The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis
Abstract
The pathogenesis of neuronal degeneration in both sporadic and familial amyotrophic lateral sclerosis (ALS) associated with mutations in superoxide dismutase may involve oxidative stress. A leading candidate as a mediator of oxidative stress is peroxynitrite, which is formed by the reaction of superoxide with nitric oxide. 3‐Nitrotyrosine is a relatively specific marker for oxidative damage mediated by peroxynitrite. In the present study, biochemical measurements showed increased concentrations of 3‐nitrotyrosine and 3‐nitro‐4‐hydroxyphenylacetic acid in the lumbar and thoracic spinal cord of ALS patients. Increased 3‐nitrotyrosine immunoreactivity was observed in motor neurons of both sporadic and familial ALS patients. Neurologic control patients with cerebral ischemia also showed increased 3‐nitrotyrosine immunoreactivity. These findings suggest that peroxynitrite‐mediated oxidative damage may play a role in the pathogenesis of both sporadic and familial ALS.
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Cites
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
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Cited by
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Oxidative stress in neurodegeneration: Cause or consequence?
Andersen, J. K. (2004) · Nature Medicine · doi:10.1038/nrn1434 · Cited by 1,869
UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS
Bruijn, L. I., Miller, T. M., & Cleveland, D. W. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144244 · Cited by 1,185
Mitochondria in neuroplasticity and neurological disorders
Mattson, M. P., Gleichmann, M., & Cheng, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.010 · Cited by 1,081
Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., Dorpe, J. V., Hellings, P., Gorselink, M., Heymans, S., et al. (2001) · Nature Genetics · doi:10.1038/88842 · Cited by 1,007
Metadata
- Authors
- Beal, M. F., Ferrante, R. J., Browne, S. E., Matthews, R. T., Kowall, N. W., & Brown, R. H.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1997-10
- Volume
- 42
- Issue
- 4
- Pages
- 644-654
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2081879241
- Cited by
- 598
- References
- 1
- FWCI
- 27.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. https://app.cochat.ai/papers/10.1002/ana.410420416
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- Beal, M. F., Ferrante, R. J., Browne, S. E., Matthews, R. T., Kowall, N. W., & Brown, R. H. (1997). Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Annals of Neurology. https://doi.org/10.1002/ana.410420416
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
