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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

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Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

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An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants

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Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

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Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

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A Familial Alzheimer's Disease Locus on Chromosome 1

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Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene

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Suppression of Amyloid Deposition Leads to Long-Term Reductions in Alzheimer's Pathologies in Tg2576 Mice

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Secretases as therapeutic targets for the treatment of Alzheimer's disease

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p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing

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Alzheimer's disease due to an intronic presenilin-1 (PSEN1 intron 4) mutation

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Genetic and biochemical markers for Alzheimer's disease: recent developments

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Implication of Rho GTPases in Neurodegenerative Diseases

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Animal Models of Neurological Disease

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Plasma β-amyloid as potential biomarker of Alzheimer disease: possibility of diagnostic tool for Alzheimer disease

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Novel presenilin-1 mutation with widespread cortical amyloid deposition but limited cerebral amyloid angiopathy

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Amyloid β protein (Aβ) deposition in dementia with Lewy bodies: predominance of Aβ42(43) and paucity of Aβ40 compared with sporadic Alzheimer’s disease

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Oral Glucose Loading Modulates Plasma β-Amyloid Level in Alzheimer’s Disease Patients: Potential Diagnostic Method for Alzheimer’s Disease

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Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein

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Biomarkers for the Clinical Diagnosis of Alzheimer’s Disease: Metabolomics Analysis of Brain Tissue and Blood

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Localization and Possible Functions of Presenilins in Brain

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Hypericin inhibits oligomeric amyloid β42-induced inflammation response in microglia and ameliorates cognitive deficits in an amyloid β injection mouse model of Alzheimer's disease by suppressing MKL1

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A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations

Dowjat, W. K., Kuchna, I., Wısnıewskı, T., & Węgiel, J. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6105 · Cited by 27

Amyloid-Beta Peptide, Oxidative Stress and Inflammation in Alzheimer's Disease: Potential Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids

Dyall, S. C. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/274128 · Cited by 28

Immunoreactivity of Presenilin-1 and Tau in Alzheimer's Disease Brain

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Amyloid-β-protein isoforms in brain of subjects with PS1-linked, βAPP-linked and sporadic Alzheimer disease

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Presenilin mutations associated with fronto‐temporal dementia

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Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition

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Presenilins, β-amyloid precursor protein and the molecular basis of Alzheimer's disease

Selkoe, D. J. (2001) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(00)00016-5 · Cited by 24

Generation of a recombinant Fab antibody reactive with the Alzheimer's disease-related Aβ peptide

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Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease

Day, G. S., Musiek, E. S., Roe, C. M., Norton, J. B., Goate, A., Cruchaga, C., Cairns, N. J., & Morris, J. C. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.1236 · Cited by 21

The novel cytosolic RING finger protein dactylidin is up‐regulated in brains of patients with Alzheimer's disease

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Tau phosphorylation in cells transfected with wild-type or an Alzheimer's disease mutant Presenilin 1

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Refining the amyloid β peptide and oligomer fingerprint ambiguities in Alzheimer’s disease: Mass spectrometric molecular characterization in brain, cerebrospinal fluid, blood, and plasma

Michno, W., Blennow, K., Zetterberg, H., & Brinkmalm, G. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15466 · Cited by 18

Substrate recruitment by γ-secretase

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Alzheimer's disease or Alzheimer's diseases? clues from molecular epidemiology

Hyman, B. T. (1996) · Annals of Neurology · doi:10.1002/ana.410400202 · Cited by 19

Fractal analysis of amyloid plaques in Alzheimer's disease patients and mouse models

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Differential effects of transforming growth factor-βs and glial cell line-derived neurotrophic factor on gene expression of presenilin-1 in human post-mitotic neurons and astrocytes

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Extracellular Sortilin Proteopathy Relative to β-Amyloid and Tau in Aged and Alzheimer’s Disease Human Brains

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A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain

Green, E., Thaker, U., McDonagh, A. M., Iwatsubo, T., Lambert, J., Chartier‐Harlin, M., Harris, J. M., Pickering-Brown, S. M., Lendon, C. L., & Mann, D. M. A. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00190-8 · Cited by 17

An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid β protein deposited in Alzheimer's disease

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Presenilin-1 Polymorphism in Alzheimer's Disease and Vascular Dementia

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Aβ42, Presenilins, and Alzheimer’s Disease

Iwatsubo, T. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00027-x · Cited by 14

Genetic Complexity of Early-Onset Alzheimer’s Disease

Ghani, M., Reitz, C., George‐Hyslop, P. S., & Rogaeva, E. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-72938-1_3 · Cited by 15

Using Turmeric Oil as a Solvent Improves the Distribution of Sesamin‐Sesamolin in the Serum and Brain of Mice

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CDK5 Targeting as a Therapy for Recovering Neurovascular Unit Integrity in Alzheimer’s Disease

Posada-Duque, R. A., & Cardona-Gómez, G. P. (2021) · Journal of Alzheimer's Disease · doi:10.3233/jad-200730 · Cited by 14

What Have We Learned from Cerebrospinal Fluid Studies about Biomarkers for Detecting LRRK2 Parkinson’s Disease Patients and Healthy Subjects with Parkinson’s-Associated LRRK2 Mutations?

