The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
The concept of coupling blood flow to brain function: Revision required?
Abstract
A tight coupling exists between brain function and cerebral perfusion in most situations. The Roy and Sherrington hypothesis has been widely accepted to account for the phenomenon: Increased neuronal metabolic activity will give rise to the accumulation of vasoactive catabolites, which decrease vascular resistance and thereby increase blood flow until normal homeostasis is reestablished. However, the hypothesis does not account for the disproportionate increase in flow that occurs in a number of circumstances. There are additional difficulties in reconciling more recent experimental data with the Roy and Sherrington hypothesis. In this review we direct attention toward the rich perivascular nerve supply to all parts of the cerebral circulation as possibly being an alternative control system allowing for rapid parallel changes in flow and neuronal activity.
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Citations
Cites
Cerebral Blood Flow and Oxygen Consumption in Man
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On the Regulation of the Blood‐supply of the Brain
Roy, C. S., & Sherrington, C. S. (1890) · The Journal of Physiology · doi:10.1113/jphysiol.1890.sp000321 · Cited by 1,822
Lassen, N. A. (1966) · The Lancet · doi:10.1016/s0140-6736(66)92199-4 · Cited by 912
Correlation Between Regional Cerebral Blood Flow and Oxidative Metabolism: In Vivo Studies in Man
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Local chemical and neurogenic regulation of cerebral vascular resistance.
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Kleinfeld, D., Mitra, P. P., Helmchen, F., & Denk, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15741 · Cited by 832
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Role of Astrocytes in Neurovascular Coupling
Petzold, G. C., & Murthy, V. N. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.009 · Cited by 409
Decreases in regional cerebral blood flow with normal aging
Martin, A. J., Friston, K. J., Colebatch, J. G., & Frackowiak, R. S. J. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.121 · Cited by 393
Metadata
- Authors
- Lou, H. C., Edvinsson, L., & MacKenzie, E. T.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1987-09
- Volume
- 22
- Issue
- 3
- Pages
- 289-297
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1994971749
- Cited by
- 301
- References
- 41
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
