The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders
Open accessAbstract
OBJECTIVE: The diagnosis of mitochondrial disorders (MDs) is occasionally difficult because patients often present with solitary, or a combination of, symptoms caused by each organ insufficiency, which may be the result of respiratory chain enzyme deficiency. Growth differentiation factor 15 (GDF-15) has been reported to be elevated in serum of patients with MDs. In this study, we investigated whether GDF-15 is a more useful biomarker for MDs than several conventional biomarkers. METHODS: We measured the serum levels of GDF-15 and fibroblast growth factor 21 (FGF-21), as well as other biomarkers, in 48 MD patients and in 146 healthy controls in Japan. GDF-15 and FGF-21 concentrations were measured by enzyme-linked immunosorbant assay and compared with lactate, pyruvate, creatine kinase, and the lactate-to-pyruvate ratio. We calculated sensitivity and specificity and also evaluated the correlation based on two rating scales, including the Newcastle Mitochondrial Disease Rating Scale (NMDAS). RESULTS: Mean GDF-15 concentration was 6-fold higher in MD patients compared to healthy controls (2,711 ± 2,459 pg/ml vs 462.5 ± 141.0 pg/mL; p < 0.001). Using a receiver operating characteristic curve, the area under the curve was significantly higher for GDF-15 than FGF-21 and other conventional biomarkers. Our date suggest that GDF-15 is the most useful biomarker for MDs of the biomarkers examined, and it is associated with MD severity. INTERPRETATION: Our results suggest that measurement of GDF-15 is the most useful first-line test to indicate the patients who have the mitochondrial respiratory chain deficiency.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It is considered as an indicator of mitochondrial dysfunction in muscle (21)”
From Human Aging and Longevity Are Characterized by High Levels of Mitokines (2019) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
DeLong, E. R., DeLong, D. M., & Clarke-Pearson, D. L. (1988) · Biometrics · doi:10.2307/2531595 · Cited by 22,649
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M. A., Sadri, N., Yun, C., Popko, B., Paules, R. S., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00105-9 · Cited by 3,336
Suomalainen, A., Elo, J. M., Pietiläinen, K. H., Hakonen, A. H., Sevastianova, K., Korpela, M., Isohanni, P., Marjavaara, S. K., Tyni, T., Kiuru-Enari, S., et al. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70155-7 · Cited by 427
MELAS: A nationwide prospective cohort study of 96 patients in Japan
Yatsuga, S., Povalko, N., Nishioka, J., Katayama, K., Kakimoto, N., Matsuishi, T., Kakuma, T., & Koga, Y. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.03.015 · Cited by 309
Mitochondrial Disease: A Practical Approach for Primary Care Physicians
Haas, R., Parikh, S., Falk, M. J., Saneto, R. P., Wolf, N. I., Darín, N., & Cohen, B. H. (2007) · PEDIATRICS · doi:10.1542/peds.2007-0391 · Cited by 272
Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
De Sousa-Coelho, A. L., Marrero, P. F., & Haro, D. (2012) · Biochemical Journal · doi:10.1042/bj20111748 · Cited by 246
Santhanakrishnan, R., Chong, J. P. C., Ng, T. P., Ling, L. H., Sim, D., Leong, K. T. G., Yeo, P. S. D., Ong, H. Y., Jaufeerally, F. R., Wong, R. C.-C., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs130 · Cited by 217
Jiang, S., Cheng, Y., Fang, Q., Shao, M., Zhang, Y., Liu, Y., Deng, Y., Shan, B., Liu, J., Li, H., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.565960 · Cited by 182
Mitochondrial disease in adults: A scale to monitor progression and treatment
Schaefer, A. M., Phoenix, C., Elson, J. L., McFarland, R., Chinnery, P. F., & Turnbull, D. M. (2006) · Neurology · doi:10.1212/01.wnl.0000219759.72195.41 · Cited by 178
