Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change
Abstract
“Drogenschmuggel”: Präpariert wurden Micellen aus Blockcopolymeren und dem Tumortherapeutikum Adriamycin (ADR), das über einen pH-sensitiven Linker an das Polymer gebunden ist (siehe Bild). Die Micellen gelangen durch Endocytose, unter Umgehung der Zellmembrantransporter, in die Krebszelle. Innerhalb der Zelle löst eine Senkung des pH-Wertes die Freisetzung von ADR aus, dessen Position fluoreszenzspektroskopisch bestimmt wird.
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In this technique, the micelles are not depolymerized, and the drug release is relatively slow.
“In this technique, the micelles are not depolymerized, and the drug release is relatively slow.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [144]
In vitro release results displayed that the micelles release ADR decreases depending on pH values from pH 7.4 to 3.0.
“In vitro release results displayed that the micelles release ADR decreases depending on pH values from pH 7.4 to 3.0.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [144]
In these delivery systems, the amphiphilic polymers are commonly stable in blood circulation and acid-sensitive bonds are hydrolyzed after cellular internalization.
“In these delivery systems, the amphiphilic polymers are commonly stable in blood circulation and acid-sensitive bonds are hydrolyzed after cellular internalization.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [144]
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- Authors
- Bae, Y., Fukushima, S., Harada, A., & Kataoka, K.
- Affiliations
- The University of Tokyo (JP)
- Corresponding author
- Kataoka, Kazunori
- Venue
- Angewandte Chemie
- Publisher
- Wiley
- Published
- 2003-10
- Volume
- 115
- Issue
- 38
- Pages
- 4788-4791
- ISSN
- 0044-8249 (ISSN-L)
- 1521-3757
- OpenAlex
- W4247118168
- Cited by
- 221
- References
- 23
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 13 · 2021: 13 · 2020: 9 · 2019: 18 · 2018: 9 · 2017: 17 · 2016: 11 · 2015: 8 · 2014: 12 · 2013: 12 · 2012: 17
- FWCI
- 3.46
- Type
- journal article
- Language
- de
- Open access
- closed
- Locations
- Angewandte Chemie (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- polymeric micelles, block copolymers, pH-responsive drug delivery, intracellular drug release, doxorubicin, pH-sensitive linker, endocytosis, cancer cells, supramolecular self-assembly
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