The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate
Abstract
A potential mechanism of neuronal injury in neurodegenerative diseases is a defect in energy metabolism that may lead to slow excitotoxic neuronal death. Consistent with this possibility, we showed that specific inhibitors of the electron transport chain produce excitotoxic lesions in vivo. In the present study we examined whether agents that improve energy metabolism can block lesions produced by the mitochondrial toxin malonate. Striatal lesions produced by the complex II inhibitor malonate were blocked in a dose‐dependent manner by oral pretreatment with coenzyme Q 10. Administration of nicotinamide by Alzet pump for 1 week attenuated malonate‐induced lesions, but riboflavin had no effect. Administration of nicotinamide intraperitoneally just prior to and following induction of the lesions produced dose‐dependent neuroprotection. A combination of coenzyme Q 10 with nicotinamide was more effective than either compound alone, as shown by both lesion size and magnetic resonance imaging in vivo. Both coenzyme Q 10 and nicotinamide blocked adenosine triphosphate depletions and lactate increases. These results confirm that mitochondrial toxins produce striatal excitotoxic lesions by a mechanism involving energy depletion in vivo. Furthermore, they suggest novel neuroprotective strategies that may be useful in the treatment of both mitochondrial encephalopathies and neurodegenerative diseases.
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“Oral administration of CoQ10 exerts significant neuroprotective effects against striatal lesions in rats produced by aminoxyacetic acid, and the mitochondrial toxins malonate and 3-NP148-150.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [148]
In the citing paper
“Oral administration of CoQ10 produced dose-dependent neuroprotective effects against malonate induced striatal lesions, depletion of ATP and increases in lactate concentration148.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [148]
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Cites
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
Fluorometric assay of proteins in the nanogram range
Böhlen, P., Stein, S., Dairman, W. M., & Udenfriend, S. (1973) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(73)80023-2 · Cited by 1,632
Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity
Zhang, J., Dawson, V. L., Dawson, T. M., & Snyder, S. H. (1994) · Science · doi:10.1126/science.8080500 · Cited by 1,118
Beal, M. F., Brouillet, E., Jenkins, B. G., Ferrante, R. J., Kowall, N. W., Miller, J., Storey, E., Srivastava, R., Rosen, B. R., & Hyman, B. T. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04181.1993 · Cited by 1,026
Self-citationBeal, M. F. (1992) · Annals of Neurology · doi:10.1002/ana.410310202 · Cited by 962
Self-citationNovelli, A., Reilly, J. A., Lysko, P. G., & Henneberry, R. C. (1988) · Brain Research · doi:10.1016/0006-8993(88)90765-2 · Cited by 961
Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.
Frei, B. B., Kim, M. C., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4879 · Cited by 623
Alternative excitotoxic hypotheses
Albin, R. L., & Greenamyre, J. T. (1992) · Neurology · doi:10.1212/wnl.42.4.733 · Cited by 574
Frahm, J., Bruhn, H., Gyngell, M. L., Merboldt, K. D., Hänicke, W., & Sauter, R. (1989) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910110105 · Cited by 522
Shoffner, J. M., Lott, M. T., Voljavec, A. S., Soueidan, S. A., Costigan, D. A., & Wallace, D. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.7952 · Cited by 507
Research works printed but not linked: 6
- Beal K, 1993, Both local and systemic administration of the mitochondrial toxin sodium azide result in striatal lesions by an excitotoxic mechanism, Neurology, 43, A407
- Nakamura K, 1989, Biochemical and clinical aspects of coenzyme Q10, 3
- OkamotoK KobayashiK TakahashiK et al.Biochemical roles of coenzyme Q on cultured ventricular myocytes: effects of coenzyme Q on mitochondrial ATP productionPresented at the 8th international coenzyme Q symposium Stockholm Sweden Nov 11 1993
- Barbiroli K, 1994, Improved brain and muscle energy metabolism in patients with mitochondrial cytopathies treated with coenzyme, Q. Neurology, 44, A404
- Heb K, 1993, Proceedings of Society of Magnetic Resonance Medicine 12th annual meeting, 1557
- Koroshetz K, 1993, Ubiquinone lowers occipital lactate levels in patients with Huntington's disease, Neurology, 43, A334
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Metadata
- Authors
- Beal, M. F., Henshaw, D. R., Jenkins, B. G., Rosen, B. R., & Schulz, J. B.
- Affiliations
- Massachusetts General Hospital (US)
- Harvard University (US)
- Corresponding author
- Beal, M. Flint
- ORCID
- Rosen, Bruce R.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1994-12
- Volume
- 36
- Issue
- 6
- Pages
- 882-888
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1965876571
- Cited by
- 189
- References
- 35
- Citations by year
- 2026: 1 · 2024: 5 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 6
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ns031579-05)
- U.S. Public Health Service (16367)
- National Institute of Neurological Disorders and Stroke (NS10828, NS31579)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- coenzyme Q10, nicotinamide, malonate, mitochondrial toxins, striatal lesions, excitotoxicity, neuroprotection, mitochondrial bioenergetics, electron transport inhibition, complex II inhibition, ATP depletion, lactate, mitochondrial encephalopathy, neurodegenerative diseases
- MeSH terms
- Animals, Coenzymes, Corpus Striatum, Dose-Response Relationship, Drug, Magnetic Resonance Imaging, Male, Malonates, Mitochondria, Niacinamide, Ubiquinone, Rats, Sprague-Dawley, Rats
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