Jousse, C., Deval, C., Maurin, A., Parry, L., Chérasse, Y., Chaveroux, C., LeFloch, R., Lenormand, P., Bruhat, A., & Fafournoux, P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611723200 · Cited by 174
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–293 of 293
FGF21 and GDF15 are elevated in Barth Syndrome and are correlated to important clinical measures
Liu, O., Chinni, B. K., Manlhiot, C., & Vernon, H. J. (2023) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2023.107676 · Cited by 6
Fukuda, M., & Nagao, Y. (2019) · Journal of Medical Case Reports · doi:10.1186/s13256-019-2255-9 · Cited by 6
Alcohol-Related Central Nervous System Disorders Associated with Vitamin B Deficiency
Tetsuka, S., & Hashimoto, R. (2021) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-021-00741-6 · Cited by 5
The neuro-ophthalmology of inherited myopathies
Watson, E. C., Ahmad, K. E., & Fraser, C. L. (2019) · Current Opinion in Ophthalmology · doi:10.1097/icu.0000000000000610 · Cited by 6
The swinging pendulum of biomarkers in mitochondrial disease
Steele, H. E., Horváth, R., & Taylor, R. W. (2016) · Neurology · doi:10.1212/wnl.0000000000003383 · Cited by 6
Moghadam, B. H., Johne, M., Golestani, F., Lorenz, K., Asad, M., Maculewicz, E., & Mastalerz, А. (2023) · Biology of Sport · doi:10.5114/biolsport.2023.123894 · Cited by 5
Liu, C. C., Kurade, M., Monzel, A. S., Kelly, C. A., Juster, R., Trumpff, C., Hirano, M., & Picard, M. A. (2026) · Neurology Genetics · doi:10.1212/nxg.0000000000200343 · Cited by 5
Chen, Y.-C., Chen, J.-H., Tsai, C., Wu, C.-T., Chang, P.-C., & Yeh, W. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.116818 · Cited by 5
Synthetic aporphine alkaloids are potential therapeutics for Leigh syndrome
Kobayashi, M., Miyauchi, A., Jimbo, E. F., Oishi, N., Aoki, S., Watanabe, M., Yoshikawa, Y., Akiyama, Y., Yamagata, T., & Osaka, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-62445-w · Cited by 5
Endurance swimming exacerbates mitochondrial myopathy in mice with high mtDNA deletions
Hanada, S., Ishikawa, K., Shirai, T., Takemasa, T., & Nakada, K. (2025) · Mitochondrion · doi:10.1016/j.mito.2025.102010 · Cited by 5
Gao, R., Gu, L., Zuo, W., & Wang, P. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1491283 · Cited by 5
Tissue-specific adaptations to cytochrome c oxidase deficiency shape physiological outcomes
Popović, M., Isermann, L., Geißen, S., Senft, K., Georgomanolis, T., Baldus, S. E., Frezza, C., & Trifunović, A. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167567 · Cited by 4
Wang, B., Qi, M.-Y., Yang, Z., He, G., & Meng, S.-Y. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1486361 · Cited by 4
Chinopoulos, C. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.11.004 · Cited by 4
Fernández, A. C., Estrella, J. F. G. L., Oglesbee, D., Larson, A. A., & Hove, J. L. K. V. (2024) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12821 · Cited by 4
Ahmadi, Z. A., & Brandt, U. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167996 · Cited by 6
Updates on Mitochondrial Myopathies
Barca, E., & Emmanuele, V. (2025) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-025-01444-4 · Cited by 3
Cianfruglia, L., Pazmay, G. V. B., Fortunato, C., Spezia, P. G., Novazzi, F., Piacenza, F., Malavolta, M., Marchegiani, F., Recchioni, R., Matacchione, G., et al. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112978 · Cited by 3
Inhibition of GDF15/GFRAL: A novel opportunity for the treatment of solid tumors
Zhang, P., Liu, Y., Yang, H., Li, J., Fan, G., Bai, H., Cao, X., & Li, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.116109 · Cited by 6
Oppenheimer, K. R., Himelhoch, N. T., McCullough, M. E., BOWDEN, T. L., Kandasamy, B., Letourneau, L. R., Naylor, R. N., Greeley, S. A. W., & Philipson, L. H. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf698 · Cited by 3
Non-invasive biomarkers for diagnosis and monitoring of primary mitochondrial diseases
