The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Restless legs syndrome: Clinicoetiologic correlates
Abstract
Despite recent attempts to better characterize restless legs syndrome (RLS), this neurologic disorder remains poorly understood. The relationship between idiopathic and secondary and between familial and sporadic (nonfamilial) cases have not been previously defined. We studied 54 patients (29 women and 25 men) who satisfied the diagnostic criteria for RLS. The mean age of the patients was 62.69 +/- 13.82 years, and the mean age at onset was 34.13 +/- 20.30 years. We found that 92% of patients with idiopathic RLS (without neuropathy) had a family history of RLS, whereas only 13% of those with neuropathic RLS (associated with peripheral neuropathy) had a positive family history. The sporadic/neuropathic patients were older at symptom onset and tended to have a more rapid progression than the familial/idiopathic patients. There were no other significant differences between the subgroups. Levodopa and dopamine agonists were the most effective treatments. We conclude that there are two major etiologic subgroups of RLS but that the two share central pathophysiologic mechanisms.
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Cites
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Cited by
Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology
Allen, R. P., Picchietti, D., Hening, W. A., Trenkwalder, C., Walters, A. S., & Montplaisi, J. (2003) · Sleep Medicine · doi:10.1016/s1389-9457(03)00010-8 · Cited by 2,900
Periodic limb movements in sleep: State-dependent excitability of the spinal flexor reflex
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Periodic limb movements in sleep: State-dependent excitability of the spinal flexor reflex
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Weinstock, L. B., Fern, S. E., & Duntley, S. P. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0021-0 · Cited by 56
Restless Legs Symptoms in Thyroid Disorders
Tan, E. K., Ho, S. C., Eng, P., Loh, L. M., Koh, L., Lum, S. Y., Teoh, M. L., Yih, Y., & Khoo, D. (2004) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2003.11.003 · Cited by 53
Metadata
- Authors
- Ondo, W., & Jankovic, J.
- Venue
- Neurology
- Published
- 1996-12
- Volume
- 47
- Issue
- 6
- Pages
- 1435-1441
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2020928843
- Cited by
- 317
- References
- 26
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
