The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Alz‐50 Antibody recognizes alzheimer‐related neuronal changes
Abstract
Alz‐50 is a monoclonal antibody directed against an antigen present in Alzheimer's disease. Unlike conventional pathological stains that reveal only neurons with neurofibrillary tangles (NFTs), Alz‐50 recognizes neurons that contain NFTs and additional neurons that do not. Our investigation of the topographical distribution of both NFT‐containing and non‐NFT‐containing neurons recognized by Alz‐50 reveals that they are both found primarily in certain cytoarchitectural areas and lamina that have been established as consistent sites for NFT pathology. Some of the neurons recognized by Alz‐50 appear histopathologically normal. We suggest that Alz‐50 recognizes an antigen in neurons that both precedes and accompanies NFT formation. Thus, it may mark a point early in cellular pathology before irreversible cytoskeletal and degenerative changes occur.
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Cites
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565
Self-citationAlzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Self-citationDavies, P., Katzman, R., & Terry, R. D. (1980) · Nature · doi:10.1038/288279a0 · Cited by 882
Self-citationPerforant pathway changes and the memory impairment of Alzheimer's disease
Hyman, B. T., Van Hoesen, G. W., Kromer, L. J., & Damasio, A. R. (1986) · Annals of Neurology · doi:10.1002/ana.410200406 · Cited by 672
Self-citationLewis, D., Campbell, M., Terry, R., & Morrison, J. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-06-01799.1987 · Cited by 578
Braak, H., Braak, E., Grundke-Iqbal, I., & Iqbal, K. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90288-0 · Cited by 432
Alzheimer's Neurofibrillary Changes: A Topographic Study
HIRANO, A. (1962) · Archives of Neurology · doi:10.1001/archneur.1962.04210030065009 · Cited by 402
Braak, H., & Braak, E. (1985) · Acta Neuropathologica · doi:10.1007/bf00690836 · Cited by 287
Cited by
Blennow, K., Wallin, A., Ågren, H., Spenger, C., Siegfried, J., & Vanmechelen, E. (1995) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815140 · Cited by 789
Braak, F., Braak, H., & Mandelkow, E. M. (1994) · Acta Neuropathologica · doi:10.1007/bf00293315 · Cited by 772
An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.
Kowall, N. W., Beal, M. F., Busciglio, J., Duffy, L. K., & Yankner, B. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7247 · Cited by 522
Cholinergic nucleus basalis tauopathy emerges early in the aging‐MCI‐AD continuum
Mesulam, M., Shaw, P., Mash, D., & Weintraub, S. (2004) · Annals of Neurology · doi:10.1002/ana.20100 · Cited by 374
Conformational change as one of the earliest alterations of tau in Alzheimer's disease
Weaver, C. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00157-3 · Cited by 310
Metadata
- Authors
- Hyman, B. T., Van Hoesen, G. W., Wolozin, B. L., Davies, P., Kromer, L. J., & Damasio, A. R.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1988-04
- Volume
- 23
- Issue
- 4
- Pages
- 371-379
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2004763497
- Cited by
- 176
- References
- 8
- FWCI
- 16.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hyman, B. T., Van Hoesen, G. W., Wolozin, B. L., Davies, P., Kromer, L. J., & Damasio, A. R. (1988). Alz‐50 Antibody recognizes alzheimer‐related neuronal changes. Annals of Neurology. https://doi.org/10.1002/ana.410230410
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
