Solvent Compatibility of Poly(dimethylsiloxane)-Based Microfluidic Devices
Abstract
This paper describes the compatibility of poly(dimethylsiloxane) (PDMS) with organic solvents; this compatibility is important in considering the potential of PDMS-based microfluidic devices in a number of applications, including that of microreactors for organic reactions. We considered three aspects of compatibility: the swelling of PDMS in a solvent, the partitioning of solutes between a solvent and PDMS, and the dissolution of PDMS oligomers in a solvent. Of these three parameters that determine the compatibility of PDMS with a solvent, the swelling of PDMS had the greatest influence. Experimental measurements of swelling were correlated with the solubility parameter, delta (cal(1/2) cm(-3/2)), which is based on the cohesive energy densities, c (cal/cm(3)), of the materials. Solvents that swelled PDMS the least included water, nitromethane, dimethyl sulfoxide, ethylene glycol, perfluorotributylamine, perfluorodecalin, acetonitrile, and propylene carbonate; solvents that swelled PDMS the most were diisopropylamine, triethylamine, pentane, and xylenes. Highly swelling solvents were useful for extracting contaminants from bulk PDMS and for changing the surface properties of PDMS. The feasibility of performing organic reactions in PDMS was demonstrated by performing a Diels-Alder reaction in a microchannel.
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Specially formulated PDMS variants offer optical transparency, ease of patterning into microfluidic systems, biocompatibility, and favorable mechanics (low modulus ~145 kPa; high elasticity up to ~200% strain at break).
“Specially formulated variants of PDMS offer physical characteristics that are attractive for this application, including optical transparency, ease of patterning into microfluidic systems, biocompatibility, and favorable mechanics (low modulus, ~145 kPa; high elasticity, up to ~200% strain at break) (35).”
From A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat (2016) · cites this paper as [35]
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- Authors
- Lee, J. N., Park, C., & Whitesides, G. M.
- Affiliations
- Harvard University (US)
- Corresponding author
- Whitesides, George M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-10-11
- Volume
- 75
- Issue
- 23
- Pages
- 6544-6554
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2030509793
- Cited by
- 2,643
- References
- 34
- Citations by year
- 2026: 96 · 2025: 107 · 2024: 121 · 2023: 111 · 2022: 116 · 2021: 152 · 2020: 144 · 2019: 152 · 2018: 170 · 2017: 135 · 2016: 153 · 2015: 146 · 2014: 132 · 2013: 143 · 2012: 126
- FWCI
- 29.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Defense Advanced Research Projects Agency
- National Institute of General Medical Sciences (GM 65364, R01GM065364)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Materials Science › Materials Chemistry › Silicone and Siloxane Chemistry
- Physical Sciences › Engineering › Biomedical Engineering › Innovative Microfluidic and Catalytic Techniques Innovation
- Keywords
- polydimethylsiloxane, solvent compatibility, polymer swelling, solubility parameter, cohesive energy density, microfluidics, microreactors, organic reactions, Diels-Alder reaction, microchannels, surface modification, perfluorinated solvents
- MeSH terms
- Dimethylpolysiloxanes, Silicones, Solvents, Microfluidics
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