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Cited by 189Coenzyme Q10 studies and effectsMitochondrial Function and PathologyNeuroprotection in Cerebral Ischemia

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate

Beal, M. Flint, Henshaw, D. Ross, Jenkins, Bruce G., Rosen, Bruce R., Schulz, Jourg B.·1994·Annals of Neurology
DOI 10.1002/ana.410360613
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Abstract

A potential mechanism of neuronal injury in neurodegenerative diseases is a defect in energy metabolism that may lead to slow excitotoxic neuronal death. Consistent with this possibility, we showed that specific inhibitors of the electron transport chain produce excitotoxic lesions in vivo. In the present study we examined whether agents that improve energy metabolism can block lesions produced by the mitochondrial toxin malonate. Striatal lesions produced by the complex II inhibitor malonate were blocked in a dose‐dependent manner by oral pretreatment with coenzyme Q 10. Administration of nicotinamide by Alzet pump for 1 week attenuated malonate‐induced lesions, but riboflavin had no effect. Administration of nicotinamide intraperitoneally just prior to and following induction of the lesions produced dose‐dependent neuroprotection. A combination of coenzyme Q 10 with nicotinamide was more effective than either compound alone, as shown by both lesion size and magnetic resonance imaging in vivo. Both coenzyme Q 10 and nicotinamide blocked adenosine triphosphate depletions and lactate increases. These results confirm that mitochondrial toxins produce striatal excitotoxic lesions by a mechanism involving energy depletion in vivo. Furthermore, they suggest novel neuroprotective strategies that may be useful in the treatment of both mitochondrial encephalopathies and neurodegenerative diseases.

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Crossref · 10.1002/ana.410360613

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Show all 35 references

Research works printed but not linked: 6

  1. Beal K, 1993, Both local and systemic administration of the mitochondrial toxin sodium azide result in striatal lesions by an excitotoxic mechanism, Neurology, 43, A407
  2. Nakamura K, 1989, Biochemical and clinical aspects of coenzyme Q10, 3
  3. OkamotoK KobayashiK TakahashiK et al.Biochemical roles of coenzyme Q on cultured ventricular myocytes: effects of coenzyme Q on mitochondrial ATP productionPresented at the 8th international coenzyme Q symposium Stockholm Sweden Nov 11 1993
  4. Barbiroli K, 1994, Improved brain and muscle energy metabolism in patients with mitochondrial cytopathies treated with coenzyme, Q. Neurology, 44, A404
  5. Heb K, 1993, Proceedings of Society of Magnetic Resonance Medicine 12th annual meeting, 1557
  6. Koroshetz K, 1993, Ubiquinone lowers occipital lactate levels in patients with Huntington's disease, Neurology, 43, A334

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Metadata

Authors
Beal, M. F., Henshaw, D. R., Jenkins, B. G., Rosen, B. R., & Schulz, J. B.
Affiliations
  • Massachusetts General Hospital (US)
  • Harvard University (US)
Corresponding author
Beal, M. Flint
ORCID
Rosen, Bruce R.
Venue
Annals of Neurology
Publisher
Wiley
Published
1994-12
Volume
36
Issue
6
Pages
882-888
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.410360613
OpenAlex
W1965876571
Cited by
189
References
35
Citations by year
2026: 1 · 2024: 5 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 6
FWCI
2.78
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3599 d)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01ns031579-05)
  • U.S. Public Health Service (16367)
  • National Institute of Neurological Disorders and Stroke (NS10828, NS31579)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords
coenzyme Q10, nicotinamide, malonate, mitochondrial toxins, striatal lesions, excitotoxicity, neuroprotection, mitochondrial bioenergetics, electron transport inhibition, complex II inhibition, ATP depletion, lactate, mitochondrial encephalopathy, neurodegenerative diseases
MeSH terms
Animals, Coenzymes, Corpus Striatum, Dose-Response Relationship, Drug, Magnetic Resonance Imaging, Male, Malonates, Mitochondria, Niacinamide, Ubiquinone, Rats, Sprague-Dawley, Rats

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