The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.
Predicting recovery in acute poststroke aphasia
Open accessAbstract
Objective: Many stroke patients show remarkable recovery of language after initial severe impairment, but it is difficult to predict which patients will show good recovery. We aimed to identify patient and lesion characteristics that together predict the best naming outcome in 4 studies. Methods: We report 2 longitudinal studies that identified 2 variables at onset that were strongly associated with good recovery of naming (the most common residual deficit in aphasia) in the first 6 months after stroke: damage to left posterior superior temporal gyrus (pSTG) and/or superior longitudinal fasciculus/arcuate fasciculus (SLF/AF), and selective serotonin reuptake inhibitor (SSRI) use. We then tested these variables in 2 independent cohorts of chronic left hemisphere stroke patients, using chi‐square tests and multivariate logistic regression for dichotomous outcomes and t tests for continuous outcomes. Results: Lesion load in left pSTG and SLF/AF was associated with poorer naming outcome. Preservation of these areas and use of SSRIs were associated with naming recovery, independent of lesion volume, time since stroke, and depression. Patients with damage to these critical areas showed better naming outcome if they took SSRIs for 3 months after stroke. Those with preservation of these critical areas achieved good recovery of naming regardless of SSRI use. Interpretation: Lesion load in left pSTG and SLF/AF at onset predicts later naming performance. Although based on a small number of patients, our preliminary results suggest outcome might be modulated by SSRIs, but these associations need to be confirmed in a larger randomized controlled trial. Ann Neurol 2018;83:612–622
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“Hillis et al. [38] recently demonstrated that the influence of lesion load on aphasia recovery may be influenced by SSRIs. For patients with superior temporal and/or SLF/AF lesions, the use of SSRIs improved naming outcomes, independent of the presence of depression, initial aphasia severity, or lesion volume.”
From Aphasia Recovery: When, How and Who to Treat? (2018) · cites this paper as [38]
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Cites
Ashburner, J., & Friston, K. J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.018 · Cited by 7,507
Plasticity during stroke recovery: from synapse to behaviour
Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938 · cited 1×
“SSRIs increase brain-derived neurotrophic factor,(15) which may be a critical modulator of recovery.(16) These mechanisms might account for the positive effect of an SSRI on human motor recovery(17) and cognitive performance.”
BackgroundLöwe, B., Kroenke, K., Herzog, W., & Gräfe, K. (2004) · Journal of Affective Disorders · doi:10.1016/s0165-0327(03)00198-8 · Cited by 1,558 · cited 1×
“Depression Assessment In both the longitudinal study and the cross-sectional study that evaluated the effect of antidepressants, we also evaluated for depression using the Patient Health Questionnaire-9 (PHQ-9).(28) In a study of 200 stroke patients within 1 month of onset, a score of 10 on the PHQ-9 had 91% sensitivi…”
MethodWestern Aphasia Battery--Revised
Kertesz, A. (2012) · PsycTESTS Dataset · doi:10.1037/t15168-000 · Cited by 1,367
Makris, N., Kennedy, D. N., McInerney, S., Sorensen, A. G., Wang, R., Caviness, V. S., & Pandya, D. N. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhh186 · Cited by 1,146 · cited 2×
“It includes all 3 subcomponents of the AF described by Markris et al.(36) There was a significant correlation between expected recovery (70% of maximal recovery) and observed recovery (r(2) 5 0.”
BackgroundInfluentialChollet, F., Tardy, J., Albucher, J.-F., Thalamas, C., Berard, E., Lamy, C., Bejot, Y., Deltour, S., Jaillard, A., Niclot, P., et al. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70314-8 · Cited by 925 · cited 1×
“There may be several positive effects of SSRIs after stroke; the effects on mood (as assessed by this screening test) and language recovery appear to be relatively independent.(17,47) Limitations of our research include that we did not evaluate the effects of SSRIs at different time periods after stroke or the influen…”
BackgroundAphasia in acute stroke: Incidence, determinants, and recovery
Pedersen, P. M., Jørgensen, H. S., Nakayama, H., Raaschou, H. O., & Olsen, T. S. (1995) · Annals of Neurology · doi:10.1002/ana.410380416 · Cited by 823
Interaction between BDNF and Serotonin: Role in Mood Disorders
Martinowich, K., & Lu, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301571 · Cited by 793
Age-specific CT and MRI templates for spatial normalization
Rorden, C., Bonilha, L., Fridriksson, J., Bender, B., & Karnath, H. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.020 · Cited by 753 · cited 1×
“For acute patients, the normalization transforms were computed for the DWI B 5 0 image (which does not yet show stroke-related abnormalities) to a template based on age-matched controls.(30) The normalization parameters were then applied to the DWI tracebased lesion.”
