The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
The role of calcium‐binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis
Abstract
The factors contributing to selective motoneuron loss in amyotrophic lateral sclerosis (ALS) remain undefined. To investigate whether calcium‐binding proteins contribute to selective motoneuron vulnerability in ALS, we compared calbindin‐D 28K and parvalbumin immunoreactivity in motoneuron populations in human ALS, and in a ventral spinal cord hybrid cell line selectively vulnerable to the cytotoxic effects of ALS IgG. In human autopsy specimens, immunoreactive calbindin‐D 28K and parvalbumin were absent in motoneuron populations lost early in ALS (i.e., cortical and spinal motoneurons, lower cranial nerve motoneurons), while motoneurons damaged late or infrequently in the disease (i.e., Onuf's nucleus motoneurons, oculomotor, trochlear, and abducens nerve neurons) expressed markedly higher levels of immunoreactive calbindin‐D 28K and/or parvalbumin. Motoneuron–neuroblastoma VSC 4.1 hybrid cells lost immunoreactive calbindin‐D 28K and parvalbumin following dibutyryl‐cyclic AMP–induced differentiation and were killed by IgG from ALS patients. Undifferentiated calbindin/parvalbumin‐reactive VSC 4.1 cells were not killed, nor were other cell lines expressing high levels of calbindin‐D 28K and parvalbumin immunoreactivity (substantia nigra–neuroblastoma hybrid cells and N18TG2 neuroblastoma parent cells). These studies suggest that decreased calbindin‐D 28K and parvalbumin immunoreactivity may help explain the selective vulnerability of motoneurons in ALS.
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Amyotrophic Lateral Ssclerosis and Structural Defects in Cu,Zn Superoxide Dismutase
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UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS
Bruijn, L. I., Miller, T. M., & Cleveland, D. W. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144244 · Cited by 1,185
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
Cavalli, A., Bolognesi, M. L., Minarini, A., Rosini, M., Tumiatti, V., Recanatini, M., & Melchiorre, C. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm7009364 · Cited by 1,152
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
Pasinelli, P., & Brown, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1971 · Cited by 1,107
Ageing and neuronal vulnerability
Mattson, M. P., & Magnus, T. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1886 · Cited by 957
Mattson, M. P. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00275.x · Cited by 751
Metadata
- Authors
- Alexianu, M. E., Ho, B., Mohamed, A. H., La Bella, V., Smith, R. G., & Appel, S. H.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1994-12
- Volume
- 36
- Issue
- 6
- Pages
- 846-858
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2040754808
- Cited by
- 375
- References
- 41
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Alexianu, M. E., Ho, B., Mohamed, A. H., La Bella, V., Smith, R. G., & Appel, S. H. (1994). The role of calcium‐binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis. Annals of Neurology. https://doi.org/10.1002/ana.410360608
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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