Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques
Abstract
Paired helical filaments, pathologically changed components of the cytoskeleton of human nerve cells, are demonstrated by a specific silver staining technique, immunostaining and electron microscopy. Accumulations of these filaments are found in the telencephalic cortex of old-aged individuals and patients suffering from Alzheimer's disease. Apart from neurofibrillary tangles and neuritic plaques, paired helical filaments are encountered in neuropil threads. At this third location, pathological filaments occur in small and inconspicuous profiles scattered throughout both allocortical and isocortical areas. The pattern of distribution and packing density of neuropil threads varies between different cortical areas and layers.
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Neuropil threads may represent the majority of tau burden in Alzheimer's disease, and they are thought to originate from neurons containing neurofibrillary tangles.
“Neuropil threads may represent the majority of tau burden in AD, and they are thought to originate from neurons containing NFTs [62–64].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [62]
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- Authors
- Braak, H., Braak, E., Grundke-Iqbal, I., & Iqbal, K.
- Corresponding author
- Braak, Heiko
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1986-04
- Volume
- 65
- Issue
- 3
- Pages
- 351-355
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1984827962
- Cited by
- 432
- References
- 14
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 14 · 2020: 10 · 2019: 12 · 2018: 7 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 5
- FWCI
- 12.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-05892, AG/NS-04220)
- National Institute of Neurological Disorders and Stroke (NS 18105)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuropil threads, paired helical filaments, Alzheimer's disease, neurofibrillary tangles, neuritic plaques, cytoskeletal filaments, silver staining, immunostaining, electron microscopy, cortical layers
- MeSH terms
- Aged, Aging, Alzheimer Disease, Brain, Cytoskeleton, Humans, Immune Sera, Intermediate Filaments, Microscopy, Electron, Middle Aged, Neurofibrils, Silver, Staining and Labeling
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