α‐synuclein in the inner retina in parkinson disease
Abstract
Behavioral, electrophysiological, and imaging data reveal impaired visual processing and altered retinal morphology in Parkinson disease. Are visual changes epiphenomena? We report the presence of misfolded α-synuclein in the retina, not hitherto shown, in discrete retinal neurons within the inner retina. They demonstrate the histopathology that may underlie impaired vision and retinal remodeling in Parkinson disease. Furthermore, the histological localization of α-synuclein gives clues to the nonsynaptic mode of α-synuclein propagation.
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In postmortem PD eyes, α-syn aggregates are observed inside neurons of different retinal layers, including border of INL, IPL, and GCL.
“In postmortem PD eyes, α-syn aggregates have been observed inside the neurons of different retinal layers, including the border of the INL, the IPL, and the GCL.”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Bodis-Wollner et al., 2014
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- Authors
- Bodis‐Wollner, I., Kozlowski, P. B., Glazman, S., & Miri, S.
- Affiliations
- Departments of Neurology SUNY Downstate Medical Center Brooklyn
- Touro College (US)
- SUNY Downstate Health Sciences University (US)
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2014-06
- Volume
- 75
- Issue
- 6
- Pages
- 964-966
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1956487664
- Cited by
- 192
- References
- 20
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 20 · 2023: 28 · 2022: 15 · 2021: 16 · 2020: 24 · 2019: 10 · 2018: 17 · 2017: 18 · 2016: 14 · 2015: 9
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Parkinson Study Group (64166)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- alpha-synuclein, Parkinson's disease, inner retina, retinal neurons, protein misfolding, retinal histopathology, visual impairment, retinal remodeling, alpha-synuclein propagation
- MeSH terms
- Female, Humans, Male, Parkinson Disease, Retina, alpha-Synuclein
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