The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Neocortical damage during HIV infection
Abstract
Clinical and pathologicals evidence of subcortical central nervous system (CNS) damage is observed commonly in patients with human immunodeficiency virus (HIV) encephalitis. Whether other CNS regions are also affected has not been well studied. We report neocortical damage in patients with HIV encephalitis. Using quantitative techniques, we demonstrate statistically significant thinning of the neocortex, with a loss of large cortical neurons. Qualitative and quantitative assessments of neocortical neuropil reveal a loss of synaptic density and vacuolation of dendritic processes. Failure to demonstrate an association of these changes with the presence of HIV antigens suggests that neocortical damage may be an indirect effect of HIV infection of the CNS.
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Citations
Cites
Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy
Koenig, S., Gendelman, H. E., Orenstein, J. M., Dal Canto, M. C., Pezeshkpour, G. H., Yungbluth, M., Janotta, F., Aksamit, A., Martin, M. A., & Fauci, A. S. (1986) · Science · doi:10.1126/science.3016903 · Cited by 1,698
The AIDS dementia complex: I. Clinical features
Navia, B. A., Jordan, B. D., & Price, R. W. (1986) · Annals of Neurology · doi:10.1002/ana.410190602 · Cited by 1,660
The AIDS dementia complex: II. Neuropathology
Navia, B. A., Cho, E., Petito, C. K., & Price, R. W. (1986) · Annals of Neurology · doi:10.1002/ana.410190603 · Cited by 1,269
The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex
Price, R. W., Brew, B., Sidtis, J., Rosenblum, M., Scheck, A. C., & Cleary, P. (1988) · Science · doi:10.1126/science.3277272 · Cited by 1,245
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Self-citationLevy, R. M., Bredesen, D. E., & Rosenblum, M. L. (1985) · Journal of Neurosurgery · doi:10.3171/jns.1985.62.4.0475 · Cited by 1,129
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HTLV-III Infection in Brains of Children and Adults with AIDS Encephalopathy
Shaw, G. M., Harper, M. E., Hahn, B. H., Epstein, L. G., Gajdusek, D. C., Price, R. W., Navia, B. A., Petito, C. K., O'Hara, C. J., Groopman, J. E., et al. (1985) · Science · doi:10.1126/science.2981429 · Cited by 897
Some morphometric aspects of the brain in senile dementia of the alzheimer type
Terry, R. D., Peck, A., DeTeresa, R., Schechter, R., & Horoupian, D. S. (1981) · Annals of Neurology · doi:10.1002/ana.410100209 · Cited by 801
Self-citationHIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists
Dreyer, E. B., Kaiser, P. K., Offermann, J. T., & Lipton, S. A. (1990) · Science · doi:10.1126/science.2326646 · Cited by 591
Cited by
Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminals
Honer, W. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.04.005 · Cited by 135
Metadata
- Authors
- Wiley, C. A., Masliah, E., Morey, M., Lemere, C., DeTeresa, R., Grafe, M., Hansen, L., & Terry, R.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1991-06
- Volume
- 29
- Issue
- 6
- Pages
- 651-657
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2132586158
- Cited by
- 455
- References
- 21
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Neocortical damage during HIV infection. https://app.cochat.ai/papers/10.1002/ana.410290613
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- Wiley, C. A., Masliah, E., Morey, M., Lemere, C., DeTeresa, R., Grafe, M., Hansen, L., & Terry, R. (1991). Neocortical damage during HIV infection. Annals of Neurology. https://doi.org/10.1002/ana.410290613
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
