Cognitive Deficits and Psychosis in Parkinson???s Disease
Abstract
Parkinson's disease is a neurodegenerative disorder causing not only motor dysfunction but also cognitive, psychiatric, autonomic and sensory disturbances. Symptoms of dementia and psychosis are common: longitudinal studies suggest that up to 75% of patients with Parkinson's disease may eventually develop dementia, and the prevalence of hallucinations ranges from 16-17% in population-based surveys to 30-40% in hospital-based series. These cognitive and behavioural features are important in terms of prognosis, nursing home placement and mortality. The pattern of cognitive deficits in Parkinson's disease is variable, but often includes executive impairment similar to that seen in patients with frontal lesions, as well as episodic memory impairment, visuospatial dysfunction and impaired verbal fluency. The most common manifestation of psychosis in Parkinson's disease is visual hallucinations, but delusions, paranoid beliefs, agitation and florid psychosis can also occur. An understanding of the pathophysiology underlying these symptoms is essential to the development of targeted therapeutic strategies. Post-mortem studies suggest an association between Lewy body deposition and dementia in Parkinson's disease, and indeed Parkinson's disease and dementia with Lewy bodies may form part of the same disease spectrum. Whether Lewy bodies actually play a causative role in cognitive dysfunction, however, is unknown. Deficits in neurotransmitter systems provide more obvious therapeutic t…
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With advancing disease, Parkinson's disease patients may develop paranoid illusions often with persecutory ideas or suspicions towards the spouse.
“With advancing disease patients may develop paranoid illusions often with persecutory ideas or suspicions towards the spouse (Williams-Gray et al. 2006).”
From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Williams-Gray et al. 2006
Neuropathological changes in the amygdala and hippocampus caused by the disease process seem to be implicated in the aetiology of visual hallucinations in Parkinson's disease.
“Neuropathological changes in the amygdala and hippocampus caused by the disease process seem to be implicated in the aetiology (Williams-Gray et al. 2006).”
From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Williams-Gray et al. 2006
The earliest symptoms of cognitive deterioration in Parkinson's disease include problems with executive function, but visuospatial dysfunction, impaired speech fluency and memory impairment are also observed.
“The earliest symptoms include problems with executive function, i.e., planning and organizing goal-directed behaviour, but visuospatial dysfunction, impaired speech fluency and memory impairment are also observed (Williams-Gray et al. 2006).”
From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Williams-Gray et al. 2006
Cites
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
Gibb, W. R., & Lees, A. J. (1988) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.6.745 · Cited by 3,481 · see citing works
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The clinical symptoms of Parkinson's disease.
Sveinbjornsdottir, S. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13691 · Cited by 1,410 · see citing works
Tuscher, J. J., Taxier, L. R., Fortress, A. M., & Frick, K. M. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.11.002 · Cited by 88 · see citing works
- Authors
- Williams-Gray, C. H., Foltynie, T., Lewis, S. J. G., & Barker, R. A.
- Affiliations
- University of Cambridge (GB)
- Venue
- CNS Drugs
- Published
- 2006
- Volume
- 20
- Issue
- 6
- Pages
- 477-505
- ISSN
- 1172-7047 (ISSN-L)
- OpenAlex
- W1985004455
- Cited by
- 147
- References
- 1
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 1 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 12 · 2015: 11 · 2014: 8 · 2013: 12 · 2012: 4
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Drugs (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Parkinson's UK (G-4054)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- Parkinson's disease, psychosis, dementia, cognitive impairment, visual hallucinations, delusions, executive dysfunction, episodic memory impairment, Lewy bodies, dopaminergic dysfunction, cholinergic deficit, cholinesterase inhibitors, atypical antipsychotics, deep brain stimulation, modafinil, behavioural symptoms
- MeSH terms
- Cognition Disorders, Humans, Parkinson Disease, Psychotic Disorders
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