Metal‐Mediated Cross‐Linking in the Generation of a Marine‐Mussel Adhesive
Abstract
Iron muscles into mussels: Marine mussels adhere to rocks with a protein-based glue. An iron complex is the key curing agent in this adhesive, and the iron center is coordinated by three DOPA residues (see picture). These studies present the first identified case in which a transition-metal center is integral to forming a noncrystalline biological material.
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Coordination bonding and strong chelating bonding with transition metal compounds occur between catechol or diketone groups on the polydopamine coating layer and the interface of inorganic biosubstitutes, along with protein cross-linking.
“Such coordination bonding and strong chelating bonding with transition metal compound occur between catechol or diketone groups on the PDA coating layer and the interface of inorganic biosubstitutes along with the protein cross-linking [61–66].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [66]
Cites
Raymond, K. N., Müller, G., & Matzanke, B. F. (1984) · Topics in Current Chemistry · doi:10.1007/3-540-13099-3_2 · Cited by 357 · see citing works
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Mussel-Inspired Adhesives and Coatings
Lee, B. P., Messersmith, P. B., Israelachvili, J. N., & Waite, J. H. (2011) · Annual Review of Materials Research · doi:10.1146/annurev-matsci-062910-100429 · Cited by 1,668 · see citing works
Recent progress in synthesis and application of mussel-inspired adhesives
Guo, Q., Chen, J., Wang, J., Zeng, H., & Yu, J. (2020) · Nanoscale · doi:10.1039/c9nr09780e · Cited by 370 · see citing works
Metals and the Integrity of a Biological Coating: The Cuticle of Mussel Byssus
Holten-Andersen, N., Mates, T. E., Toprak, M. S., Stucky, G. D., Zok, F. W., & Waite, J. H. (2009) · Langmuir · doi:10.1021/la8027012 · Cited by 216 · see citing works
Design principles for creating synthetic underwater adhesives
Narayanan, A., Dhinojwala, A., & Joy, A. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00316j · Cited by 193 · see citing works
Polydopamine-Assisted Surface Modification for Bone Biosubstitutes
Huang, S., Liang, N., Hu, Y., Zhou, X., & Abidi, N. (2016) · BioMed Research International · doi:10.1155/2016/2389895 · Cited by 97 · see citing works
- Authors
- Sever, M. J., Weisser, J. T., Monahan, J., Srinivasan, S., & Wilker, J. J.
- Affiliations
- Purdue University West Lafayette (US)
- ORCID
- Wilker, Jonathan J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2004-01-14
- Volume
- 43
- Issue
- 4
- Pages
- 448-450
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2153027939
- Cited by
- 486
- References
- 1
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 19 · 2023: 16 · 2022: 28 · 2021: 26 · 2020: 29 · 2019: 33 · 2018: 27 · 2017: 23 · 2016: 24 · 2015: 30 · 2014: 39 · 2013: 21 · 2012: 29
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Ocean Engineering › Marine Biology and Environmental Chemistry
- Physical Sciences › Materials Science › Biomaterials › Calcium Carbonate Crystallization and Inhibition
- Keywords
- DOPA, iron complexes, transition metal coordination, bioadhesives, mussel foot proteins, biomimetic adhesives
- MeSH terms
- Adhesives, Animals, Cross-Linking Reagents, Dihydroxyphenylalanine, Electron Spin Resonance Spectroscopy, Ferric Compounds, Iron, Ligands, Metals, Models, Molecular, Nitrates, Oxidation-Reduction, Oxygen, Peptides, Protein Binding, Proteins, Spectrophotometry, Bivalvia
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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