Cited by 279Down syndrome and intellectual disability researchGenetics and Neurodevelopmental DisordersWilliams Syndrome Research

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Dendritic atrophy in children with down’s syndrome.

Becker, L. E., Armstrong, D. L., Chan, F.·1986·Annals of Neurology

DOI 10.1002/ana.410200413

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Abstract

Dendritic branching was evaluated in the visual cortex of 8 children with Down's syndrome and 10 controls, ranging in age from 4 months to 7 years and divided into infantile, late-infantile, and juvenile groups. Camera lucida drawings of Golgi-impregnated neurons were used for examining the following dendritic aspects: dendritic intersections as a function of distance from the cell body, point of maximum dendritic branching, number of branch orders, total number of branch segments, and total dendritic length. The number of intersections and the total dendritic length were above normal in the infantile period (6 months old or less) and dropped steadily to significantly below normal in the juvenile group (older than 2 years). These reductions contrasted with expanding dendritic arborization in normal children. The results suggest that the dendritic tree atrophies in early childhood in Down's syndrome.

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Authors: Becker, L. E., Armstrong, D. L., & Chan, F.
Affiliations: University of Toronto (CA)
Corresponding author: Becker, L. E.
ORCID: Becker, L. E.
Venue: Annals of Neurology
Publisher: Wiley
Published: 1986-10
Volume: 20
Issue: 4
Pages: 520-526
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.410200413
OpenAlex: W2137900611
Cited by: 279
References: 25
Citations by year: 2026: 1 · 2025: 10 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 14 · 2012: 16
FWCI: 5.85
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6582 d)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
Keywords: Down syndrome, dendritic atrophy, dendritic branching, visual cortex, dendritic length, children
MeSH terms: Child, Preschool, Dendrites, Down Syndrome, Humans, Infant, Visual Cortex

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Dendritic atrophy in children with down’s syndrome.

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