Amyloid β protein (Aβ) deposition in chromosome 14–linked Alzheimer's disease: Predominance of Aβ42(43)

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051

Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., et al. (1995) · Nature · doi:10.1038/376775a0 · Cited by 2,052

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

Jarrett, J. T., Berger, E. P., & Lansbury, P. T. (1993) · Biochemistry · doi:10.1021/bi00069a001 · Cited by 2,022

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., & Ihara, Y. (1994) · Neuron · doi:10.1016/0896-6273(94)90458-8 · Cited by 1,774

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants

Suzuki, N., Cheung, T. T., Cai, X.-D., Odaka, A., Otvos, L., Eckman, C., Golde, T. E., & Younkin, S. G. (1994) · Science · doi:10.1126/science.8191290 · Cited by 1,471

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

Levy, E., Carman, M. D., Fernandez-Madrid, I. J., Power, M. D., Lieberburg, I. M., van Duinen, S. G., Bots, G. T. A. M., Luyendijk, W., & Frangione, B. (1990) · Science · doi:10.1126/science.2111584 · Cited by 1,399

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

Schellenberg, G. D., Bird, T. D., Wijsman, E. M., Orr, H. T., Anderson, L., Nemens, E. J., White, J. A., Bonnycastle, L. L., Weber, J. L., Alonso, M. E., et al. (1992) · Science · doi:10.1126/science.1411576 · Cited by 957

A Familial Alzheimer's Disease Locus on Chromosome 1

Levy‐Lahad, E., Wijsman, E. M., Nemens, E. J., Anderson, L., Goddard, K. A. B., Weber, J. L., Bird, T. D., & Schellenberg, G. D. (1995) · Science · doi:10.1126/science.7638621 · Cited by 832

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene

Hendriks, L., van Duijn, C. M., Cras, P. P., Cruts, M., Hul, W. V., van Harskamp, F., Warren, A., McInnis, M. G., Antonarakis, S. E., Martin, J., et al. (1992) · Nature Genetics · doi:10.1038/ng0692-218 · Cited by 741

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

Clark, R. F., Hutton, M., Fuldner, M., Froelich, S., Karran, E., Talbot, C., Crook, R., Lendon, C., Prihar, G., He, C., et al. (1995) · Nature Genetics · doi:10.1038/ng1095-219 · Cited by 474

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

George‐Hyslop, P. S., Haines, J. L., Rogaev, E. I., Mortilla, M., Vaula, G., Pericak‐Vance, M. A., Foncin, J. P., Montesi, M. P., Bruni, A. C., Sorbi, S., et al. (1992) · Nature Genetics · doi:10.1038/ng1292-330 · Cited by 467

Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome

Iwatsubo, T., Mann, D. M. A., Odaka, A., Suzuki, N., & Ihara, Y. (1995) · Annals of Neurology · doi:10.1002/ana.410370305 · Cited by 386

Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3

Broeckhoven, C. V., Backhovens, H., Cruts, M., Winter, G. D., Bruyland, M., Cras, P. P., & Martin, J. (1992) · Nature Genetics · doi:10.1038/ng1292-335 · Cited by 328

Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease.

van Duinen, S. G., Castaño, E. M., Prelli, F., Bots, G. T. A. M., Luyendijk, W., & Frangione, B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5991 · Cited by 310

Mutations of the presenilin I gene in families with early-onset Alzheimer's disease

Campion, D., Flaman, J., Brice, A., Hannequin, D., Dubois, B., Martin, C., Moreau, V., Charbonnier, F., Didierjean, O., Tardieu, S., et al. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.12.2373 · Cited by 277

A locus for familial early–onset Alzhelmer's disease on the long arm of chromosome 14, proximal to the α1–antichymotrypsin gene

Mullan, M., Houlden, H., Windelspecht, M., Fidani, L., Lombardi, C., Diaz, P., Rossor, M. N., Crook, R., Hardy, J., Duff, K., et al. (1992) · Nature Genetics · doi:10.1038/ng1292-340 · Cited by 277

A mutation in Alzheimerʼs disease destroying a splice acceptor site in the presenilin-1 gene

Pérez‐Tur, J., Froelich, S., Prihar, G., Crook, R., Baker, M., Duff, K., Wragg, M. A., Busfield, F., Lendon, C. L., Clark, R. F., et al. (1995) · Neuroreport · doi:10.1097/00001756-199512000-00071 · Cited by 264

Apolipoprotein E Affects the Rate of Alzheimer Disease Expression: β-Amyloid Burden Is a Secondary Consequence Dependent on APOE Genotype and Duration of Disease

Roses, A. D. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00002 · Cited by 252

Presenilins and Alzheimer disease

Broeckhoven, C. V. (1995) · Nature Genetics · doi:10.1038/ng1195-230 · Cited by 187

Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.

Mann, D. M. A., Iwatsubo, T., Ihara, Y., Cairns, N. J., Lantos, P. L., Bogdanović, N., Lannfelt, L., Winblad, B. G., Maat–Schieman, M. L. C., & Rossor, M. N. (1996) · Europe PMC (PubMed Central) · Cited by 184

Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3

Cruts, M., Backhovens, H., Wang, S., Gassen, G. V., Theuns, J., Jonghe, C. D., Wehnert, A., Voecht, J. D., Winter, G. D., Cras, P. P., et al. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.12.2363 · Cited by 180

APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain

Tamaoka, A., Odaka, A., Ishibashi, Y., Usami, M., Sahara, N., Suzuki, N., Nukina, N., Mizusawa, H., Shoji, S., & Kanazawa, I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)30050-8 · Cited by 168

Phenotypic heterogeneity in familial alzheimer's disease: A study of 24 kindreds

Bird, T. D., Sumi, S. M., Nemens, E. J., Nochlin, D., Schellenberg, G. D., Lampe, T. H., Sadovnick, A. D., Chui, H. C., Miner, G. W., & Tinklenberg, J. R. (1989) · Annals of Neurology · doi:10.1002/ana.410250104 · Cited by 168

Familial Alzheimer's chromosome 14 mutations

Wasco, W., Pettingell, W. P., Jondro, P. D., Schmidt, S. D., Gurubhagavatula, S., Rodes, L., Di-Blasi, T., Romano, D., Guénette, S. Y., Kovacs, D. M., et al. (1995) · Nature Medicine · doi:10.1038/nm0995-848a · Cited by 109

Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques.

