56 · see citing works
Nilsson, J., & Lövdén, M. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0365-z · Cited by 54 · see citing works
Precision Aging: Applying Precision Medicine to the Field of Cognitive Aging
Ryan, L., Hay, M., Huentelman, M. J., Duarte, A., Rundek, T., Levin, B. E., Soldan, A., Pettigrew, C. A., Mehl, M. R., & Barnes, C. A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00128 · Cited by 54 · see citing works
Geerts, H., Wikswo, J. P., van der Graaf, P. H., Bai, J. P. F., Gaiteri, C., Bennett, D. A., Swalley, S. E., Schuck, E. L., Kaddurah‐Daouk, R., Tsaioun, K., et al. (2019) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12478 · Cited by 49 · see citing works
Self-citationCognitive impairment and World Trade Centre-related exposures
Clouston, S., Hall, C. B., Kritikos, M., Bennett, D. A., DeKosky, S. T., Edwards, J. D., Finch, C. E., Kreisl, W. C., Mielke, M. M., Peskind, E. R., et al. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00576-8 · Cited by 52 · see citing works
Self-citationCasaletto, K. B., Lindbergh, C. A., VandeBunte, A. M., Neuhaus, J., Schneider, J. A., Buchman, A. S., Honer, W. G., & Bennett, D. A. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1483-21.2021 · Cited by 51 · see citing works
Self-citationLewy body pathology in Alzheimer's disease: A clinicopathological prospective study
Savica, R., Beach, T. G., Hentz, J. G., Sabbagh, M. N., Serrano, G. E., Sue, L. I., Dugger, B. N., Shill, H. A., Driver‐Dunckley, E. D., Caviness, J. N., et al. (2018) · Acta Neurologica Scandinavica · doi:10.1111/ane.13028 · Cited by 51 · see citing works
Dynamic change of cognitive reserve: associations with changes in brain, cognition, and diagnosis
Bettcher, B. M., Gross, A. L., Gavett, B. E., Widaman, K. F., Fletcher, E., Dowling, N. M., Buckley, R. F., Arenaza‐Urquijo, E. M., Zahodne, L. B., Hohman, T. J., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.08.016 · Cited by 51 · see citing works
Cognitive function in older adults according to current socioeconomic status
Zhang, M., Gale, S. D., Erickson, L. D., Brown, B. L., Woody, P., & Hedges, D. W. (2015) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2014.997663 · Cited by 50 · see citing works
Biomarkers in subtypes of mild cognitive impairment and subjective cognitive decline
Eliassen, C. F., Reinvang, I., Selnes, P., Grambaitė, R., Fladby, T., & Hessen, E. (2017) · Brain and Behavior · doi:10.1002/brb3.776 · Cited by 50 · see citing works
The process and mechanisms of personality change
Jackson, J. J., & Wright, A. J. (2024) · Nature Reviews Psychology · doi:10.1038/s44159-024-00295-z · Cited by 55 · see citing works
van Rooij, J., Meeter, L. H. H., Melhem, S., Nijholt, D. A. T., Wong, T. H., Rozemüller, A. J. M., Uitterlinden, A. G., van Meurs, J. B. J., & Swieten, J. C. V. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.10.023 · Cited by 50 · see citing works
Perin, S., Buckley, R. F., Pase, M. P., Yassi, N., Lavale, A., Wilson, P. H., Schembri, A. J., Maruff, P. T., & Lim, Y. Y. (2020) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12043 · Cited by 49 · see citing works
Buchman, A. S., & Bennett, D. A. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-013-0397-9 · Cited by 51 · see citing works
Self-citationMontine, T. J., Corrada, M. M., Kawas, C. H., Bukhari, S. A., White, L. R., Tian, L., & Cholerton, B. (2022) · Neurology · doi:10.1212/wnl.0000000000200832 · Cited by 48 · see citing works
A Review of Biomarkers for Neurodegenerative Disease: Will They Swing Us Across the Valley?
Beach, T. G. (2017) · Neurology and Therapy · doi:10.1007/s40120-017-0072-x · Cited by 47 · see citing works
- Authors
- Boyle, P. A., Wilson, R. S., Yu, L., Barr, A. M., Honer, W. G., Schneider, J. A., & Bennett, D. A.
- Affiliations
- Rush University Medical Center (US)
- University of British Columbia (CA)
- Corresponding author
- Boyle, Patricia A.
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2013-07-10
- Volume
- 74
- Issue
- 3
- Pages
- 478-489
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC3845973
- OpenAlex
- W1581476053
- Cited by
- 323
- References
- 39
- Citations by year
- 2026: 17 · 2025: 14 · 2024: 18 · 2023: 21 · 2022: 25 · 2021: 20 · 2020: 26 · 2019: 30 · 2018: 36 · 2017: 31 · 2016: 33 · 2015: 24 · 2014: 17 · 2013: 11
- FWCI
- 20.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research (CBG101827)
- National Institute on Aging (R01 AG33678, R01AG017917, P30-AG 10161, R01-AG34374, R01‐AG17917, R01 AG15819, R01AG015819, P30AG010161, R01AG033678, R01AG034374)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- late-life cognitive decline, Alzheimer's disease, cerebrovascular disease, Lewy body disease, neurodegeneration, neuropathology, amyloid, neurofibrillary tangles, microinfarcts, dementia, cognitive trajectories, older adults, Religious Orders Study
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Brain, Cognition Disorders, Female, Humans, Longitudinal Studies, Male, Nerve Degeneration, Neuropsychological Tests
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review