The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
A Left‐Handed Solution to Peptide Inhibition of the p53–MDM2 Interaction
Open accessAbstract
Throwing tumors a left-hook punch: The oncoprotein MDM2 negatively regulates the activity and stability of the tumor suppressor protein p53, and is an important molecular target for anticancer therapy. Mirror-image phage display identified a high-affinity D-peptide ligand of MDM2 (see structure) that could be developed into a potent and protease-resistant p53 activator with potential antitumor activity.
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Cites
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
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How to measure and predict the molar absorption coefficient of a protein
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Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
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Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
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Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
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In situ neutralization in Boc‐chemistry solid phase peptide synthesis
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Pelay‐Gimeno, M., Glas, A., Koch, O., & Grossmann, T. N. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201412070 · Cited by 740
Modulators of Protein–Protein Interactions
Milroy, L.-G., Grossmann, T. N., Hennig, S., Brunsveld, L., & Ottmann, C. (2014) · Chemical Reviews · doi:10.1021/cr400698c · Cited by 497
Blocking of the PD‐1/PD‐L1 Interaction by a D ‐Peptide Antagonist for Cancer Immunotherapy
Chang, H., Liu, B., Qi, Y., Zhou, Y., Chen, Y., Pan, K., Li, W., Zhou, X., Ma, W., Fu, C., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506225 · Cited by 402
Liu, M., Li, C., Pazgier, M., Li, C., Mao, Y., Lv, Y., Gu, B., Wei, G., Yuan, W., Zhan, C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008930107 · Cited by 236
Self-citationYan, J., Yao, Y., Yan, S., Gao, R., Lu, W., & He, W. (2020) · Nano Letters · doi:10.1021/acs.nanolett.0c01757 · Cited by 214
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Metadata
- Authors
- Liu, M., Pazgier, M., Li, C., Yuan, W., Li, C., & Lu, W.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Lu, Wuyuan
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2010-05-06
- Volume
- 49
- Issue
- 21
- Pages
- 3649-3652
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- PMC
- PMC3359147
- OpenAlex
- W2107850581
- Cited by
- 115
- References
- 31
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 11 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 6 · 2013: 4 · 2012: 8
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI 061482, AI-072732, R01AI072732, R01AI061482)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- p53-MDM2 interaction, MDM2, p53 activation, peptide inhibitors, protease resistance, tumor suppressor, cancer therapy, protein-protein interaction inhibition
- MeSH terms
- Amino Acid Sequence, Enzyme Inhibitors, Humans, Ligands, Molecular Sequence Data, Peptides, Stereoisomerism, Drug Design, Proto-Oncogene Proteins c-mdm2
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