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Cited by 688Acute Ischemic Stroke ManagementNeurobiology of Language and BilingualismDementia and Cognitive Impairment Research

Epidemiology of Aphasia Attributable to First Ischemic Stroke: Incidence, Severity, Fluency, Etiology, and Thrombolysis

Engelter, Stefan T., Gostynski, Michal, Papa, Susanna, Frei, Maya, Born, Claudia, Ajdacic-Gross, Vladeta, Gutzwiller, Felix, Lyrer, Phillipe A.·2006·Stroke
DOI 10.1161/01.str.0000221815.64093.8c
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Abstract

Background and Purpose— In a geographically defined population, we assessed incidence and determinants of aphasia attributable to first-ever ischemic stroke (FEIS). MethodsA 1-year prospective, population-based study among the permanent residents of the canton Basle City, Switzerland, was performed using multiple overlapping sources of information. Results— Among 188 015 inhabitants, 269 patients had FEIS, of whom 80 (30%; 95% CI, 24 to 36) had aphasia. The overall incidence rate of aphasia attributable to FEIS amounted to 43 per 100 000 inhabitants (95% CI, 33 to 52). Aphasic stroke patients were older than nonaphasic patients. The risk of aphasia attributable to FEIS increased by 4% (95% CI, 1% to 7%), and after controlling for atrial fibrillation, by 3% (95% CI, 1% to 7%) with each year of patients’ age. Gender had no effect on incidence, severity, or fluency of aphasia. Cardioembolism was more frequent in aphasic stroke patients than in nonaphasic ones (odds ratio [OR], 1.85; 95% CI, 1.07 to 3.20). Aphasic patients sought medical help earlier than nonaphasic stroke patients. Still, after controlling for stroke onset–assessment interval, aphasic stroke patients were more likely to receive thrombolysis than nonaphasics (OR, 3.5; 95% CI, 1.12 to 10.96). Conclusion— Annually, 43 of 100 000 inhabitants had aphasia resulting from first ischemic stroke. Advancing age and cardioembolism were associated with an increased risk for aphasia. Severity and fluency of aphasia were not affected by demographic variables.

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Research works printed but not linked: 34