Arena, I. G., Saravanabavan, S., Horváth, R., & van den Ameele, J. (2026) · Journal of Neurology · doi:10.1007/s00415-026-13794-1 · Cited by 3
Mitochondrial cardiomyopathy: bridging molecular mechanisms and clinical frontiers
Imai‐Okazaki, A., Pei, L., & Wallace, D. C. (2026) · Nature Reviews Cardiology · doi:10.1038/s41569-026-01301-y · Cited by 3
Erngren, I., Lundblad, K., Pavlović, I., Al-Grety, A., Larsson, A. O., Kultima, K., & Burman, J. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03511-6 · Cited by 3
Miyaue, N., Yabe, H., & Nagai, M. (2020) · Neurology and Clinical Neuroscience · doi:10.1111/ncn3.12390 · Cited by 2
Gojanovich, G. S., Jacobson, D. L., Broadwell, C., Karalius, B., Kirmse, B., Geffner, M. E., Jao, J. K., Dyke, R. B. V., McFarland, E. J., Silió, M., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0261563 · Cited by 3
Disorders of Oxidative Phosphorylation
Rahman, S., & Mayr, J. A. (2022) · Springer eBooks · doi:10.1007/978-3-662-63123-2_10 · Cited by 3
Oxidative damage and mitochondrial dysfunction in cystathionine beta-synthase deficiency
Balcı, M. C., Gedikbaşı, A., Doğan, Ş. A., Kahraman, S., Tatoryan, S., Neijmann, S. T., Karaca, M., Atalar, F., & Gökçay, G. (2024) · Scientific Reports · doi:10.1038/s41598-024-80273-w · Cited by 2
Sun, Y., Tang, S., Jingwei, L., Bing, W., Xu, J., Busu, L., Zhao, B. T., Ji, K., & Yan, C. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-025-03651-1 · Cited by 2
Clinical Heterogeneity and Candidate Biomarkers in POLG -Related Mitochondrial Disease
Bermejo‐Guerrero, L., Restrepo‐Vera, J. L., Martín‐Jiménez, P., Navarro-Riquelme, M., Garrido-Moraga, R., Ochoa, L. E., González-Quintana, A., Hernández‐Laín, A., Castillo-Villalba, J., Morís, G., et al. (2026) · Neurology Genetics · doi:10.1212/nxg.0000000000200365 · Cited by 3
Wang, S., Chou, H.-Y., Liu, P.-H., Su, H.-H., Hung, G., Chou, C., Tseng, L., Shen, Y., Yen, J., Huang, S., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.281 · Cited by 2
Mitochondrial disorders due to mutations in the mitochondrial genome
DiMauro, S., & Emmanuele, V. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813955-4.00027-1 · Cited by 2
Reversible cerebral artery constriction accompanied with stroke-like episode in MELAS: A case series
Zhao, Y., Yu, X., Ji, K., Lin, Y., Xu, X., Wang, W., & Yan, C. (2022) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2022.120345 · Cited by 2
Cao, L., Feng, C., Ye, H., Zhao, H., Shi, Z., Li, J., Wu, Y., Wang, R., Li, Q., Liang, J., et al. (2024) · Genomics · doi:10.1016/j.ygeno.2024.110814 · Cited by 2
A Review over Mitochondrial Diseases Due to mtDNA Mutations: Recent Advances and Remedial Aspects
Bharadwaj, A. (2024) · Infectious Disorders - Drug Targets · doi:10.2174/0118715265304029240801092834 · Cited by 2
Knoblauch, K. K. B., Losnack, L. F., Zacarias, G. C., Satyro, G. G., Villar, R., & Zago, A. S. (2025) · Healthcare · doi:10.3390/healthcare13060667 · Cited by 2
Kinoshita, M., Yatsuga, S., Iwata, O., Okamura, H., Morisaki, T., Iwata, S., Hara, N., Shindo, R., Saikusa, M., Harada, E., et al. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.09.002 · Cited by 2
Mitochondrial myopathy without extraocular muscle involvement: a unique clinicopathologic profile
Lin, Y., Wang, J., Ren, H., Ma, X., Wang, W., Zhao, Y., Xu, Z., Liu, S., Wang, W., Xu, X., et al. (2023) · Journal of Neurology · doi:10.1007/s00415-023-12005-5 · Cited by 2
Height as a clinical biomarker of disease burden in adult mitochondrial disease
Boal, R., Ng, Y. S., McFarland, R., & Cheetham, T. D. (2017) · Endocrine Abstracts · doi:10.1530/endoabs.51.p042 · Cited by 2
Isik, F. I., Thomson, S., Cueto, J. F., Spathos, J., Breit, S. N., Tsai, V. W.-W., Brown, D. A., & Finney, C. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.07.600156 · Cited by 2
The Role of Mitokines in Diabetic Nephropathy
