Dendritic arborization in the human fetus and infant with the trisomy 18 syndrome
Abstract
Dendritic arborization patterns of visual cortical neurons in four cases of trisomy 18 syndrome were compared with those in 8 neurologically asymptomatic age-matched controls. The trisomy cases included a 20-week-old fetus, a term infant, a 3-month-old infant, and 6-month-old infant. Quantitative Golgi analysis showed a decrease in the mean total dendritic length of apical dendrites in layer 5 pyramidal neurons in the term infant with trisomy 18. In layer 3, an attenuated dendritic tree was observed in the earlier age groups with increased dendritic extent at 6 months. Although not conclusive, due to the small number of subjects, this preliminary study showed definitive dendritic abnormalities in the trisomy 18 syndrome.
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In all human chromosomal aberration syndromes, including trisomies, monosomies, polyploidies, disomies and imprinting errors or sex chromosome anomalies, structural abnormalities of (pre)frontal as well as many other areas are common.
“In all human chromosomal aberration syndromes, including trisomies, monosomies (e.g., Turner syndrome, monosomy 1p36), polyploidies, disomies and imprinting errors or sex chromosome anomalies, structural abnormalities of (pre)frontal as well as many other areas are common [61, 288–292].”
From Development of prefrontal cortex (2022) · cites this paper as [291]
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Development of prefrontal cortex
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A human neurodevelopmental model for Williams syndrome
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- Authors
- Jay, V., Chan, F.-W., & Becker, L. E.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Becker, Laurence E.
- Venue
- Developmental Brain Research
- Publisher
- Elsevier BV
- Published
- 1990-07
- Volume
- 54
- Issue
- 2
- Pages
- 291-294
- ISSN
- 0165-3806 (ISSN-L)
- OpenAlex
- W2094196257
- Cited by
- 10
- References
- 19
- Citations by year
- 2021: 2 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- trisomy 18, trisomy 13, dendritic branching, dendritic length, visual cortex, pyramidal neurons, layer 5, layer 3, human fetus, infant brain development, Golgi staining
- MeSH terms
- Chromosomes, Human, Pair 18, Dendrites, Fetus, Humans, Syndrome, Trisomy, Visual Cortex
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