Loeffler, D. A., Aasly, J. O., LeWitt, P. A., & Coffey, M. P. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-191630 · Cited by 13

AMY plaques in familial AD

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Clinical rationale of genetic testing in dementia.

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Presenilin‐I polymorphism and hereditary cerebral hemorrhage with amyloidosis, Dutch type

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Evaluation of structure–activity relationships of ginsenosides against amyloid β induced pathological behaviours in transgenic Caenorhabditis elegans

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Genetics of Alzheimer Disease

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Biomarker identification in neurologic diseases: improving diagnostics and therapeutics

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Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease

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Alzheimer’s Disease and Dementia

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Processing of Wild‐Type and Mutant Familial Alzheimer’s Disease‐Associated Presenilin‐1 in Cultured Neurons

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Autosomal Dominant Alzheimer’s Disease: Underlying Causes

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Genetics and pathology of alpha-secretase site AβPP mutations in the understanding of Alzheimer's disease

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Aß40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aß42 toxicity in Drosophila

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Carboxy‐terminal truncation of long‐tailed amyloid β‐peptide is inhibited by serine protease inhibitor and peptide aldehyde

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Potential therapeutic targets for Alzheimer’s disease

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Neuropathology

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How and Why to Apply the Latest Technology*

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Amyloid .BETA. Peptides and Presenilins in the Pathogenesis of Alzheimer's Disease.

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No Detected Mutations in the Genes for the Amyloid Precursor Protein and Presenilins 1 and 2 in a Swiss Early-Onset Alzheimer’s Disease Family with a Dominant Mode of Inheritance

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Presenilin Proteins and Their Function During Embryonic Development and Alzheimer’s Disease

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Evidence for presenilin-1 involvement in amyloid angiopathy in the Alzheimer's disease-affected brain

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Presenilin immunoreactivity in Alzheimer's disease

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Alzheimer’s Disease: Causes, Mechanisms, and Steps Toward Prevention

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Identification of Peptides Binding to Presenilin 1 by Screening of Random Peptide Display Libraries

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The Biological Significance of Neuropathological Lesions in Alzheimer’s Disease

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The Role of the Presenilins in Alzheimer's Disease

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Etiology, Genetics, and Pathogenesis of Alzheimer's Disease

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Alzheimer's Disease

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Clinical and Genetic Aspects of Hereditary Cerebral Hemorrhage with Amyloidosis Dutch Type (HCHW A-D)

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Genetics, Alzheimer’s disease and Down syndrome

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CHAPTER 5.6 Identification and functional analysis of genes and genetic risk factors in Alzheimer's disease

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The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: II Experimental Evidence and Clinical Studies

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The Association Between Traumatic Brain Injury and Alzheimer's Disease: Mouse Models and Potential Mechanisms

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Transgenic Mice Overexpressing Presenilin cDNAs

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Neuronal dysfunction in aging and Alzheimer´s disease

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Pathological Changes in the Elderly Human Brain

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The Principle Syndromes of Dementia

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Etiological Considerations

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The light at the end of the tunnel : study of early-stage brain dynamics alterations in Alzheimer’s disease and beneficial effects of light stimulation in the AppNL-F/MAPT mouse model

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Amyloid-β plaque diversity across brain regions in Alzheimer’s disease and its relation to major clinicopathological traits

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Alzheimer’s Disease: A Matter of Dominance

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A unifying hypothesis of alzheimer’s disease: III—Risk factors

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Amyloid beta protein (A beta) deposition in chromosome 14-linked Alzheimer's disease: Predominance of A beta(42(43))

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Amyloid (Aβ) deposition in chromosome 1–linked Alzheimer's disease: The volga german families

Mann, D. M. A., Iwatsubo, T., Nochlin, D., Sumi, S. M., Levy‐Lahad, E., & Bird, T. D. (1997) · Annals of Neurology · doi:10.1002/ana.410410110 · Cited by 51

The PSEN1 I143T mutation in a Swedish family with Alzheimer's disease: clinical report and quantification of Aβ in different brain regions

Keller, L., Welander, H., Chiang, H., Tjernberg, L. O., Nennesmo, I., Wallin, Å. K., & Graff, C. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.107 · Cited by 40

Amyloid Angiopathy and Variability in Amyloid β Deposition Is Determined by Mutation Position in Presenilin-1-Linked Alzheimer’s Disease

Mann, D. M. A., Pickering-Brown, S. M., Takeuchi, A., & Iwatsubo, T. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64688-3 · Cited by 182

Apolipoprotein E Genotype and Deposits of Aβ40 and Aβ42 in Alzheimer Disease

McNamara, M. J., Gómez‐Isla, T., & Hyman, B. T. (1998) · Archives of Neurology · doi:10.1001/archneur.55.7.1001 · Cited by 55