Yang, M., Chen, W., He, L., Wang, X., Liu, D., Xiao, L., & Sun, L. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673255403230919061828 · Cited by 1
ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke
Ju, X., Zhang, T., Cui, J., Lee, Y., Lee, S., Kim, H. M., Hong, B., Park, J. H., Choi, C. H., Yi, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202417086 · Cited by 1
GDF15 connecting ageing and cancer: Mechanistic insights and therapeutic opportunities
Lyu, Z., Fan, N., Deng, P., Huang, Q., Bruns, C., & Zhao, Y. (2025) · Ageing and Cancer Research & Treatment · doi:10.70401/acrt.2025.0004 · Cited by 1
Babu, K. S., Gupta, V., Kaur, H., Arunprasad, V. K., Kapil, L., Choudhary, N., & Kumar, D. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01684-z · Cited by 3
Metformin increases glycolysis and the stress-induced cytokine GDF15 but not FGF21 in humans
Kolnes, K. J., Møller, P. M., Kruse, R., Christensen, M. H., Kjøbsted, R., Hey-Mogensen, M., Andersen, B., Handberg, A., & Højlund, K. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1797525 · Cited by 2
Stern, S., Crisamore, K., Patton, J., Schuck, R. N., & Pacanowski, M. A. (2026) · Clinical and Translational Science · doi:10.1111/cts.70634 · Cited by 1
Yıldız, A., Yıldız, M. T., & Önal, H. (2026) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2026.110246 · Cited by 1
Mitochondrial homeodynamics in ageing: mechanisms, resilience, and interventions
Chmielewski, P. P. (2026) · Biogerontology · doi:10.1007/s10522-026-10506-0 · Cited by 2
Les déficits de la chaîne respiratoire : démarche diagnostique des cytopathies mitochondriales
Gaignard, P., Becker, P., Lebigot, É., Thérond, P., & Slama, A. (2018) · Revue Francophone des Laboratoires · doi:10.1016/s1773-035x(18)30118-7 · Cited by 1
Genetics of Mitochondrial Respiratory Chain Disease
Ganetzky, R. D., & Falk, M. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-812535-9.00016-9 · Cited by 1
Wesół‐Kucharska, D., Rokicki, D., Greczan, M., Kaczor, M., Czekuć-Kryśkiewicz, E., Piekutowska‐Abramczuk, D., Halat-Wolska, P., Ciara, E., Jaworski, M., & Jezela‐Stanek, A. (2022) · Pediatric Endocrinology Diabetes and Metabolism · doi:10.5114/pedm.2022.116116 · Cited by 1
Untargeted Metabolomics, Targeted Care: The Clinical Utilities of Bedside Metabolomics
Manor, J., & Elsea, S. H. (2023) · Springer eBooks · doi:10.1007/978-981-99-5162-8_6 · Cited by 1
Hsu, Y.-M., Davis, S. S., Liao, C., Larson, S. R., Nava, V., Wang, J., Miller, D. M., Kennedy, B. K., & Ramanathan, A. (2020) · doi:10.21203/rs.3.rs-39327/v1 · Cited by 1
Wachstumsdifferenzierungsfaktor 15 ist ein hoch spezifischer Biomarker
Reichmann, H. (2016) · InFo Neurologie + Psychiatrie · doi:10.1007/s15005-016-1641-8
Diagnostic des maladies mitochondriales
Jardel, C., & Rucheton, B. (2018) · Revue Francophone des Laboratoires · doi:10.1016/s1773-035x(18)30119-9 · Cited by 5
Diseases of DNA Polymerase Gamma
Hikmat, O., Isohanni, P., Suomalainen, A., & Bindoff, L. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-05517-2_7
WITHDRAWN: This article has been withdrawn
Spiegeleer, A. D., Elewaut, D. S., Noortgate, N. J. V. D., Janssens, Y., Debunne, N., Langenhove, S. V., Govindarajan, S., Spiegeleer, B. M. J. D., & Wynendaele, E. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165585
RetractedThe history and evolving paradigm for genomic diagnosis of mitochondrial diseases
Thorburn, D. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820029-2.00001-2
Mitochondrial dysfunction triggers secretion of the immunosuppressive factor α-fetoproteinPreprint
Jett, K., Baker, Z. N., Hossain, A., Boulet, A., Cobine, P. A., Ghosh, S., Ng, P., Yilmaz, O., Barreto, K., DeCoteau, J. F., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.02.450924
Gizatulina, T. P., Martyanova, L. U., Petelina, T. I., Зуева, Е. В., & Евгеньевич, Ш. Н. (2021) · Journal of Arrhythmology · doi:10.35336/va-2021-e-32-38