Fukumoto, H., Asami-Odaka, A., Suzuki, N., Shimada, H., Ihara, Y., & Iwatsubo, T. (1996) · Europe PMC (PubMed Central) · Cited by 108

Phenotype of chromosome 14–linked familial Alzheimer's disease in a large kindred

Lampe, T. H., Bird, T. D., Nochlin, D., Nemens, E. J., Risse, S. C., Sumi, S. M., Koerker, R. M., Leaird, B., Wier, M., & Raskind, M. A. (1994) · Annals of Neurology · doi:10.1002/ana.410360308 · Cited by 102

Chromosome 14–encoded Alzheimer's disease: Genetic and clinicopathological description

Haltia, M., Viitanen, M. H., Sulkava, R. O., Ala‐Hurula, V., Pöyhönen, M., Goldfarb, L. G., Brown, P., Levy, E., Houlde, H., Crook, R., et al. (1994) · Annals of Neurology · doi:10.1002/ana.410360307 · Cited by 98

Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family

Lannfelt, L., Bogdanović, N., Appelgren, H., Axelman, K., Lilius, L., Hansson, G. K., Schenk, D., Hardy, J., & Winblad, B. G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90463-4 · Cited by 89

Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 Val→Ile mutation in the amyloid precursor protein gene

MULLAN, M. J., Tsuji, S., Miki, T., Katsuya, T., Naruse, S., Kaneko, K., Shimizu, T., Kojima, T., Nakano, I., Ogihara, T., et al. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90099-w · Cited by 89

Chromosome 14 linked familial Alzheimer's disease

Kennedy, A. M., Newman, S., Frackowiak, R. S. J., Cunningham, V. J., Roques, P. K., Stevens, J., Neary, D., Bruton, C. J., Warrington, E. K., & Rossor, M. N. (1995) · Brain · doi:10.1093/brain/118.1.185 · Cited by 88

Early‐onset Alzheimer's disease in 2 large Belgian families

Martin, J. J., Gheuens, J., Bruyland, M., Cras, P. P., Vandenberghe, A., Masters, C. L., Beyreuther, K. T., Dom, R., Ceuterick, C., Lübke, U., et al. (1991) · Neurology · doi:10.1212/wnl.41.1.62 · Cited by 83

Polyclonals to β-amyloid(1–42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum

Mak, K., Yang, F., Vinters, H. V., Frautschy, S. A., & Cole, G. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91725-6 · Cited by 80

Misserise mutation of S182 gene in Italian families with early-onset Alzheimer's disease

Sorbi, S., Nacmias, B., Forleo, P., Piacentini, S., Sherrington, R. P., Rogaev, E. I., & Amaducci, L. A. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92809-x · Cited by 66

Missense mutation of S182 gene in Japanese familial Alzheimer's disease

Tanahashi, H., Mitsunaga, Y., Takahashi, K., Tasaki, H., Watanabe, S., & Tabira, T. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92810-3 · Cited by 47

Development of a monoclonal antibody specific for the COOH-terminal of beta-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders.

Murphy, G. M., Forno, L. S., Higgins, L. S., Scardina, J. M., Eng, L. F., & Cordell, B. (1994) · PubMed Central · Cited by 44

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312

Translating cell biology into therapeutic advances in Alzheimer's disease

Selkoe, D. J. (1999) · Nature · doi:10.1038/399a023 · Cited by 1,166

Amyloid, the presenilins and Alzheimer’s disease

Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

Hamley, I. W. (2012) · Chemical Reviews · doi:10.1021/cr3000994 · Cited by 892

Amyloid beta protein (A beta) deposition in chromosome 14-linked Alzheimer's disease: Predominance of A beta(42(43))

Mann, D., Iwatsubo, T., Cairns, N., Lantos, P., Nochlin, D., Sumi, S., Bird, T., Poorkaj, P., Hardy, J., Hutton, M., et al. (1996) · UCL Discovery (University College London)

Amyloid (Aβ) deposition in chromosome 1–linked Alzheimer's disease: The volga german families

Mann, D. M. A., Iwatsubo, T., Nochlin, D., Sumi, S. M., Levy‐Lahad, E., & Bird, T. D. (1997) · Annals of Neurology · doi:10.1002/ana.410410110 · Cited by 51

The PSEN1 I143T mutation in a Swedish family with Alzheimer's disease: clinical report and quantification of Aβ in different brain regions

Keller, L., Welander, H., Chiang, H., Tjernberg, L. O., Nennesmo, I., Wallin, Å. K., & Graff, C. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.107 · Cited by 40

Amyloid Angiopathy and Variability in Amyloid β Deposition Is Determined by Mutation Position in Presenilin-1-Linked Alzheimer’s Disease

Mann, D. M. A., Pickering-Brown, S. M., Takeuchi, A., & Iwatsubo, T. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64688-3 · Cited by 182

Apolipoprotein E Genotype and Deposits of Aβ40 and Aβ42 in Alzheimer Disease

McNamara, M. J., Gómez‐Isla, T., & Hyman, B. T. (1998) · Archives of Neurology · doi:10.1001/archneur.55.7.1001 · Cited by 55