The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Chronic progressive myelopathy associated with elevated antibodies to human T‐lymphotropic virus type I and adult T‐cell leukemialike cells
Abstract
Six adult patients had a chronic progressive myelopathy that possessed the following features: (1) high antibody titers to human T‐lymphotropic virus type I (HTLV‐I) in serum and cerebrospinal fluid (CSF); (2) predominantly upper motor neuron disorder, symmetrical, with mild sensory and bladder disturbances; and (3) presence of adult T‐cell leukemia–like cells in both peripheral blood and CSF. We refer to this entity as HTLV‐I–associated myelopathy (HAM). Electrophoretic studies of immunoglobulin G in CSF using Western blot analysis characteristically demonstrated p24 and p32 bands. Rates of intra‐blood–brain barrier synthesis were determined and found increased in the patients with HAM. Corticosteroid treatment produced clinical improvement in all of 4 patients. A retrospective survey of CSF samples was carried out in 287 patients with neurological disorders, and 6 additional patients with HAM were identified.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Experimental models of virus-induced demyelination of the central nervous system
Dal Canto, M. C., & Rabinowitz, S. G. (1982) · Annals of Neurology · doi:10.1002/ana.410110202 · Cited by 173
Cited by
Nagai, M., Usuku, K., Matsumoto, W., Kodama, D., Takenouchi, N., Moritoyo, T., Hashiguchi, S., Ichinose, M., Bangham, C. R., Izumo, S., et al. (1998) · Journal of Neurovirology · doi:10.3109/13550289809114225 · Cited by 694
Self-citationImmunological aspects of experimental allergic encephalomyelitis and multiple sclerosis
Martin, R., McFarland, H. F., & Boggs, J. M. (1995) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369509084683 · Cited by 376
Increased replication of HTLV‐I in HTLV‐I–associated myelopathy
Yoshida, M., Osame, M., Kawai, H., Toita, M., Kuwasaki, N., Nishida, Y., Hiraki, Y., Takahashi, K., Nomura, K., Sonoda, S., et al. (1989) · Annals of Neurology · doi:10.1002/ana.410260304 · Cited by 176
Self-citationKira, J., Koyanagi, Y., Yamada, T., Itoyama, Y., Goto, I., Yamamoto, N., Sasaki, H., & Sakaki, Y. (1991) · Annals of Neurology · doi:10.1002/ana.410290214 · Cited by 152
Kira, J.-I., Fujihara, K., Itoyama, Y., Goto, I., & Hasuo, K. (1991) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(91)90192-a · Cited by 96
Metadata
- Authors
- Osame, M., Matsumoto, M., Usuku, K., Izumo, S., Ijichi, N., Amitani, H., Tara, M., & Igata, A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1987-02
- Volume
- 21
- Issue
- 2
- Pages
- 117-122
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1978771608
- Cited by
- 625
- References
- 2
- FWCI
- 23.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Chronic progressive myelopathy associated with elevated antibodies to human T‐lymphotropic virus type I and adult T‐cell leukemialike cells. https://app.cochat.ai/papers/10.1002/ana.410210203
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- Osame, M., Matsumoto, M., Usuku, K., Izumo, S., Ijichi, N., Amitani, H., Tara, M., & Igata, A. (1987). Chronic progressive myelopathy associated with elevated antibodies to human T‐lymphotropic virus type I and adult T‐cell leukemialike cells. Annals of Neurology. https://doi.org/10.1002/ana.410210203
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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