MethodSelf-citationEngelter, S. T., Gostynski, M., Papa, S., Frei, M., Born, C., Ajdacic-Gross, V., Gutzwiller, F., & Lyrer, P. A. (2006) · Stroke · doi:10.1161/01.str.0000221815.64093.8c · Cited by 688
Flagged first, then by citations
1 of the 47 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Goodglass H, 2000, Boston disagnostic aphasia examination
- Kaplan E, 2001, Boston naming test
- Cohen J, 1988, Statistical power analyses for the social sciences
Cited by
Sorted by citations
Neuroplasticity of Language Networks in Aphasia: Advances, Updates, and Future Challenges
Kiran, S., & Thompson, C. K. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00295 · Cited by 250
“Likewise, with respect to language recovery, Hillis found that damage to left posterior superior temporal gyrus and fibers that included superior longitudinal fasciculus and arcuate fasciculus negatively influenced the degree of recovery of naming skills (33) in acute and chronic patients with aphasia, and these findi…”
BackgroundThe neural and neurocomputational bases of recovery from post-stroke aphasia
Stefaniak, J. D., Halai, A. D., & Ralph, M. A. L. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0282-1 · Cited by 176
Current Approaches to the Treatment of Post-Stroke Aphasia
Fridriksson, J., & Hillis, A. E. (2021) · Journal of Stroke · doi:10.5853/jos.2020.05015 · Cited by 172
“Other factors have also been implicated such as the degree of damage to posterior superior temporal gyrus or arcuate fasciculus,(46,47) independently of lesion volume, and recovery in patients with damage to these critical areas may be influenced by medications.(46) Aphasia severity, a factor related to overall lesion…”
BackgroundSelf-citationRecovery from aphasia in the first year after stroke
Wilson, S. M., Entrup, J. L., Schneck, S. M., Onuscheck, C. F., Levy, D. F., Rahman, M., Willey, E., Casilio, M., Yen, M., Brito, A. C., et al. (2022) · Brain · doi:10.1093/brain/awac129 · Cited by 163
Diagnosing and managing post-stroke aphasia
Sheppard, S. M., & Sebastian, R. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1855976 · Cited by 166
Self-citation
Metadata
- Authors
- Hillis, A. E., Beh, Y. Y., Sebastian, R., Breining, B., Tippett, D. C., Wright, A., Saxena, S., Rorden, C., Bonilha, L., Basilakos, A., Yourganov, G., & Fridriksson, J.
- Affiliations
- Johns Hopkins University (US)
- Medical University of South Carolina (US)
- University of South Carolina (US)
- Corresponding author
- Hillis, Argye E.
- Beh, Yuan Ye
- Sebastian, Rajani
- Breining, Bonnie
- Tippett, Donna C.
- Wright, Amy
- Saxena, Sadhvi
- Rorden, Chris
- Bonilha, Leonardo
- Basilakos, Alexandra
- Yourganov, Grigori
- Fridriksson, Julius
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2018-03
- Volume
- 83
- Issue
- 3
- Pages
- 612-622
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC5867273
- OpenAlex
- W2791952209
- Cited by
- 142
- References
- 47
- Citations by year
- 2026: 17 · 2025: 8 · 2024: 21 · 2023: 19 · 2022: 21 · 2021: 15 · 2020: 15 · 2019: 21 · 2018: 4
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01 DC05375, T32 DC014435, P50 DC014664)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Keywords
- post-stroke aphasia, posterior superior temporal gyrus, superior longitudinal fasciculus, arcuate fasciculus, selective serotonin reuptake inhibitors, lesion load, left hemisphere stroke, chronic stroke
- MeSH terms
- Acute Disease, Adult, Aged, Aphasia, Brain Mapping, Female, Humans, Functional Laterality, Male, Middle Aged, Neural Pathways, Recovery of Function, Stroke, Cerebrum, Diffusion Tensor Imaging
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