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Cited by 122Ion channel regulation and functionPotassium and Related DisordersIon Transport and Channel Regulation

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Periodic paralysis and the sodium‐potassium pump

Layzer, Robert B.·1982·Annals of Neurology
DOI 10.1002/ana.410110602
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Abstract

Analysis of the pathophysiology of hypokalemic paralysis, as it occurs in barium poisoning, chronic potassium deficiency, and thyrotoxicosis, suggests that these disorders may have a similar mechanism. An increased ratio of muscle sodium permeability to potassium permeability reduces the ionic diffusion potential, while the resting membrane potential is sustained by an increase of Na‐K pump electrogenesis. The result is that potassium entry (the sum of active and passive influx) exceeds potassium efflux; this causes a large shift of extracellular potassium into muscle until the Na‐K pump turns off, leading to depolarization and paralysis. The primary defect in familial hypokalemic periodic paralysis, as in the example of barium poisoning, may be a marked reduction of muscle permeability to potassium.

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Crossref · 10.1002/ana.410110602

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37 of 37 references verified0 citation errors · 0 not checkable

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Citations

Cites

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Research works printed but not linked: 2

  1. Riecker G, 1964, Hypokaliämie und Membranpotential. Mikropunktionen einzelner Muskelzellen beim Menschen, Reanim Org Artif, 1, 41
  2. Smith SG, 1950, Potassium deficiency syndrome in the rat and the dog, Arch Pathol, 49, 185

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Metadata

Authors
Layzer, R. B.
Affiliations
University of California, San Francisco (US)
Corresponding author
Layzer, Robert B.
Venue
Annals of Neurology
Publisher
Wiley
Published
1982-06
Volume
11
Issue
6
Pages
547-552
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.410110602
OpenAlex
W2133203459
Cited by
122
References
37
Citations by year
2026: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 7
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8164 d)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Health Sciences › Medicine › Nephrology › Potassium and Related Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
periodic paralysis, hypokalemic paralysis, Na+/K+-ATPase, barium poisoning, thyrotoxicosis, resting membrane potential, depolarization, potassium shift, familial hypokalemic periodic paralysis
MeSH terms
Animals, Anura, Barium, Chronic Disease, Dogs, Humans, Hyperthyroidism, Ion Channels, Paralysis, Periodicity, Potassium Deficiency, Rats

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