株式公開を意識したベンチャー企業のための不祥事防止策に関する一考察 : ガバナンス・モデルを目指して
内田, 亨., & 山本, 靖. (2013)
Treatment and Management of Hereditary Metabolic Myopathies
Vorgerd, M., & Deschauer, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-71317-7.00023-8
Mitochondrial Dysfunction and Growth Differentiation Factor 15 in Aging
Fujita, Y., & Tanaka, M. (2022) · Springer eBooks · doi:10.1007/978-981-16-7977-3_9
GDF15 mediates renal cell plasticity in response to potassium depletionPreprint
Lasaad, S., Walter, C., Rafael, C., Morla, L., Doucet, A., Picard, N., Blanchard, A., Fromes, Y., Matot, B., Crambert, G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.27.521983
A brief introduction to the history of mitochondrial research in Japan
Koga, Y., & Tanaka, M. (2023) · Mitochondrial Communications · doi:10.1016/j.mitoco.2023.02.001
Lyu, J., Lou, X., Chen, Z., Zhao, Q., Zhou, Y., Zeng, X., Ma, X., Luo, P., Zhang, C., Zhang, L., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3389404/v1
Drastic fall of growth differentiation factor 15 in influenza encephalopathy
Sawada, D., Fujii, K., Shiohama, T., Saito, C., Yoshii, S., Hamada, H., & Koga, Y. (2024) · Pediatrics International · doi:10.1111/ped.15768
Mitochondrial disorders due to mutations in the mitochondrial genome
DiMauro, S., & Emmanuele, V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19041-4.00006-6
Mechanisms of Real-Time Cellular Metabolic Analysis
Hayashi, U., Hara, H., & Hirai, S. (2024) · Journal of Nihon University Medical Association · doi:10.4264/numa.83.5_171
Koizumi, M., Ikeda, T., Kimizu, T., Okazaki, Y., Murayama, K., & Etani, Y. (2025) · Pediatrics International · doi:10.1111/ped.70052
Rossi, V. C., Brooks, D., Dai, H., Mizerik, E. A., Salazar, K., Davila‐Williams, D., Moshe, Y. B., Lalani, S. R., Elsea, S. H., Gijavanekar, C., et al. (2025) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.64177
Ozawa, Y., Okamoto, H., Taniyama, Y., Sato, C., Ishida, H., Sato, T., Ohnuma, S., Unno, M., Abe, T., & Kamei, T. (2025) · Esophagus · doi:10.1007/s10388-025-01157-0 · Cited by 1
Rufa, A., Plantone, D., Bargagli, A., Righi, D., Bacci, T., Serchi, V., Primiano, G., Gallus, G. N., Lopergolo, D., Pretegiani, E., et al. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf446
Dyck, L. V., Gunst, J., Casaer, M. P., Peeters, B., Derese, I., Wouters, P. J., de Zegher, F., Vanhorebeek, I., & Van den Berghe, G. (2020) · Figshare · doi:10.6084/m9.figshare.12955871
Dyck, L. V., Gunst, J., Casaer, M. P., Peeters, B., Derese, I., Wouters, P. J., de Zegher, F., Vanhorebeek, I., & Van den Berghe, G. (2020) · Figshare · doi:10.6084/m9.figshare.12955868
Yang, J., Liu, L., Oda, Y., Wada, K., Ago, M., Matsuda, S., Hattori, M., Goto, T., Kawashima, Y., Matsuzaki, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22620631
Context-Specific Hypermetabolism In Humans With Mitochondrial Energy Transformation DefectsPreprint
Shaulson, E. D., Sercel, A. J., Rausser, S., Leonard, S. J., Whyte, K., Zuraikat, F. M., Seid, H., Huang, Q., Junker, A., Kapri, D., et al. (2026) · medRxiv · doi:10.64898/2026.05.30.26354528
Griffo, M., Magri, F., Furlan, F., Bernardi, E., Menni, F., Tagliaferri, F., Testa, S., Ronchi, D., Petrillo, S., Piemonte, F., et al. (2026) · BMC Neurology · doi:10.1186/s12883-026-05041-x
Hu, J., Liufu, T., Li, C., Zhao, Q., Yu, M., Yuan, Y., Quan, L., Chen, Z., & Wang, Z. (2026) · Clinica Chimica Acta · doi:10.1016/j.cca.2026.121172
Fukuda, T., Kondo, K., Nishikawa, R., Hirai, R., Ishizaka, H., Tan, H., Nozawa, N., Tokoi, S., Hirose, S., Yamaguchi, S., et al. (2026) · Journal of Nutrition and Metabolism · doi:10.1155/jnme/3379141 · Cited by 1
Leung, H.-K., Tan, G.-J., Wong, W., Khamis, F., Zain, S. M., & Chan, W. (2026) · Hepatoma Research · doi:10.20517/2394-5079.2026.20
