The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Microdroplets in Microfluidics: An Evolving Platform for Discoveries in Chemistry and Biology
Open accessAbstract
Microdroplets in microfluidics offer a great number of opportunities in chemical and biological research. They provide a compartment in which species or reactions can be isolated, they are monodisperse and therefore suitable for quantitative studies, they offer the possibility to work with extremely small volumes, single cells, or single molecules, and are suitable for high‐throughput experiments. The aim of this Review is to show the importance of these features in enabling new experiments in biology and chemistry. The recent advances in device fabrication are highlighted as are the remaining technological challenges. Examples are presented to show how compartmentalization, monodispersity, single‐molecule sensitivity, and high throughput have been exploited in experiments that would have been extremely difficult outside the microfluidics platform.
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Cites
Solvent Compatibility of Poly(dimethylsiloxane)-Based Microfluidic Devices
Lee, J. N., Park, C., & Whitesides, G. M. (2003) · Analytical Chemistry · doi:10.1021/ac0346712 · Cited by 2,643
Vogelstein, B., & Kinzler, K. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9236 · Cited by 1,770
Detection and quantification of mutations in the plasma of patients with colorectal tumors
Diehl, F., Li, M., Dressman, D., He, Y., Shen, D., Szabo, S., Diaz, L. A., Goodman, S. N., David, K. A., Juhl, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507904102 · Cited by 1,188
Stochastic protein expression in individual cells at the single molecule level
Cai, L., Friedman, N., & Xie, X. S. (2006) · Nature · doi:10.1038/nature04599 · Cited by 1,145
Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents
Song, H., & Ismagilov, R. F. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0354566 · Cited by 693
Microdroplet-based PCR enrichment for large-scale targeted sequencing
Tewhey, R., Warner, J. B., Nakano, M., Libby, B., Medkova, M., David, P. H., Kotsopoulos, S. K., Samuels, M. L., Hutchison, J. B., Larson, J. W., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1583 · Cited by 454
Amplification of complex gene libraries by emulsion PCR
Williams, R., Peisajovich, S. G., Miller, O. J., Magdassi, S., Tawfik, D. S., & Griffiths, A. D. (2006) · Nature Methods · doi:10.1038/nmeth896 · Cited by 358
BEAMing up for detection and quantification of rare sequence variants
Li, M., Diehl, F., Dressman, D., Vogelstein, B., & Kinzler, K. W. (2006) · Nature Methods · doi:10.1038/nmeth850 · Cited by 261
Cited by
Seemann, R., Brinkmann, M., Pfohl, T., & Herminghaus, S. (2012) · Reports on Progress in Physics · doi:10.1088/0034-4885/75/1/016601 · Cited by 1,049
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Schneider, G. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.232 · Cited by 910
Enzymatic reactions in confined environments
Küchler, A., Yoshimoto, M., Luginbühl, S., Mavelli, F., & Walde, P. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.54 · Cited by 733
Surfactants in droplet-based microfluidics
Baret, J.-C. (2012) · Lab Chip · doi:10.1039/c1lc20582j · Cited by 649
Metadata
- Authors
- Theberge, A. B., Courtois, F., Schaerli, Y., Fischlechner, M., Abell, C., Hollfelder, F., & Huck, W. T. S.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2010-07-30
- Volume
- 49
- Issue
- 34
- Pages
- 5846-5868
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2004258912
- Cited by
- 1,059
- References
- 8
- FWCI
- 48.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Theberge, A. B., Courtois, F., Schaerli, Y., Fischlechner, M., Abell, C., Hollfelder, F., & Huck, W. T. S. (2010). Microdroplets in Microfluidics: An Evolving Platform for Discoveries in Chemistry and Biology. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200906653
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
