The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Postsynthetic DNA Modification through the Copper‐Catalyzed Azide–Alkyne Cycloaddition Reaction
Abstract
The attachment of labels onto DNA is of utmost importance in many areas of biomedical research and is valuable in the construction of DNA‐based functional nanomaterials. The copper(I)‐catalyzed Huisgen cycloaddition of azides and alkynes (CuAAC) has recently been added to the repertoire of DNA labeling methods, thus allowing the virtually unlimited functionalization of both small synthetic oligonucleotides and large gene fragments with unprecedented efficiency. The CuAAC reaction yields the labeled polynucleotides in very high purity after a simple precipitation step. The reviewed technology is currently changing the way in which functionalized DNA strands are generated cost‐efficiently in high quality for their application in molecular diagnostics systems and nanotechnological research.
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Cites
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Oxidative Nucleobase Modifications Leading to Strand Scission
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Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition
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Click-Chemie: diverse chemische Funktionalität mit einer Handvoll guter Reaktionen
Kolb, H. C., Finn, M. G., & Sharpless, K. B. (2001) · Angewandte Chemie · doi:10.1002/1521-3757(20010601)113:11<2056::aid-ange2056>3.0.co;2-w · Cited by 1,624
Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis
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Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication
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Cited by
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
Sletten, E. M., & Bertozzi, C. R. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900942 · Cited by 3,165
Semisynthetic DNA–Protein Conjugates for Biosensing and Nanofabrication
Niemeyer, C. M. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200904930 · Cited by 369
Metadata
- Authors
- Gramlich, P. M. E., Wirges, C. T., Manetto, A., & Carell, T.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2008-10-15
- Volume
- 47
- Issue
- 44
- Pages
- 8350-8358
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2126526871
- Cited by
- 406
- References
- 48
- FWCI
- 18.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gramlich, P. M. E., Wirges, C. T., Manetto, A., & Carell, T. (2008). Postsynthetic DNA Modification through the Copper‐Catalyzed Azide–Alkyne Cycloaddition Reaction. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200802077
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
