The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Dendritic atrophy in children with down’s syndrome.
Abstract
Dendritic branching was evaluated in the visual cortex of 8 children with Down's syndrome and 10 controls, ranging in age from 4 months to 7 years and divided into infantile, late-infantile, and juvenile groups. Camera lucida drawings of Golgi-impregnated neurons were used for examining the following dendritic aspects: dendritic intersections as a function of distance from the cell body, point of maximum dendritic branching, number of branch orders, total number of branch segments, and total dendritic length. The number of intersections and the total dendritic length were above normal in the infantile period (6 months old or less) and dropped steadily to significantly below normal in the juvenile group (older than 2 years). These reductions contrasted with expanding dendritic arborization in normal children. The results suggest that the dendritic tree atrophies in early childhood in Down's syndrome.
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In the citing paper
“Initially, in infants aged 0–6 months, the total dendritic length was longer in samples from individuals with DS compared to controls.”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Becker et al., 1986
In the citing paper
“However, as development continued this difference reversed, with dendritic length becoming significantly shorter in samples from individuals with DS and persisting at least into childhood (7 years) (Becker et al., 1986).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Becker et al., 1986
In the citing paper
“However, the human equivalent age of the engrafted neurons (5–8 months) during this time period is comparable to the samples that show an increase spine number in human tissue (Becker et al., 1986).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Becker et al., 1986
Citations
Cites
Pattern Discrimination and the Visual Cortex
Sholl, D. A., & Uttley, A. M. (1953) · Nature · doi:10.1038/171387a0 · Cited by 605
Pattern of dendritic branching in occipital cortex of rats reared in complex environments
Greenough, W. T., & Volkmar, F. R. (1973) · Experimental Neurology · doi:10.1016/0014-4886(73)90090-3 · Cited by 536
Dendritic Growth in the Aged Human Brain and Failure of Growth in Senile Dementia
Buell, S. J., & Coleman, P. D. (1979) · Science · doi:10.1126/science.493989 · Cited by 475
Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice
RAKIC, P. T., & Sidman, R. L. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901520203 · Cited by 467
Takashima, S., Becker, L. E., Armstrong, D. L., & Chan, F. (1981) · Brain Research · doi:10.1016/0006-8993(81)90314-0 · Cited by 307
Self-citationPyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study
Marin‐Padilla, M. (1976) · Journal of Comparative Neurology · doi:10.1002/cne.901670105 · Cited by 285
Buell, S. J., & Coleman, P. D. (1981) · Brain Research · doi:10.1016/0006-8993(81)90436-4 · Cited by 220
Down's syndrome: Is there a decreased population of neurons?
Ross, M. H., Galaburda, A. M., & Kemper, T. L. (1984) · Neurology · doi:10.1212/wnl.34.7.909 · Cited by 191
Suetsugu, M., & Mehraein, P. (1980) · Acta Neuropathologica · doi:10.1007/bf00688755 · Cited by 190
Cupp, C. J., & Uemura, E. (1980) · Experimental Neurology · doi:10.1016/0014-4886(80)90150-8 · Cited by 155
Research works printed but not linked: 2
- Coleman PD, 1968, Environmental effects on cortical dendritic fields. I. Rearing in the dark, J Anat (Lond), 102, 363
- Kurnit DM, 1980, A molecular approach to Down's syndrome, Down's syndrome, 3, 1
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Kolb, B. E., & Whishaw, I. Q. (1998) · Annual Review of Psychology · doi:10.1146/annurev.psych.49.1.43 · Cited by 822
Dendritic Anomalies in Disorders Associated with Mental Retardation
Kaufmann, W. E. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.981 · Cited by 746
Dendritic Spine Structural Anomalies in Fragile-X Mental Retardation Syndrome
Irwin, S. A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.1038 · Cited by 626
Serotonin and brain development: role in human developmental diseases
Whitaker-Azmitia, P. M. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00615-3 · Cited by 506
Wayman, G. A., Impey, S., Marks, D., Saneyoshi, T., Grant, W. F., Derkach, V., & Soderling, T. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.008 · Cited by 466
Metadata
- Authors
- Becker, L. E., Armstrong, D. L., & Chan, F.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Becker, L. E.
- ORCID
- Becker, L. E.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1986-10
- Volume
- 20
- Issue
- 4
- Pages
- 520-526
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2137900611
- Cited by
- 279
- References
- 25
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 14 · 2012: 16
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
- Keywords
- Down syndrome, dendritic atrophy, dendritic branching, visual cortex, dendritic length, children
- MeSH terms
- Child, Preschool, Dendrites, Down Syndrome, Humans, Infant, Visual Cortex
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