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HTLV-III Infection in Brains of Children and Adults with AIDS Encephalopathy
Abstract
Unexplained debilitating dementia or encephalopathy occurs frequently in adults and children with the acquired immune deficiency syndrome (AIDS). Brains from 15 individuals with AIDS and encephalopathy were examined by Southern analysis and in situ hybridization for the presence of human T-cell leukemia (lymphotropic) virus type III (HTLV-III), the virus believed to be the causative agent of AIDS. HTLV-III DNA was detected in the brains of five patients, and viral-specific RNA was detected in four of these. In view of these findings and the recent demonstration of morphologic and genetic relatedness between HTLV-III and visna virus, a lentivirus that causes a chronic degenerative neurologic disease in sheep, HTLV-III should be evaluated further as a possible cause of AIDS encephalopathy.
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Citations
Cited by
Heinzinger, N. K., Bukinsky, M. I., Haggerty, S. A., Ragland, A. M., Kewalramani, V, Lee, M. A., Gendelman, H. E., Ratner, L., Stevenson, M., & Emerman, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7311 · Cited by 854
Katzman, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198604103141506 · Cited by 801
Starcich, B. R., Hahn, B. H., Shaw, G. M., McNeely, P. D., Modrow, S., Wolf, H., Parks, E. S., Parks, W. P., Josephs, S. F., Gallo, R. C., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90778-6 · Cited by 767
Self-citationInduction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III
Letvin, N. L., Daniel, M. D., Sehgal, P. K., Desrosiers, R. C., Hunt, R. D., Waldron, L. M., MacKey, J. J., Schmidt, D. K., Chalifoux, L. V., & King, N. W. (1985) · Science · doi:10.1126/science.2412295 · Cited by 616
Petito, C. K., Navia, B. A., Cho, E.-S., Jordan, B. D., George, D. C., & Price, R. W. (1985) · New England Journal of Medicine · doi:10.1056/nejm198504043121402 · Cited by 561
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Metadata
- Authors
- Shaw, G. M., Harper, M. E., Hahn, B. H., Epstein, L. G., Gajdusek, D. C., Price, R. W., Navia, B. A., Petito, C. K., O'Hara, C. J., Groopman, J. E., Cho, E.-S., Oleske, J. M., Wong-Staal, F., & Gallo, R. C.
- Venue
- Science
- Published
- 1985-01-11
- Volume
- 227
- Issue
- 4683
- Pages
- 177-182
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974905296
- Cited by
- 897
- References
- 0
- FWCI
- 34.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: HTLV-III Infection in Brains of Children and Adults with AIDS Encephalopathy. https://app.cochat.ai/papers/10.1126/science.2981429
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- Shaw, G. M., Harper, M. E., Hahn, B. H., Epstein, L. G., Gajdusek, D. C., Price, R. W., Navia, B. A., Petito, C. K., O'Hara, C. J., Groopman, J. E., Cho, E.-S., Oleske, J. M., Wong-Staal, F., & Gallo, R. C. (1985). HTLV-III Infection in Brains of Children and Adults with AIDS Encephalopathy. Science. https://doi.org/10.1126/science.2981429
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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