THE ASSOCIATION OF PERIODIC PARALYSIS AND HYPERTHYROIDISM IN JAPAN

OKINAKA, SHIGEO; SHIZUME, KAZUO; UNO, SHIRO; WATANABE, AKIRA; IRIE, MINORU; NOGUCHI, AKITO; KUMA, SHIZUO; KUMA, KANJI; ITO, TADASU

doi:10.1210/jcem-17-12-1454

Cited by 207Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryPotassium and Related Disorders

THE ASSOCIATION OF PERIODIC PARALYSIS AND HYPERTHYROIDISM IN JAPAN

OKINAKA, SHIGEO, SHIZUME, KAZUO, UNO, SHIRO, WATANABE, AKIRA, IRIE, MINORU, NOGUCHI, AKITO, KUMA, SHIZUO, KUMA, KANJI +1 more·1957·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-17-12-1454

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Abstract

ALTHOUGH periodic paralysis is a rare disorder, its association with hyperthyroidism has been reported by several investigators (1–15). In reviewing the literature, it was found that only about 30 such cases have been reported from the United States and Europe, whereas more than 70 cases have been reported from Japan. Possibly the association of these two disorders is less rare in Japan. As the Japanese reports were all concerned with relatively small numbers of patients with hyperthyroidism, the incidence of the association of these two disorders in Japan could not be estimated. In order to obtain a fairly good estimate, the incidence of periodic paralysis among 6,333 cases of hyperthyroidism operated upon in three thyroid hospitals in Japan was studied. These hospitals were located in different parts of country—Noguchi Hospital in Beppu, Kyushu (southern part of Japan), Kuma Hospital in Kobe (central part of Japan) and Ito Hospital in Tokyo (eastern part of Japan), so the study provided data on a cross section of Japanese patient populations.

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Thyrotoxic periodic paralysis (TPP) is a disorder most commonly seen in Asian men.
“Thyrotoxic periodic paralysis (TPP), a disorder most commonly seen in Asian men, is characterized by abrupt onset of hypokalemia and paralysis.”
From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [2]
The incidence of TPP in Japanese thyrotoxic patients is 1.9%.
“The incidence of TPP in Chinese and Japanese thyrotoxic patients has been reported at 1.8% and 1.9%, respectively [2], whereas in North Americans at 0.1%–0.2% [5].”
From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [2]
The incidence of TPP in Chinese thyrotoxic patients is 1.8%.
“The incidence of TPP in Chinese and Japanese thyrotoxic patients has been reported at 1.8% and 1.9%, respectively [2], whereas in North Americans at 0.1%–0.2% [5].”
From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [2]
TPP is more commonly reported in oriental Asians.
“Thyrotoxic periodic paralysis (TPP) is more commonly reported in oriental Asians [2].”
From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [2]

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THYROTOXICOSIS AND RENAL TUBULAR ACIDOSIS PRESENTING AS HYPOKALAEMIC PARALYSIS
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Background

Authors: OKINAKA, S., SHIZUME, K., UNO, S., WATANABE, A., IRIE, M., NOGUCHI, A., KUMA, S., KUMA, K., & ITO, T.
Affiliations: Ito Hospital (JP)
ORCID: WATANABE, AKIRA
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1957-12
Volume: 17
Issue: 12
Pages: 1454-1459
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-17-12-1454
OpenAlex: W2087117762
Cited by: 206
References: 0
Citations by year: 2025: 5 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 7
FWCI: 1.55
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
Keywords: periodic paralysis, hyperthyroidism, hypokalemic periodic paralysis, thyrotoxic periodic paralysis, incidence, Japanese patients
MeSH terms: Humans, Hyperthyroidism, Japan, Paralysis

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THE ASSOCIATION OF PERIODIC PARALYSIS AND HYPERTHYROIDISM IN JAPAN

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