The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.
An introduction to the free radical hypothesis in Parkinson's disease
Abstract
Iron-induced oxidant stress has been implicated in the pathogenesis of Parkinson's disease. An increasing body of evidence now indicates that in Parkinson's disease the environment within the substantia nigra is conducive to the formation of cytotoxic free radicals and cell degeneration. Dopamine neurons may be particularly vulnerable because of the oxidative metabolism of dopamine and the potential of neuromelanin to promote the site-specific accumulation and reduction of iron. This hypothesis has attracted considerable attention because it opens the way for employing antioxidant strategies as possible neuroprotective treatment for Parkinson's disease. Although the concept is appealing, free radicals have not yet been proven to play a role in Parkinson's disease, and many important issues remain to be resolved before the oxidative hypothesis can ultimately be confirmed or refuted.
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“This observation is in agreement with a similar analysis that was performed on autopsy specimens ([51](#R51)).”
From Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease (1997) · cites this paper as [51]
Citations
Cites
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Cited by
Sorted by citations
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
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Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
Jack, C. R., Petersen, R. C., Xu, Y. C., Waring, S. C., O'Brien, P. C., Tangalos, E. G., Smith, G. E., Ivnik, R. J., & Kokmen, E. (1997) · Neurology · doi:10.1212/wnl.49.3.786 · Cited by 1,128
Metadata
- Authors
- Olanow, C. W.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Olanow, C. W.
- ORCID
- Olanow, C. W.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1992
- Volume
- 32
- Issue
- S1
- Pages
- S2-S9
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2156259977
- Cited by
- 382
- References
- 68
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 13
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, oxidative stress, iron accumulation, substantia nigra, dopaminergic neurons, neuromelanin, dopamine oxidation, neuroprotection, antioxidants, neurodegeneration
- MeSH terms
- Animals, Free Radicals, Humans, Iron, Parkinson Disease, Substantia Nigra, Lipid Peroxidation
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