The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cholinergic‐dependent cognitive deficits in Parkinson's disease
Abstract
In a double‐blind cross‐over study, the effects of a subthreshold dose of scopolamine (0.25 mg) on memory were compared in 32 control subjects and 32 parkinsonian patients who were without any sign of intellectual and mnemic impairment. Although the scores of the controls in the memory test battery showed no deterioration after the administration of scopolamine, the same dose resulted in significantly reduced memory performance in parkinsonian patients in two tests which involved the recognition of meaningless drawings. The selective vulnerability of parkinsonian subjects without cognitive impairment to a subthreshold dose of scopolamine suggests the existence of an underlying alteration of central cholinergic transmission. The neuropsychological findings in our study agree with postmortem biochemical data, which showed decreased cortical choline acetyltransferase activity in all parkinsonian patients, suggesting the existence of neuronal compensation in parkinsonian patients who are without cognitive impairment.
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Citations
Cites
Parkinson disease, dementia, and alzheimer disease: Clinicopathological correlations
Boller, F., Mizutani, T., Roessmann, U., & Gambetti, P. (1980) · Annals of Neurology · doi:10.1002/ana.410070408 · Cited by 451
Cited by
Cognitive Impairment in Parkinson’s Disease: The Dual Syndrome Hypothesis
Kehagia, A. A., Barker, R. A., & Robbins, T. W. (2013) · Neurodegenerative Diseases · doi:10.1159/000341998 · Cited by 573
Bohnen, N. I., Kaufer, D. I., Hendrickson, R., Ivanco, L. S., Lopresti, B. J., Constantine, G. M., Mathis, C. A., Davis, J. G., Moore, R. Y., & DeKosky, S. T. (2006) · Journal of Neurology · doi:10.1007/s00415-005-0971-0 · Cited by 364
Dopamine-dependent frontostriatal planning deficits in early Parkinson's disease.
Owen, A. M., Sahakian, B. J., Hodges, J. R., Summers, B. A., Polkey, C. E., & Robbins, T. W. (1995) · Neuropsychology · doi:10.1037//0894-4105.9.1.126 · Cited by 294
Williams-Gray, C. H., Foltynie, T., Lewis, S. J. G., & Barker, R. A. (2006) · CNS Drugs · doi:10.2165/00023210-200620060-00004 · Cited by 147
Metadata
- Authors
- Dubois, B., Danzé, F., Pillon, B., Cusimano, G., Lhermitte, F., & Agid, Y.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1987-07
- Volume
- 22
- Issue
- 1
- Pages
- 26-30
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2053098177
- Cited by
- 178
- References
- 1
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dubois, B., Danzé, F., Pillon, B., Cusimano, G., Lhermitte, F., & Agid, Y. (1987). Cholinergic‐dependent cognitive deficits in Parkinson's disease. Annals of Neurology. https://doi.org/10.1002/ana.410220108
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
