Alzheimer's Neurofibrillary Changes: A Topographic Study
Abstract
Introduction The significance of Alzheimer's neurofibrillary changes has been actively discussed by neuropathologists over the past half a century, and numerous reports have been written concerning it. Their clinicoanatomical correlation with mental disease, their relation to senile plaques and other changes associated with aging, their cytological demonstration with silver impregnation techniques, as well as experimental attempts at their reproduction, have engaged many investigators. Topographic aspects of this neuronal alteration have been analyzed in certain parts of the central nervous system in a few conditions—the cerebral cortex in Alzheimer's disease and the senile psychoses, and the substantia nigra and brain stem in parkinsonism. Recent observations of neurofibrillary changes in 2 fatal neurologic diseases occurring on the island of Guam, the parkinsonism-dementia complex (Hirano, Kurland, Krooth, and Lessell1; Hirano, Malamud and Kurland2) and the amyotrophic lateral sclerosis syndrome (Malamud, Hirano and Kurland3), revealed their quite remarkable numbers and symmetric
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Previous studies helped establish the connection between amyloid-beta plaques, neurofibrillary tangles, and antemortem cognitive impairment.
“and previous studies that had also helped to establish the connection between AβPs, NFTs, and antemortem cognitive impairment (311-320).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [318]
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- Authors
- HIRANO, A.
- Corresponding author
- HIRANO, ASAO
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1962-09-01
- Volume
- 7
- Issue
- 3
- Pages
- 227
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2028666162
- Cited by
- 402
- References
- 31
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, neurofibrillary tangles, amyloid plaques, parkinsonism-dementia complex, amyotrophic lateral sclerosis, Guam, silver impregnation, neuropathology, cerebral cortex, substantia nigra, brainstem, aging
- MeSH terms
- Amyotrophic Lateral Sclerosis, Brain, Brain Diseases, Dementia, Hepatolenticular Degeneration, Humans, Parkinson Disease, Psychotic Disorders, Neurofibrillary Tangles
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