Exploration of brain energy demand and neuronal aging: implications for tauopathies, neuroprotection
Ávila, J., & Hernández, F. (2026) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2026.1004166
Santis, S. D., Rutigliano, M., Simone, F., Larocca, L., Matrella, M. L., Milella, M., Vavallo, A., Ditonno, P., Marrano, N., Mestice, A., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117230
Hida, M., Suda, K., Fujimoto, T., Goto, H., Watayo, H., Tsunoda, Y., Shimizu, M., Iwakami, T., Nakano, S., Suzuki, M., et al. (2026) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2026.163415
Mitochonic acid 5 alleviates amyotrophic lateral sclerosis phenotypes via mitochondrial augmentation
Oikawa, Y., Luo, Y., Suzuki, N., Kasahara, T., Tongu, Y., Yoshida, Y., Tominari, T., Tanabe, S., Suto, Y., Kashiwagi, H., et al. (2026) · JCI Insight · doi:10.1172/jci.insight.200761
Relative energy deficiency in sport (REDs) as a stress-induced disruption of energy flow
Balagué, N., Lizarraga, M. A., & Montull, L. (2026) · Apunts Sports Medicine · doi:10.1016/j.apunsm.2026.100535
Masuda, T., Ataka, T., Sumi, K., Takeuchi, Y., Akiyoshi, Y., Matsuzaki, F., Hirakawa, H., Matsubara, E., & Kimura, N. (2026) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2026.100991
Sumi, K., Masuda, T., Mochizuki, S., Kondo, H., Takahashi, N., & Kimura, N. (2026) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2026.126199
Cellular senescence in multiple sclerosis: hallmarks, immunosenescence, and therapeutic implications
Yousef, A., Seubert, J. M., Power, C., & Nathoo, N. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1944657
Context-specific hypermetabolism in humans with mitochondrial defects
Shaulson, E. D., Sercel, A. J., Rausser, S., Leonard, S., Whyte, K., Zuraikat, F. M., Seid, H., Huang, Q., Junker, A., Kapri, D., et al. (2026) · Cell Press Blue · doi:10.1016/j.cpblue.2026.100129
Mitochondrial dysfunction in neurology: biomarkers and clinical implications
Rossini, E., Garibaldi, M., Hanna, M. G., Pitceathly, R. D. S., & Pizzamiglio, C. (2026) · Nature Reviews Neurology · doi:10.1038/s41582-026-01274-z
Metadata
- Authors
- Yatsuga, S., Fujita, Y., Ishii, A., Fukumoto, Y., Arahata, H., Kakuma, T., Kojima, T., Ito, M., Tanaka, M., Saiki, R., & Koga, Y.
- Affiliations
- Kurume University (JP)
- Tokyo Metropolitan Institute of Gerontology (JP)
- University of Tsukuba (JP)
- Omuta hospital (JP)
- Toyohashi University of Technology (JP)
- Corresponding author
- Koga, Yasutoshi
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2015-10-14
- Volume
- 78
- Issue
- 5
- Pages
- 814-823
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC5057301
- OpenAlex
- W1903699046
- Cited by
- 293
- References
- 25
- Citations by year
- 2026: 26 · 2025: 29 · 2024: 29 · 2023: 24 · 2022: 32 · 2021: 35 · 2020: 41 · 2019: 31 · 2018: 14 · 2017: 18 · 2016: 13
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Annals of Neurology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (publishedVersion)
- Terrestrial Environment Research Center (University of Tsukuba) (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) (25461571 (to Y.K.), 25860891 (to S.Y.), 25242062 (to M.T.))
- The Ministry of Health, Labor and Welfare of Japan. (24-Nanchi-Ippan-005 (to Y.K.) for Research on Intractable Diseases)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › GDF15 and Related Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- growth differentiation factor 15, mitochondrial disease, biomarkers, FGF21, respiratory chain deficiency, serum biomarkers, disease severity, sensitivity and specificity
- MeSH terms
- Adolescent, Adult, Child, Creatine Kinase, Female, Fibroblast Growth Factors, Humans, Male, Middle Aged, ROC Curve, Biomarkers, MELAS Syndrome, Pyruvic Acid, Lactic Acid, Mitochondrial Diseases, Growth Differentiation Factor 15, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