  1. Laska AC, Hellblom A, Murray V, Kahan T, Von Arbin M. Aphasia in acute stroke and relation to outcome. J Intern Med. 2001;249:413-422.
  2. Tilling K, Sterne JA, Rudd AG. A new method for predicting recovery after stroke. Stroke. 2001;32:2867-2873.
  3. Paolucci S, Antonucci G, Pratesi L, Traballesi M, Lubich S, Grasso MG. Functional outcome in stroke inpatient rehabilitation: predicting no, low and high response patients. Cerebrovasc Dis. 1998;8:228 -234.
  4. Black-Schaffer RM, Osberg JS. Return to work after stroke: development of a predictive model. Arch Phys Med Rehabil. 1990;71:285-290.
  5. Bhogal SK, Teasell R, Speechley M. Intensity of aphasia therapy, impact on recovery. Stroke. 2003;34:987-993.
  6. Pedersen PM, Jorgensen HS, Nakayama H, Raaschou HO, Olsen TS. Aphasia in acute stroke: incidence, determinants, and recovery. Ann Neurol. 1995;38:659 -666.
  7. Wade DT, Hewer RL, David RM. Aphasia after stroke: natural history and associated deficits. J Neurol Neurosurg Psychiatry. 1986;49:11-16.
  8. Kauhanen ML, Korpelainen JT, Hiltunen P, Maatta R, Mononen H, Brusin E, Sotaniemi KA, Myllyla VV. Aphasia, depression, and non- verbal cognitive impairment in ischaemic stroke. Cerebrovasc Dis. 2000; 10:455-461.
  9. Brust JC, Shafer SQ, Richter RW, Bruun B. Aphasia in acute stroke. Stroke. 1976;7:167-174.
  10. Siirtola M, Narva EV, Siirtola T. On the occurrence and prognosis of aphasia in patients with cerebral infarction. Scand J Soc Med Suppl. 1977;14:128 -133.
  11. Eslinger PJ, Damasio AR. Age and type of aphasia in patients with stroke. J Neurol Neurosurg Psychiatry. 1981;44:377-381.
  12. Godefroy O, Dubois C, Debachy B. Vascular aphasias: main character- istics of patients hospitalized in acute stroke units. Stroke. 2002;33: 702-705.
  13. Ferro JM, Madureira S. Aphasia type, age and cerebral infarct local- ization. J Neurol. 1997;244:505-509.
  14. Brocklehurst JC, Andrews K, Morris P, Richards BR, Laycock PL. Why admit stroke patients to hospital? Age Ageing. 1978;7:100 -108.
  15. Sudlow CL, Warlow CP. Comparing stroke incidence worldwide: what makes studies comparable? Stroke. 1996;27:550 -558.
  16. Hier DB, Yoon WB, Mohr JP. Gender and aphasia in the Stroke Data Bank. Brain Lang. 1994;47:155-167.
  17. Basso A, Capitani E, Laiacona M, Luzzatti C. Factors influencing type and severity of aphasia. Cortex. 1980;16:631-636.
  18. Basso A, Bracchi M, Capitani E. Age and evolution of language area functions. A study on adult stroke patients. Cortex. 1987;23:475-483.
  19. Scarpa M, Colombo A, Sorgato P, De Renzi E. The incidence of aphasia and global aphasia in left brain-damaged patients. Cortex. 1987;23: 331-336.
  20. Habib M, Ali-Cherif A, Poncet M, Salamon G. Age-related changes in aphasia type and stroke location. Brain Lang. 1987;31:245-251.
  21. Kertesz A, Sheppard A. The epidemiology of aphasic and cognitive impairment in stroke: age, sex, aphasia type and laterality differences. Brain. 1981;104:117-128.
  22. Knepper LE, Biller J, Tranel D. Etiology of stroke in patients with Wernicke's aphasia. Stroke. 1989;20:1730 -1732.
  23. Legatt AD, Rubin MJ, Kaplan LR. Global aphasia without hemiparesis: multiple etiologies. Neurology. 1987;37:201-205.
  24. Gostynski M, Engelter S, Papa S, Ajdacic-Gross V, Gutzwiller F, Lyrer P. Incidence of first-ever ischemic stroke in the Canton Basle-City, Switzerland: a population-based study 2002/2003. J Neurol. 2006; 253:86 -91
  25. Kirshner H. Language disorders. Aphasia. In: Bradley W, Daroff R, Fenichel G, Marsden C, eds. Neurology in Clinical Practice. Boston, Mass/Oxford, UK: Butterworth-Heinemann; 1995:133-147.
  26. Lyden P, Brott T, Tilley B, Welch KM, Mascha EJ, Levine S, Haley EC, Grotta J, Marler J. Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group. Stroke. 1994;25: 2220 -2226.
  27. Schuell H. Minnesota Test for the differential diagnosis of aphasia MTDDA. Minneapolis, Minn: University of Minnesota Press; 1973.
  28. Scandinavian. Multicenter trial of hemodilution in ischemic stroke- background and study protocol. Scandinavian Stroke Study Group. Stroke. 1985;16:885-890.
  29. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE III. Classification of subtype of acute ischemic stroke. Defi- nitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24:35-41.
  30. Di Carlo A, Lamassa M, Pracucci G, Basile AM, Trefoloni G, Vanni P, Wolfe CD, Tilling K, Ebrahim S, Inzitari D. Stroke in the very old: clinical presentation and determinants of 3-month functional outcome: a European perspective. European BIOMED Study of Stroke Care Group. Stroke. 1999;30:2313-2319.
  31. Bhalla A, Grieve R, Tilling K. Older stroke patients in Europe: stroke care and determinants of outcome. Age Ageing. 2004;33:618 -624.
  32. De Renzi E, Faglioni P, Ferrari P. The influence of sex and age on the incidence and type of aphasia. Cortex. 1980;16:627-630.
  33. Di Carlo A, Lamassa M, Baldereschi M, Pracucci G, Basile AM, Wolfe CD, Giroud M, Rudd A, Ghetti A, Inzitari D; European BIOMED Study of Stroke Care Group. Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: data from a multicenter multinational hospital-based registry. Stroke. 2003;34: 1114 -1119.
  34. Di Legge S, Fang J, Saposnik G. The impact of lesion side on acute stroke treatment. Neurology. 2005;65:81-86.

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Authors
Engelter, S. T., Gostynski, M., Papa, S., Frei, M., Born, C., Ajdacic-Gross, V., Gutzwiller, F., & Lyrer, P. A.
Affiliations
  • University of Basel (CH)
  • From the Neurological Clinic and Stroke Unit (S.T.E., S.P., P.A.L.), University Hospital Basle, Switzerland; Institute of Social and Preventive Medicine (M.G., V.A.-G., F.G.), University of Zurich, Switzerland; Institute of Speech Therapy (M.F.), University Hospital Basel, Switzerland; and Institute for Specific Pedagogics and Psychology (C.B.), Basel, Switzerland.
ORCID
Engelter, Stefan T.
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-06
Volume
37
Issue
6
Pages
1379-1384
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.0000221815.64093.8c
OpenAlex
W2142499410
Cited by
688
References
2
Citations by year
2026: 48 · 2025: 43 · 2024: 38 · 2023: 43 · 2022: 53 · 2021: 55 · 2020: 56 · 2019: 56 · 2018: 36 · 2017: 39 · 2016: 39 · 2015: 33 · 2014: 32 · 2013: 33 · 2012: 22
FWCI
6.13
Type
journal article
Language
en
Open access
closed
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
aphasia, stroke incidence, cardiac embolism, atrial fibrillation, age, thrombolysis, stroke severity
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Aphasia, Coronary Vessels, Embolism, Female, Humans, Male, Middle Aged, Prospective Studies, Severity of Illness Index, Thrombolytic Therapy, Incidence, Age Distribution, Sex Distribution, Stroke

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