Cognitive correlates of cortical cholinergic denervation in Parkinson’s disease and parkinsonian dementia
Abstract
We recently reported findings that loss of cortical acetylcholinesterase (AChE) activity is greater in parkinsonian dementia than in Alzheimer's disease (AD). In this study we determined cognitive correlates of in vivo cortical AChE activity in patients with parkinsonian dementia (PDem, n = 11), Parkinson's disease without dementia (PD, n = 13), and in normal controls (NC, n = 14) using N-[(11)C]methyl-piperidin-4-yl propionate ([(11)C]PMP) AChE positron emission tomography (PET). Cortical AChE activity was significantly reduced in the PDem (-20.9%) and PD (-12.7 %) subjects (P < 0.001) when compared with the control subjects. Analysis of the cognitive data within the patient groups demonstrated that scores on the WAIS-III Digit Span, a test of working memory and attention, had most robust correlation with cortical AChE activity (R = 0.61, p < 0.005). There were also significant correlations between cortical AChE activity and other tests of attentional and executive functions, such as the Trail Making and Stroop Color Word tests. There was no significant correlation between cortical AChE activity and duration of motor disease (R = -0.01, ns) or severity of parkinsonian motor symptoms (R = 0.14, ns). We conclude that cortical cholinergic denervation in PD and parkinsonian dementia is associated with decreased performance on tests of attentional and executive functioning.
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The complex interaction between cholinergic and other transmitter systems participates in the pathophysiological mechanism of brain electricity slowing and cognitive decline in neurodegenerative diseases.
“Studies have shown that the complex interaction between cholinergic and other transmitter systems participates in the pathophysiological mechanism of brain electricity slowing and cognitive decline in neurodegenerative diseases [42-46].”
From QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis (2023) · cites this paper as [43]
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- Authors
- Bohnen, N. I., Kaufer, D. I., Hendrickson, R., Ivanco, L. S., Lopresti, B. J., Constantine, G. M., Mathis, C. A., Davis, J. G., Moore, R. Y., & DeKosky, S. T.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Bohnen, N. I.
- Venue
- Journal of Neurology
- Published
- 2005-09-02
- Volume
- 253
- Issue
- 2
- Pages
- 242-247
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W1986283880
- Cited by
- 364
- References
- 45
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 17 · 2023: 14 · 2022: 18 · 2021: 15 · 2020: 15 · 2019: 13 · 2018: 18 · 2017: 19 · 2016: 21 · 2015: 16 · 2014: 15 · 2013: 31 · 2012: 29
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pittsburgh
- VA Pittsburgh Healthcare System
- National Institute on Aging (AG 05-133, P50AG005133)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Parkinson's disease dementia, Parkinson's disease, acetylcholinesterase activity, cognitive correlates, attention, executive function, working memory, digit span, Trail Making Test, Stroop task, Alzheimer's disease comparison
- MeSH terms
- Acetylcholinesterase, Carbon Radioisotopes, Cerebral Cortex, Cognition, Dementia, Denervation, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Memory, Short-Term, Neuropsychological Tests, Parkinson Disease, Propionates, Positron-Emission Tomography
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