Cited by 2,643Microfluidic and Capillary Electrophoresis ApplicationsSilicone and Siloxane ChemistryInnovative Microfluidic and Catalytic Techniques Innovation

Solvent Compatibility of Poly(dimethylsiloxane)-Based Microfluidic Devices

Lee, Jessamine Ng, Park, Cheolmin, Whitesides, George M.·2003·Analytical Chemistry

Abstract

This paper describes the compatibility of poly(dimethylsiloxane) (PDMS) with organic solvents; this compatibility is important in considering the potential of PDMS-based microfluidic devices in a number of applications, including that of microreactors for organic reactions. We considered three aspects of compatibility: the swelling of PDMS in a solvent, the partitioning of solutes between a solvent and PDMS, and the dissolution of PDMS oligomers in a solvent. Of these three parameters that determine the compatibility of PDMS with a solvent, the swelling of PDMS had the greatest influence. Experimental measurements of swelling were correlated with the solubility parameter, delta (cal(1/2) cm(-3/2)), which is based on the cohesive energy densities, c (cal/cm(3)), of the materials. Solvents that swelled PDMS the least included water, nitromethane, dimethyl sulfoxide, ethylene glycol, perfluorotributylamine, perfluorodecalin, acetonitrile, and propylene carbonate; solvents that swelled PDMS the most were diisopropylamine, triethylamine, pentane, and xylenes. Highly swelling solvents were useful for extracting contaminants from bulk PDMS and for changing the surface properties of PDMS. The feasibility of performing organic reactions in PDMS was demonstrated by performing a Diels-Alder reaction in a microchannel.

Integrity signals

Registry

Crossref · 10.1021/ac0346712

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Specially formulated PDMS variants offer optical transparency, ease of patterning into microfluidic systems, biocompatibility, and favorable mechanics (low modulus ~145 kPa; high elasticity up to ~200% strain at break).

    “Specially formulated variants of PDMS offer physical characteristics that are attractive for this application, including optical transparency, ease of patterning into microfluidic systems, biocompatibility, and favorable mechanics (low modulus, ~145 kPa; high elasticity, up to ~200% strain at break) (35).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lee, J. N., Park, C., & Whitesides, G. M.
Affiliations
Harvard University (US)
Corresponding author
Whitesides, George M.
Venue
Analytical Chemistry
Published
2003-10-11
Volume
75
Issue
23
Pages
6544-6554
ISSN
  • 0003-2700 (ISSN-L)
  • 1520-6882
OpenAlex
W2030509793
Cited by
2,643
References
34
Citations by year
2026: 96 · 2025: 107 · 2024: 121 · 2023: 111 · 2022: 116 · 2021: 152 · 2020: 144 · 2019: 152 · 2018: 170 · 2017: 135 · 2016: 153 · 2015: 146 · 2014: 132 · 2013: 143 · 2012: 126
FWCI
29.11
Type
journal article
Language
en
Open access
closed
Locations
  • Analytical Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • Defense Advanced Research Projects Agency
  • National Institute of General Medical Sciences (GM 65364, R01GM065364)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
  • Physical Sciences › Materials Science › Materials Chemistry › Silicone and Siloxane Chemistry
  • Physical Sciences › Engineering › Biomedical Engineering › Innovative Microfluidic and Catalytic Techniques Innovation
Keywords
polydimethylsiloxane, solvent compatibility, polymer swelling, solubility parameter, cohesive energy density, microfluidics, microreactors, organic reactions, Diels-Alder reaction, microchannels, surface modification, perfluorinated solvents
MeSH terms
Dimethylpolysiloxanes, Silicones, Solvents, Microfluidics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review